Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Maha Abdel Hakeem"'
Autor:
Rania M. Abdel Salam, Suzan M. Abuel-Maaty, Maha Abdel Hakeem, Afaf A. El-Malah, Mohga M. Badran
Publikováno v:
Medicinal Chemistry Research. 22:4087-4095
New dual binding site acetylcholinesterase (AChE) inhibitors have been designed and synthesized as a new drug candidate for the treatment of Alzheimer’s disease (AD) through the binding to both catalytic and peripheral sites of the enzyme. Therefor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8074faaefcdae92db89d0e1e7f2e180c
https://doi.org/10.1007/s00044-012-0403-5
https://doi.org/10.1007/s00044-012-0403-5
Publikováno v:
Journal of Chemical Research. 36:480-483
The synthesis and characterisation of novel tricyclic systems containing a fused thieno[3,4-d]pyrimidine nucleus starting from a useful synthon, ethyl-4-cyano-3-ethoxymethyleneamino-5-phenylamino-2-thiophenecarboxylate, are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b027a5d1171a3f9253da39b655840c74
https://doi.org/10.3184/174751912x13400242909892
https://doi.org/10.3184/174751912x13400242909892
Autor:
Afaf A. El-Malah, Maha Abdel Hakeem, Mohga M. Badran, Suzan M. Abuel-Maaty, Rania M. Abdel Salam
Publikováno v:
Archiv der Pharmazie. 343:590-601
2-Amino-3-cyanothiophenes were successfully condensed with a number of cycloalkanones to afford tacrine analogues in a one-step reaction mediated with Lewis acid. The newly synthesized compounds have been tested for their ability to inhibit acetylcho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310b71a2ee43b781bd466dafed639769
https://doi.org/10.1002/ardp.200900226
https://doi.org/10.1002/ardp.200900226
Autor:
Maha Abdel-Hakeem
Publikováno v:
Archives of Pharmacal Research. 33:813-819
Several triazenoindazoles 3a-e and triazinopyrazolopyridines 6a-i were prepared through the reaction of the corresponding 3-amino-4-chloroindazole and 3-aminopyrazolopyridine diazonium salts 2 and 5 with a number of secondary amines. All compounds we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91596fd006e94e60290d52b31731cd80
https://doi.org/10.1007/s12272-010-0603-9
https://doi.org/10.1007/s12272-010-0603-9
Publikováno v:
Journal of the Chinese Chemical Society. 53:403-412
4-(4-Acetylphenylamino)cycloocteno[4,5]thieno[2,3-d]pyrimidine (4) was prepared and condensed with certain aldehydes, phenylhydrazine, malononitrile to obtain 5a-d, 6 and 7, respectively. 4-Hydrazino & 4-substituted amino derivatives of 2-arylcyclooc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a5b15f2262fe68e7655747460254401
https://doi.org/10.1002/jccs.200600051
https://doi.org/10.1002/jccs.200600051
Publikováno v:
ChemInform. 44
A variety of new title compounds are obtained starting from the useful synthon 4-cyano-3-ethoxymethyleneamino-5-phenylamino-2-thiophenecarboxylate (I).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1d0367103440d64fcc866f871b61744
https://doi.org/10.1002/chin.201303167
https://doi.org/10.1002/chin.201303167
Autor:
Rania M. Abdel Salam, Mohga M. Badran, Suzan M. Abuel-Maaty, Afaf A. El-Malah, Maha Abdel Hakeem
Publikováno v:
ChemInform. 42
2-Amino-3-cyanothiophenes were successfully condensed with a number of cycloalkanones to afford tacrine analogues in a one-step reaction mediated with Lewis acid. The newly synthesized compounds have been tested for their ability to inhibit acetylcho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aacb8ad3e41faa817cf8a87d8ea7bc8
https://doi.org/10.1002/chin.201109169
https://doi.org/10.1002/chin.201109169
Publikováno v:
Bioorganicmedicinal chemistry. 16(1)
In an attempt to identify potential vasodilator–cardiotonic lead compounds, three series of pyridazinones were designed using three-dimensional pharmacophore developed with CATALYST software from a set of potent cyclic nucleotide phosphodiesterase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7370e8ae69db604c7be7bfd904d054d4
https://pubmed.ncbi.nlm.nih.gov/17905589
https://pubmed.ncbi.nlm.nih.gov/17905589