Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Maha Hanafi"'
Autor:
Zachary J. Waldrip, Baku Acharya, Daniel Armstrong, Maha Hanafi, Randall R. Rainwater, Sharon Amole, Madeline Fulmer, Ana Clara Azevedo-Pouly, Alaina Burns, Lyle Burdine, Brendan Frett, Marie Schluterman Burdine
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract DNA-dependent protein kinase catalytic subunit (DNA-PKcs) plays a vital role in DNA damage repair and lymphocyte function, presenting a significant target in cancer and immune diseases. Current DNA-PKcs inhibitors are undergoing Phase I/II t
Externí odkaz:
https://doaj.org/article/b870b333c6794adaa74c1377d301427d
Autor:
Joyeeta Roy, Armita Kyani, Maha Hanafi, Yibin Xu, John Takyi-Williams, Duxin Sun, Essam Eldin A. Osman, Nouri Neamati
Publikováno v:
Journal of Medicinal Chemistry. 66:1990-2019
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01fdbc921e37401f196ac01c1bcace64
https://doi.org/10.1021/acs.jmedchem.2c01769
https://doi.org/10.1021/acs.jmedchem.2c01769
Publikováno v:
J Med Chem
Napabucasin, undergoing multiple clinical trials, was reported to inhibit the signal transducer and transcription factor 3 (STAT3). To better elucidate its mechanism of action, we designed a napabucasin-based proteolysis targeting chimera (PROTAC), X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6356b912393823e4a0a595cfa58c502
https://doi.org/10.1021/acs.jmedchem.0c01897
https://doi.org/10.1021/acs.jmedchem.0c01897
Autor:
Urarika Luesakul, Dongyao Wang, Joyeeta Roy, Nouri Neamati, Dalal A. Abou El Ella, Yifeng Chai, Nongnuj Muangsin, Khaled A.M. Abouzid, Maha Hanafi, Mai I. Shahin, Deena S. Lasheen
Publikováno v:
European journal of medicinal chemistry. 155
No new and effective treatments have been approved for the treatment of esophageal squamous cell carcinoma (ESCC) in the past decade. Cisplatin and 5-fluoruracil are the most commonly used drugs for this disease. In order to develop a new class of dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10655b716c3fc6fc94c99453f02fe404
https://pubmed.ncbi.nlm.nih.gov/29908444
https://pubmed.ncbi.nlm.nih.gov/29908444