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pro vyhledávání: '"Mahad Gatti Iou"'
Autor:
Rob L. M. van Montfort, Kwai-Ming J. Cheung, L. Johnson, Mirco Meniconi, Florence I. Raynaud, P. Craig McAndrew, Rosemary Huckvale, Gavin W. Collie, Alan T. Henley, Olivier A. Pierrat, Emma Gunnell, Michael Carter, Matthew J. Rodrigues, Yann-Vaï Le Bihan, Mahad Gatti Iou, Matthew Garth Lloyd, Angela Hayes, Benjamin R. Bellenie, Rosemary Burke, Rachel Talbot, Olivia W. Rossanese, Michael D. Bright, Swen Hoelder, Owen Alexander Davis
Publikováno v:
Journal of Medicinal Chemistry
'Journal of Medicinal Chemistry ', vol: 64, pages: 17079-17097 (2021)
'Journal of Medicinal Chemistry ', vol: 64, pages: 17079-17097 (2021)
We describe the optimization of modestly active starting points to potent inhibitors of BCL6 by growing into a subpocket, which was occupied by a network of five stably bound water molecules. Identifying potent inhibitors required not only forming ne
Autor:
Stefania Criscuolo, Assunta Merolla, Mahad Gatti Iou, Fabio Benfenati, Fabrizia Cesca, Luca Maragliano
Regulation of gene transcription is an essential mechanism for differentiation and adaptation of organisms. A key actor in this regulation process is the repressor element 1 (RE1)-silencing transcription factor (REST), a transcriptional repressor tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e4d59dc2612a07cf5c741f10596aa3
https://hdl.handle.net/11368/2978309
https://hdl.handle.net/11368/2978309