Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mahamad Yunnus A, Mahat"'
Autor:
Satyawan Jadhav, Sanjay Deshmukh, Siddharth Mhatre, Abhay Kulkarni, Shital Tondlekar, Samitabh Chakraborti, Nagarajan Muthukaman, Macchindra Tambe, Dnyandeo Pisal, Vikram Mansingh Bhosale, Neelam Sarode, Daisy Manish Shah, Mahamad Yunnus A. Mahat, Girish S. Gudi, Neelima Khairatkar-Joshi, Laxmikant Atmaram Gharat
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3766-3773
Endogenous nitrosothiols (SNOs) including S-nitrosoglutathione (GSNO) serve as reservoir for bioavailable nitric oxide (NO) and mediate NO-based signaling, inflammatory status and smooth muscle function in the lung. GSNOR inhibition increases pulmona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69f3548323ec6b3cb510c32ec44b9f3
https://doi.org/10.1016/j.bmcl.2018.10.012
https://doi.org/10.1016/j.bmcl.2018.10.012
Autor:
Satyawan Jadhav, Mahamadhanif S. Shaikh, Abhay Kulkarni, Mahamad Yunnus A. Mahat, Nagarajan Muthukaman, Srinivasa Honnegowda, Vidya Ganapati Kattige, Laxmikant Atmaram Gharat, Vikas Karande, Shital Tondlekar, Dnyandeo Pisal, Macchindra Tambe, Neelima Khairatkar-Joshi, Girish S. Gudi, Neelam Sarode, Sanjay Deshmukh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5977-5984
The discovery and SAR of potent, selective dioxane-fused tricyclic benz[ d ]imidazole derivatives as mPGES-1 inhibitor are herein described. Various amide modifications in this series afforded many potent mPGES-1 inhibitors, of which 17d proved to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74aee3215b596ce6b0bc05c3c26d7a00
https://doi.org/10.1016/j.bmcl.2016.10.079
https://doi.org/10.1016/j.bmcl.2016.10.079
Autor:
Vijayshree B. Avhad, Rajendra L. Harde, Ashwini A. Joshi, Megha Marathe, Malini Bajpai, Satyawan Jadhav, Mahamad Yunnus A. Mahat, Praveen Kumar Gupta, Sanjib Das, Neelima Khairatkar-Joshi, Maulik Nitinkumar Gandhi, Girish S. Gudi, Deepak K. Bhateja, Srinivas Gullapalli, Shelke Dnyaneshwar Eknath, A. P. Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3238-3242
We report analogue-based rational design and synthesis of two novel series of polycyclic heteroarenes, pyrrolo[3,2-b]quinolines and pyrido[2,3-b]indoles, tethered to a biaryl system by a methyl-, ethyl- or propyl ether as PDE10A inhibitors. A number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a331b93cdbdc2cec527f194f2a9492
https://doi.org/10.1016/j.bmcl.2014.06.028
https://doi.org/10.1016/j.bmcl.2014.06.028
Autor:
Nagarajan, Muthukaman, Sanjay, Deshmukh, Neelam, Sarode, Shital, Tondlekar, Macchindra, Tambe, Dnyandeo, Pisal, Mahamadhanif, Shaikh, Vidya G, Kattige, Srinivasa, Honnegowda, Vikas, Karande, Abhay, Kulkarni, Satyawan B, Jadhav, Mahamad Yunnus A, Mahat, Girish S, Gudi, Neelima, Khairatkar-Joshi, Laxmikant A, Gharat
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(24)
The discovery and SAR of potent, selective dioxane-fused tricyclic benz[d]imidazole derivatives as mPGES-1 inhibitor are herein described. Various amide modifications in this series afforded many potent mPGES-1 inhibitors, of which 17d proved to be s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd13d730eff612038af486251a9056a6
https://pubmed.ncbi.nlm.nih.gov/27865703
https://pubmed.ncbi.nlm.nih.gov/27865703
Autor:
Nagaraj M. Kulkarni, Ansar Ali Khan, J. Raghul, S. Chandrasekaran, Uma Maheswari Krishnan, Sandeep Malampati, Shridhar Narayanan, Mahamad Yunnus A. Mahat
Publikováno v:
Drug Metabolism and Personalized Therapy. 31
Background Severe forms of non-alcoholic fatty liver disease (NAFLD) adversely affect the liver physiology and hence the pharmacokinetics of drugs. Here, we investigated the effect of NAFLD on the pharmacokinetics of rosiglitazone, an insulin sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fb516c7757ea1fd2c52eb4fe1b949a
https://doi.org/10.1515/dmpt-2016-0008
https://doi.org/10.1515/dmpt-2016-0008
Autor:
Shridhar Narayanan, S. Chandrasekaran, Sridharan Rajagopal, N. Fakrudeen Ali Ahamed, Narayanan Surendran, Mahamad Yunnus A. Mahat
Publikováno v:
Journal of Neuroscience Methods. 211:272-279
A simple, reproducible and chronic technique of cerebrospinal fluid (CSF) collection in rats was developed by direct cisterna magna (CM) puncture utilizing stereotaxic apparatus. CSF collection apparatus was constructed using 1 mL syringe, silicone t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363d6b5164ae28f325d13fa9f828455d
https://doi.org/10.1016/j.jneumeth.2012.09.013
https://doi.org/10.1016/j.jneumeth.2012.09.013
Autor:
Anjana A. Adhyapak, Suraj Tubachi, Vijay Benade, Vijay Hebballi, Santosh L. Vishwakarma, Nagaraj M. Kulkarni, Saudagar Mohammad Ashfaque, B.S. Thippeswamy, Farhin R. Khan, Mahamad Yunnus A. Mahat, Basangouda M. Patil
Publikováno v:
European Journal of Pharmacology. 642:169-176
Kaempferol has been reported to inhibit nitric oxide synthase and cyclooxygenase enzymes in animal models. The present study was designed to investigate whether kaempferol modulates the cyclooxygenase pathway via inhibition of nitric oxide production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ddac9cf8cce3fe53032a9452856047
https://doi.org/10.1016/j.ejphar.2010.05.062
https://doi.org/10.1016/j.ejphar.2010.05.062
Autor:
Saranya Nidhyanandan, Farhin R. Khan, Mahamad Yunnus A. Mahat, Shilpee Chaudhary, Ramya Edunuri, B.S. Thippeswamy
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 65
Alterations in antiretroviral pharmacokinetics during pregnancy must be understood for the drugs to be used safely and effectively. Present study is an attempt to understand the potential changes in raltegravir plasma and cerebrospinal fluid pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5b13357fc48677917a31c5d303358f
https://pubmed.ncbi.nlm.nih.gov/25195836
https://pubmed.ncbi.nlm.nih.gov/25195836
Autor:
S. Chandrasekaran, P. X. Franklin, Balasubramanian Gopalan, Ansar Ali Khan, Balasubramanian Jaganatha Sivakumar, Shridhar Narayanan, K. Karthikeyan, Gajendra Singh, K. Gopal, Mahamad Yunnus A. Mahat
Publikováno v:
Biomedical Chromatography.
The present investigation describes the development and validation of a sensitive liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) method for the estimation of dorsomorphin in rat plasma. A sensitive LC-MS/MS method was developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::149afc9545340d845e02c1a769740e69
https://doi.org/10.1002/bmc.2899
https://doi.org/10.1002/bmc.2899
Autor:
K, Karthikeyan, Mahamad Yunnus A, Mahat, S, Chandrasekaran, K, Gopal, P X, Franklin, Balasubramanian Jaganatha, Sivakumar, Gajendra, Singh, Shridhar, Narayanan, B, Gopalan, Ansar A, Khan
Publikováno v:
Biomedical chromatography : BMC. 27(8)
The present investigation describes the development and validation of a sensitive liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) method for the estimation of dorsomorphin in rat plasma. A sensitive LC-MS/MS method was developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f73ffa1d8268c098f7c8d9eeffd9603b
https://pubmed.ncbi.nlm.nih.gov/23526253
https://pubmed.ncbi.nlm.nih.gov/23526253