Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation

Autor: Ghada H. Al-Ansary, Wagdy M. Eldehna, Hazem A. Ghabbour, Sara T. A. Al-Rashood, Khalid A. Al-Rashood, Radwa A. Eladwy, Abdullah Al-Dhfyan, Maha M. Kabil, Hatem A. Abdel-Aziz

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 986-991 (2017)

Cancer stem cells (CSCs) have been objects of intensive study since their identification in 1994. Adopting a structural rigidification approach, a novel series of 3-phenylthiazolo[3,2-a]benzimidazoles 4a–d was designed and synthesised, in an attemp

Externí odkaz: https://doaj.org/article/02f9a0e9954840abb435b4fc96bbfce4

Synthesis, X-ray crystal structure, Hirshfeld analysis and computational investigation of bis(methylthio)acrylonitrile with antimicrobial and docking evaluation

Autor: Asmaa M. Fahim, Hazem A. Ghabbour, Maha M. Kabil, Sara T. Al-Rashood, Hatem A. Abdel-Aziz

Publikováno v: Journal of Molecular Structure. 1260:132793

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d7aad72fc7c1fc32a70d9a7f3628756
https://doi.org/10.1016/j.molstruc.2022.132793

Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer

Autor: Nasser S. Al-Shakliah, Wagdy M. Eldehna, Racha Daher, Hazem A. Ghabbour, Elie Hadchity, Maiy Y. Jaballah, Hadia Almahli, Maha M. Kabil

Publikováno v: Bioorganic Chemistry. 77:443-456

Herein we report the synthesis of two series of 4-phenylphthalazin-1-ones 11a-i and 4- benzylphthalazin-1-ones 16a-h as anti-lung adenocarcinoma agents with potential inhibitory activity against PARP-1. All the newly synthesized phthalazinones were e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215cddf40087a6260732ad80080a5a75
https://doi.org/10.1016/j.bioorg.2018.01.034

Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation

Autor: Radwa A. Eladwy, Wagdy M. Eldehna, Sara T. Al-Rashood, Abdullah Al-Dhfyan, Hatem A. Abdel-Aziz, Khalid A. Al-Rashood, Hazem A. Ghabbour, Maha M. Kabil, Ghada H. Al-Ansary

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 986-991 (2017)
Journal of Enzyme Inhibition and Medicinal Chemistry

Cancer stem cells (CSCs) have been objects of intensive study since their identification in 1994. Adopting a structural rigidification approach, a novel series of 3-phenylthiazolo[3,2-a]benzimidazoles 4a–d was designed and synthesised, in an attemp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cdb82c79028ef23946bcc0088dba59
https://doaj.org/article/02f9a0e9954840abb435b4fc96bbfce4

Genotyping of Staphylococcus aureus associated with nasal colonization among healthcare workers using DNA microarray.

Autor: Senok AC; Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates. abiola.senok@mbru.ac.ae., Somily A; King Khalid University Hospital and King Saud University, Riyadh, Saudi Arabia. ali.somily@gmail.com., Raji M; Alfaisal University, Riyadh, Saudi Arabia. mraji@alfaisal.edu., Garaween G; Alfaisal University, Riyadh, Saudi Arabia. ggaraween@alfaisal.edu., Kabil M; King Saud University Medical City, Riyadh Saudi Arabia. mmqabeel@yahoo.com., Shibl A; Alfaisal University, Riyadh, Saudi Arabia. ashibl@alfaisal.edu., Monecke S; Abbott (Alere Technologies GmbH), Jena, Germany. stefan.monecke@alere.com., Ehricht R; Abbott (Alere Technologies GmbH), Jena, Germany. ralf.ehricht@alere.com.

Publikováno v: Journal of infection in developing countries [J Infect Dev Ctries] 2018 May 31; Vol. 12 (5), pp. 321-325. Date of Electronic Publication: 2018 May 31.