Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mahadevabharath R. Somayaji"'
Publikováno v:
Drug Deliv Transl Res
Psoriasis and atopic dermatitis (eczema) are both common immune-mediated inflammatory skin diseases associated with changes in skin's stratum corneum lipid structure and barrier functionality. The present study aimed to investigate healthy, eczematou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c36fef544eaaeef49f977097ccc51c
https://doi.org/10.1007/s13346-021-00897-7
https://doi.org/10.1007/s13346-021-00897-7
Publikováno v:
Frontiers in Neurology, Vol 7 (2016)
Blast wave-induced traumatic brain injury (TBI) is one of the most common injuries to military personnel. Brain tissue compression/tension due to blast-induced cranial deformations and shear waves due to head rotation may generate diffuse micro-damag
Externí odkaz:
https://doaj.org/article/95916d2ecd95449795a91d5dd19cc87f
Autor:
Anna Herland, Ben Swenor, Daniel Levner, Olivier Y.F. Henry, Sasan Jalili-Firoozinezhad, Angeliki Chalkiadaki, Henry Sanchez, Andrzej Przekwas, Sauveur S. F. Jeanty, Rachelle Prantil-Baun, Josiah Sliz, Youngjae Choe, Kyung-Jin Jang, Moran Yadid, Susan Marquez, Chris Hinojosa, Thomas C. Ferrante, Blakely B. O'Connor, Tiama Hamkins-Indik, Rachel Fleming, Stephanie Dauth, Janna Nawroth, Morgan Burt, Ben M. Maoz, David B. Chou, Aaron Delahanty, John P. Ferrier, Anthony Bahinski, Jose Fernandez-Alcon, Bret Nestor, Guy Robert Thompson, Lian Leng, Robert Mannix, Michael J. Cronce, Yuka Milton, Mahadevabharath R. Somayaji, Alexandra Sontheimer-Phelps, Tae-Eun Park, Miles Ingram, Edward A. FitzGerald, Debarun Das, Ville J. Kujala, Josue A. Goss, George J. Touloumes, Toni Divic, Carlos F. Ng, Oren Levy, Zachary Tranchemontagne, Elizabeth Calamari, Geraldine A. Hamilton, Alexander Cho, Thomas Grevesse, Norman Wen, Tessa Huffstater, Donald E. Ingber, Kevin Kit Parker, Richard M. Novak
Publikováno v:
Nature Biomedical Engineering. 4:407-420
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea94accc104e59d5af0303d98dc1c94f
https://doi.org/10.1038/s41551-019-0497-x
https://doi.org/10.1038/s41551-019-0497-x
Autor:
David B. Chou, Rachelle Prantil-Baun, Ben Swenor, Sasan Jalili-Firoozinezhad, Andrzej Przekwas, Susan Marquez, Tessa Huffstater, Donald E. Ingber, Ben M. Maoz, Anna Herland, Michael J. Cronce, Yuka Milton, Angeliki Chalkiadaki, Miles Ingram, Mahadevabharath R. Somayaji, Alexandra Sontheimer-Phelps, Oren Levy, Sauveur S. F. Jeanty, Richard M. Novak, Aaron Delahanty, Kevin Kit Parker, Debarun Das
Publikováno v:
Nature Biomedical Engineering. 4:421-436
Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD modelling does not provide quantitative PK parameters. Here, we show that physiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ec82bf12b83e9e3677dba09ab7cdb54
https://doi.org/10.1038/s41551-019-0498-9
https://doi.org/10.1038/s41551-019-0498-9
Autor:
Andrzej Przekwas, Harsha T. Garimella, Carrie L. German, Debarun Das, Laurent Simon, Mahadevabharath R. Somayaji
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 167
The delivery of therapeutic drugs through the skin is a promising alternative to oral or parenteral delivery routes because dermal drug delivery systems (D3S) offer unique advantages such as controlled drug release over sustained periods and a signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591cff4605f7a2cde83f9e928dbb65c4
https://pubmed.ncbi.nlm.nih.gov/34289340
https://pubmed.ncbi.nlm.nih.gov/34289340
Autor:
Adela Ben-Yakar, David Bovard, Eva-Maria Dehne, Alessandra Dellaquila, Hendrik Erfurth, Dario Fassini, Olivier Frey, Pierre Gaudriault, Erika Györvary, Alexander P. Haring, Patrick J. Hayden, Sarah Heub, Antoni Homs-Corbera, Seiichi Ishida, Blake N. Johnson, Felix Kurth, Diane Ledroit, Seung Hwan Lee, Sasha Cai Lesher-Pérez, Frédéric Loizeau, Uwe Marx, Alexander H. McMillan, Sudip Mondal, Ann-Kristin Muhsmann, Samantha Paoletti, Andrzej Przekwas, Kasper Renggli, Vincent Revol, Antonin Sandoz, Mahadevabharath R. Somayaji, Jong Hwan Sung, Emma K. Thomée, Marine Verhulsel, Gilles Weder, J. Malcolm Wilkinson, Filippo Zanetti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44e836178e60c964d3d5efb6a934e6f9
https://doi.org/10.1016/b978-0-12-817202-5.00021-8
https://doi.org/10.1016/b978-0-12-817202-5.00021-8
The current drug discovery and development process involves costly, slow, and risk-laden preclinical in vitro and animal studies and semiempirical protocols for extrapolation of preclinical data to humans. Because of considerable differences in anato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23435dd253b720b10205621590cc0954
https://doi.org/10.1016/b978-0-12-817202-5.00011-5
https://doi.org/10.1016/b978-0-12-817202-5.00011-5
Autor:
Richard M. Novak, Rachelle Prantil-Baun, Debarun Das, Donald E. Ingber, Andrzej Przekwas, Mahadevabharath R. Somayaji
Publikováno v:
Annual Review of Pharmacology and Toxicology. 58:37-64
Physiologically based pharmacokinetic (PBPK) modeling and simulation approaches are beginning to be integrated into drug development and approval processes because they enable key pharmacokinetic (PK) parameters to be predicted from in vitro data. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b1cbcef2afc3b5928c694f66fe23d6
https://doi.org/10.1146/annurev-pharmtox-010716-104748
https://doi.org/10.1146/annurev-pharmtox-010716-104748
Publikováno v:
Drug Discovery Today. 21:1859-1862
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c40485dbb754999a781cac356d7eda
https://doi.org/10.1016/j.drudis.2016.11.002
https://doi.org/10.1016/j.drudis.2016.11.002
Autor:
Anna, Herland, Ben M, Maoz, Debarun, Das, Mahadevabharath R, Somayaji, Rachelle, Prantil-Baun, Richard, Novak, Michael, Cronce, Tessa, Huffstater, Sauveur S F, Jeanty, Miles, Ingram, Angeliki, Chalkiadaki, David, Benson Chou, Susan, Marquez, Aaron, Delahanty, Sasan, Jalili-Firoozinezhad, Yuka, Milton, Alexandra, Sontheimer-Phelps, Ben, Swenor, Oren, Levy, Kevin K, Parker, Andrzej, Przekwas, Donald E, Ingber
Publikováno v:
Nature biomedical engineering. 4(4)
Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD modelling does not provide quantitative PK parameters. Here, we show that physiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::abeca7125a56811eb81654b1270007c6
https://pubmed.ncbi.nlm.nih.gov/32042110
https://pubmed.ncbi.nlm.nih.gov/32042110