Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Mahdi Sarmady"'
Autor:
Lea F. Surrey, Suzanne P. MacFarland, Fengqi Chang, Kajia Cao, Komal S. Rathi, Gozde T. Akgumus, Daniel Gallo, Fumin Lin, Adam Gleason, Pichai Raman, Richard Aplenc, Rochelle Bagatell, Jane Minturn, Yael Mosse, Mariarita Santi, Sarah K. Tasian, Angela J. Waanders, Mahdi Sarmady, John M. Maris, Stephen P. Hunger, Marilyn M. Li
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-14 (2019)
Abstract Background Somatic genetic testing is rapidly becoming the standard of care in many adult and pediatric cancers. Previously, the standard approach was single-gene or focused multigene testing, but many centers have moved towards broad-based
Externí odkaz:
https://doaj.org/article/eec4d1d003314ae5aad41becf241a762
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20735 (2011)
Virus proteins alter protein pathways of the host toward the synthesis of viral particles by breaking and making edges via binding to host proteins. In this study, we developed a computational approach to predict viral sequence hotspots for binding t
Externí odkaz:
https://doaj.org/article/01a04dd9e44a467aa8bddcffc1edd4cf
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23293 (2011)
HIV proteins target host hub proteins for transient binding interactions. The presence of viral proteins in the infected cell results in out-competition of host proteins in their interaction with hub proteins, drastically affecting cell physiology. F
Externí odkaz:
https://doaj.org/article/2a97783694a8451ea6ed2b2e36588f03
Autor:
Jill R. Murrell, Addie May I. Nesbitt, Samuel W. Baker, Kieran B. Pechter, Jorune Balciuniene, Xiaonan Zhao, Elizabeth H. Denenberg, Elizabeth T. DeChene, Chao Wu, Pushkala Jayaraman, Kajia Cao, Michael Gonzalez, Marcella Devoto, Alessandro Testori, John D. Monos, Matthew C. Dulik, Laura K. Conlin, Minjie Luo, Kristin McDonald Gibson, Qiaoning Guan, Mahdi Sarmady, Elizabeth Bhoj, Ingo Helbig, Elaine H. Zackai, Emma C. Bedoukian, Alisha Wilkens, Jennifer Tarpinian, Kosuke Izumi, Cara M. Skraban, Matthew A. Deardorff, Livija Medne, Ian D. Krantz, Bryan L. Krock, Avni B. Santani
Publikováno v:
The Journal of Molecular Diagnostics. 24:274-286
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d49583b2fd1c4436346a76a80fce3d8
https://doi.org/10.1016/j.jmoldx.2021.12.002
https://doi.org/10.1016/j.jmoldx.2021.12.002
Autor:
Dimitri S. Monos, Georgios Damianos, Jamie L. Duke, Amalia Dinou, Mahdi Sarmady, Ioanna Pagkrati, Timothy Mosbruger, Eric Mbunwe, Deborah Ferriola, Anh Dinh, Ioannis Lyratzakis, Sarah A. Tishkoff, Hilary Mehler
Publikováno v:
Human immunology
The comprehensive characterization of human leukocyte antigen (HLA) genomic sequences remains a challenging problem. Despite the significant advantages of next-generation sequencing (NGS) in the field of Immunogenetics, there has yet to be a single s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9386e582cf75168fec63e07b29bf1841
https://doi.org/10.1016/j.humimm.2020.06.004
https://doi.org/10.1016/j.humimm.2020.06.004
Autor:
Nikolaos Tairis, Mahdi Sarmady, Deborah Ferriola, Timothy Mosbruger, Monica D’Arcy, Chao Wu, Xiaowu Gai, Peter M Clark, Katarzyna Mackiewicz, Pushkala Jayaraman, Dimitrios Monos, Taishan Hu
Publikováno v:
Bioinformatics
SummaryA number of methods have been devised to address the need for targeted genomic resequencing. One of these methods, Region-specific extraction (RSE) of DNA is characterized by the capture of long DNA fragments (15-20 kb) by magnetic beads, afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400371379dfafa3c7725406286232043
https://doi.org/10.1093/bioinformatics/btaa552
https://doi.org/10.1093/bioinformatics/btaa552
Autor:
Jill R, Murrell, Addie May I, Nesbitt, Samuel W, Baker, Kieran B, Pechter, Jorune, Balciuniene, Xiaonan, Zhao, Elizabeth H, Denenberg, Elizabeth T, DeChene, Chao, Wu, Pushkala, Jayaraman, Kajia, Cao, Michael, Gonzalez, Marcella, Devoto, Alessandro, Testori, John D, Monos, Matthew C, Dulik, Laura K, Conlin, Minjie, Luo, Kristin, McDonald Gibson, Qiaoning, Guan, Mahdi, Sarmady, Elizabeth, Bhoj, Ingo, Helbig, Elaine H, Zackai, Emma C, Bedoukian, Alisha, Wilkens, Jennifer, Tarpinian, Kosuke, Izumi, Cara M, Skraban, Matthew A, Deardorff, Livija, Medne, Ian D, Krantz, Bryan L, Krock, Avni B, Santani
Clinical exome sequencing (CES) aids in the diagnosis of rare genetic disorders. Herein, we report the molecular diagnostic yield and spectrum of genetic alterations contributing to disease in 700 pediatric cases analyzed at the Children's Hospital o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d01581239134e015d1fc0a4434842a48
http://hdl.handle.net/11573/1631215
http://hdl.handle.net/11573/1631215
Autor:
Adam Gleason, Mahdi Sarmady, Timothy Mosbruger, Laura K. Conlin, Georgios Damianos, Dimitrios Monos, Tristan J. Hayeck, Jonathan P. Bradfield, Jamie L. Duke, Tychele N. Turner
Balancing selection occurs when different evolutionary pressures impact the fitness of multiple alleles, resulting in increased allelic diversity in the population. A new statistical method was developed to test for selection, improving inference by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d68517d9e36dc1d363e95630fca05a64
https://doi.org/10.1101/2021.09.28.462165
https://doi.org/10.1101/2021.09.28.462165
Autor:
Emma H. Wilcox, Heidi L. Rehm, Ahmad N. Abou Tayoun, Mahdi Sarmady, Leslie G. Biesecker, Matthew Wright, Bryan Wulf
BackgroundIn silicoevidence is important to consider when interpreting genetic variants. According to the ACMG/AMP,in silicoevidence is applied at the supporting strength level using the PP3 and BP4 criteria, for pathogenic and benign evidence, respe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cfdbb54ebf824e3af9ab64ceaac2848
https://doi.org/10.1101/2021.08.09.455612
https://doi.org/10.1101/2021.08.09.455612
Autor:
Matthew S. Lebo, Ahmad N. Abou Tayoun, Chao Wu, Mahdi Sarmady, Amanda Lindy, Dianalee McKnight, Perry Evans
Publikováno v:
Genome Research. 29:1144-1151
Recent advances in DNA sequencing have expanded our understanding of the molecular basis of genetic disorders and increased the utilization of clinical genomic tests. Given the paucity of evidence to accurately classify each variant and the difficult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2c83aa18dea5b59184a3a421ae0b49
https://doi.org/10.1101/gr.240994.118
https://doi.org/10.1101/gr.240994.118