Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Maha A. Qadan"'
Autor:
Jelena Kornej, Maha A. Qadan, Mona Alotaibi, David R. Van Wagoner, Jeramie D. Watrous, Ludovic Trinquart, Sarah R. Preis, Darae Ko, Mohit Jain, Emelia J. Benjamin, Susan Cheng, Honghuang Lin
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Chronic inflammation is a continuous low-grade activation of the systemic immune response. Whereas downstream inflammatory markers are associated with atrial fibrillation (AF), upstream inflammatory effectors including eicosanoids are less s
Externí odkaz:
https://doaj.org/article/c95baa991f634309b1c83caa9bab448f
Autor:
Candece L. Gladson, Petra Hamerlik, Jann N. Sarkaria, Dolores Hambardzumyan, Justin D. Lathia, Steven A. Toms, Markus Bredel, Maha A. Qadan, Cameron J. Herting, Amy S. Nowacki, Adam Lauko, Manmeet S. Ahluwalia, Monica E. Burgett, Cathleen R. Carlin, Gaëlle Müller-Greven
Figure S3 shows co-localization of different fractions of bevacizumab or human IgG (hIgG) with Rab4 or LAMP1 in CD133+ GBM cells in vitro, and of rat anti-mouse VEGF-A IgG in an established tumor in the immune competent mouse model of GBM in vivo, sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d6e76ef338330b1d4f4a0e29fb4917
https://doi.org/10.1158/1078-0432.22462767
https://doi.org/10.1158/1078-0432.22462767
Autor:
Candece L. Gladson, Petra Hamerlik, Jann N. Sarkaria, Dolores Hambardzumyan, Justin D. Lathia, Steven A. Toms, Markus Bredel, Maha A. Qadan, Cameron J. Herting, Amy S. Nowacki, Adam Lauko, Manmeet S. Ahluwalia, Monica E. Burgett, Cathleen R. Carlin, Gaëlle Müller-Greven
Figure S1 shows that bevacizumab gains access to the perivascular tumor space and is internalized by tumor cells when administered to an orthotopic xenograft model of GBM and confirmation of cancer stem-like cell markers in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47804bbc80c983bc2a9d0ecc9cc07a0d
https://doi.org/10.1158/1078-0432.22462773.v1
https://doi.org/10.1158/1078-0432.22462773.v1
Autor:
Candece L. Gladson, Petra Hamerlik, Jann N. Sarkaria, Dolores Hambardzumyan, Justin D. Lathia, Steven A. Toms, Markus Bredel, Maha A. Qadan, Cameron J. Herting, Amy S. Nowacki, Adam Lauko, Manmeet S. Ahluwalia, Monica E. Burgett, Cathleen R. Carlin, Gaëlle Müller-Greven
Purpose: Bevacizumab, a humanized monoclonal antibody to VEGF, is used routinely in the treatment of patients with recurrent glioblastoma (GBM). However, very little is known regarding the effects of bevacizumab on the cells in the perivascular space
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16625d4bbc3953a5f69457664f008840
https://doi.org/10.1158/1078-0432.c.6525192
https://doi.org/10.1158/1078-0432.c.6525192
Autor:
Candece L. Gladson, Petra Hamerlik, Jann N. Sarkaria, Dolores Hambardzumyan, Justin D. Lathia, Steven A. Toms, Markus Bredel, Maha A. Qadan, Cameron J. Herting, Amy S. Nowacki, Adam Lauko, Manmeet S. Ahluwalia, Monica E. Burgett, Cathleen R. Carlin, Gaëlle Müller-Greven
Figure S7 shows bevacizumab is transcytosed across normal brain ECs and TECs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32eeb6ea3ae6e8d7e792876e12f6f703
https://doi.org/10.1158/1078-0432.22462755.v1
https://doi.org/10.1158/1078-0432.22462755.v1
Autor:
Candece L. Gladson, Petra Hamerlik, Jann N. Sarkaria, Dolores Hambardzumyan, Justin D. Lathia, Steven A. Toms, Markus Bredel, Maha A. Qadan, Cameron J. Herting, Amy S. Nowacki, Adam Lauko, Manmeet S. Ahluwalia, Monica E. Burgett, Cathleen R. Carlin, Gaëlle Müller-Greven
Figure S5 shows co-localization of a fraction of the bevacizumab-VEGF complex with Rab4 and a fraction with LAMP1 in CD133+ GBM tumor cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7d342e336c2d8806b1b9287eeb6a7f
https://doi.org/10.1158/1078-0432.22462761.v1
https://doi.org/10.1158/1078-0432.22462761.v1
Autor:
Candece L. Gladson, Petra Hamerlik, Jann N. Sarkaria, Dolores Hambardzumyan, Justin D. Lathia, Steven A. Toms, Markus Bredel, Maha A. Qadan, Cameron J. Herting, Amy S. Nowacki, Adam Lauko, Manmeet S. Ahluwalia, Monica E. Burgett, Cathleen R. Carlin, Gaëlle Müller-Greven
Figure S6 shows bevacizumab treatment causes a reduction in phospho-VEGFR2 and downregulation of VEGF-A induces autophagy in CD133+ GBM cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15340d5d25ba708fc4430854f1d0d083
https://doi.org/10.1158/1078-0432.22462758.v1
https://doi.org/10.1158/1078-0432.22462758.v1
Autor:
Candece L. Gladson, Petra Hamerlik, Jann N. Sarkaria, Dolores Hambardzumyan, Justin D. Lathia, Steven A. Toms, Markus Bredel, Maha A. Qadan, Cameron J. Herting, Amy S. Nowacki, Adam Lauko, Manmeet S. Ahluwalia, Monica E. Burgett, Cathleen R. Carlin, Gaëlle Müller-Greven
Figure S4 shows FcRn staining largely colocalizes with the endothelial cell marker vWf in xenograft GBM tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020b2cbd8032262b770dc6c538537625
https://doi.org/10.1158/1078-0432.22462764
https://doi.org/10.1158/1078-0432.22462764
Autor:
Candece L. Gladson, Petra Hamerlik, Jann N. Sarkaria, Dolores Hambardzumyan, Justin D. Lathia, Steven A. Toms, Markus Bredel, Maha A. Qadan, Cameron J. Herting, Amy S. Nowacki, Adam Lauko, Manmeet S. Ahluwalia, Monica E. Burgett, Cathleen R. Carlin, Gaëlle Müller-Greven
Figure S2 shows the internalization of bevacizumab by CD133-negative non-stem GBM tumor cells was not inhibited by EIPA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ad03864440ac4c4276060c2826dd4b
https://doi.org/10.1158/1078-0432.22462770.v1
https://doi.org/10.1158/1078-0432.22462770.v1
Autor:
Lingling Du, Manmeet Ahluwalia, Robert J. Weil, Maha A. Qadan, Amy S. Nowacki, Ruth A. Keri, Nooshin Hashemi-Sadraei, Gaelle Muller-Greven, Thomas Budd, Richard A. Prayson, Candece L. Gladson, Monica E. Burgett, Ilya V. Ulasov, Adam Lauko, Fadi W. Abdul-Karim, Jill S. Barnholtz-Sloan, Erinn Downs-Kelly, Samuel T. Chao
Publikováno v:
Journal of Neuro-Oncology. 140:237-248
Macroautophagy/autophagy is considered to play key roles in tumor cell evasion of therapy and establishment of metastases in breast cancer. High expression of LC3, a residual autophagy marker, in primary breast tumors has been associated with metasta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c30b2ff2a5173fc7f5589c1143cf005
https://doi.org/10.1007/s11060-018-2959-5
https://doi.org/10.1007/s11060-018-2959-5