Development of innovative LightSpot ® fluorescent ligands for the specific detection, localization and quantification of the Permeability-glycoprotein (P-gp), on Triple Negative Breast Cancer preclinical models

Autor: Goisnard, Antoine, Daumar, Pierre, Dubois, Clémence, Aubel, Corinne, Depresle, Marie, Roux, Manon, Penault-Llorca, Frédérique, Mounetou, Emmanuelle, Mahchid Bamdad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ed773234112d00c4c7a4e2e18b985d8

Mini-P-gp and P-gp Co-Expression in Brown Trout Erythrocytes: A Prospective Blood Biomarker of Aquatic Pollution

Autor: Emeline Valton, Christian Amblard, François Desmolles, Bruno Combourieu, Frédérique Penault-Llorca, Mahchid Bamdad

Publikováno v: Diagnostics, Vol 5, Iss 1, Pp 10-26 (2015)

In aquatic organisms, such as fish, blood is continually exposed to aquatic contaminants. Multidrug Resistance (MDR) proteins are ubiquitous detoxification membrane pumps, which recognize various xenobiotics. Moreover, their expression is induced by

Externí odkaz: https://doaj.org/article/ea64c3a645404cebb8a80fbf58f803e4

LightSpot

Autor: Antoine, Goisnard, Pierre, Daumar, Clémence, Dubois, Corinne, Aubel, Manon, Roux, Marie, Depresle, Jean, Gauthier, Bernard, Vidalinc, Frédérique, Penault-Llorca, Emmanuelle, Mounetou, Mahchid, Bamdad

Publikováno v: Cancers

Simple Summary Tumoral drug resistance is mainly caused by multidrug resistance transporters (MDR), such as the P-gp, which presents high clinical interest. For this reason, the P-gp-mediated drug resistance diagnosis may be very relevant for optimiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b391f01e0c094c97ffb49bee4191e6f1
https://pubmed.ncbi.nlm.nih.gov/34439204

LightSpot®-FL-1 fluorescent probe: a new tool for cancer drug resistance analysis by direct detection and quantification of the P-glycoprotein (MDR, ABCB1) on 2D and 3D Triple Negative Breast Cancer models

Autor: Goisnard, Antoine, Daumar, Pierre, Dubois, Clémence, Aubel, Corinne, Depresle, Marie, Roux, Manon, Gauthier, Jean, Vidalinc, Bernard, Penault-Llorca, Frédérique, Mounetou, Emmanuelle, Mahchid Bamdad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c29151cb11739e4a9fae53bb1a04d45e

Co-targeting EGFR and mTOR with gefitinib and everolimus in triple-negative breast cancer cells

Autor: Abderrahim, El Guerrab, Mahchid, Bamdad, Yves-Jean, Bignon, Frédérique, Penault-Llorca, Corinne, Aubel

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.6367. ⟨10.1038/s41598-020-63310-2⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)

International audience; Triple-negative breast cancers (TNBC) are unlikely to respond to hormonal therapies and anti-HER2-targeted therapies. TNBCs overexpress EGFR and exhibit constitutive activation of the PI3K/AKT/mTOR signalling pathway. We hypot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::53a7b953ab63dc5af0d9cfa338c35eb9
https://www.hal.inserm.fr/inserm-02750447