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Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity.

Autor: Imaide S; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.; Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka, Japan., Riching KM; Promega Corporation, Madison, WI, USA., Makukhin N; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK., Vetma V; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK., Whitworth C; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK., Hughes SJ; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.; Amphista Therapeutics Ltd., Newhouse, UK., Trainor N; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK., Mahan SD; Promega Corporation, Madison, WI, USA., Murphy N; Promega Corporation, Madison, WI, USA., Cowan AD; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK., Chan KH; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.; GlaxoSmithKline R&D, Stevenage, UK., Craigon C; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK., Testa A; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.; Amphista Therapeutics Ltd., Newhouse, UK., Maniaci C; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK.; School of Natural and Environmental Sciences, Chemistry, Newcastle University, Newcastle upon Tyne, UK., Urh M; Promega Corporation, Madison, WI, USA., Daniels DL; Promega Corporation, Madison, WI, USA. danette.daniels@promega.com., Ciulli A; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dundee, UK. a.ciulli@dundee.ac.uk.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2021 Nov; Vol. 17 (11), pp. 1157-1167. Date of Electronic Publication: 2021 Oct 21.

Targeted Protein Degradation Phenotypic Studies Using HaloTag CRISPR/Cas9 Endogenous Tagging Coupled with HaloPROTAC3.

Autor: Caine EA; Promega Corporation, Madison, Wisconsin., Mahan SD; Promega Corporation, Madison, Wisconsin., Johnson RL; Promega Corporation, Madison, Wisconsin., Nieman AN; Promega Corporation, Madison, Wisconsin., Lam N; Promega Corporation, Madison, Wisconsin., Warren CR; Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut., Riching KM; Promega Corporation, Madison, Wisconsin., Urh M; Promega Corporation, Madison, Wisconsin., Daniels DL; Promega Corporation, Madison, Wisconsin.

Publikováno v: Current protocols in pharmacology [Curr Protoc Pharmacol] 2020 Dec; Vol. 91 (1), pp. e81.

Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications.

Autor: Mishra S, Van Rechem C, Pal S, Clarke TL, Chakraborty D, Mahan SD, Black JC, Murphy SE, Lawrence MS, Daniels DL, Whetstine JR

Publikováno v: Cell [Cell] 2018 Nov 29; Vol. 175 (6), pp. 1716.