Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma

Autor: Deribe, Yonathan Lissanu, Shi, Yanxia, Rai, Kunal, Nezi, Luigi, Amin, Samir B., Wu, Chia-Chin, Akdemir, Kadir C., Mahdavi, Mozhdeh, Peng, Qian, Chang, Qing Edward, Hornigold, Kirsti, Arold, Stefan T., Welch, Heidi C. E., Garraway, Levi A., Chin, Lynda

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2016 Mar 01. 113(9), E1296-E1305.

Externí odkaz: https://www.jstor.org/stable/26468575

Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.

Autor: Lissanu Deribe Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; ylissanu@mdanderson.org lchin@mdanderson.org., Shi Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborate Center for Cancer Medicine, Guangzhou 510060, China;, Rai K; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Nezi L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Amin SB; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Wu CC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Akdemir KC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Mahdavi M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Peng Q; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Chang QE; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Hornigold K; The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom;, Arold ST; Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, 23955-6900 Saudi Arabia;, Welch HC; The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom;, Garraway LA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215; Broad Institute of MIT and Harvard, Boston, MA 02141., Chin L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, TX 77030; ylissanu@mdanderson.org lchin@mdanderson.org.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Mar 01; Vol. 113 (9), pp. E1296-305. Date of Electronic Publication: 2016 Feb 16.