Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Magnus Lundborg"'
Autor:
Mikkel Roland Holst, Maite Vidal-Quadras, Elin Larsson, Jie Song, Madlen Hubert, Jeanette Blomberg, Magnus Lundborg, Maréne Landström, Richard Lundmark
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1893-1905 (2017)
Cellular blebbing, caused by local alterations in cell-surface tension, has been shown to increase the invasiveness of cancer cells. However, the regulatory mechanisms balancing cell-surface dynamics and bleb formation remain elusive. Here, we show t
Externí odkaz:
https://doaj.org/article/2a0c27eafe414f0989737d1e9ff66866
Skin permeability prediction with MD simulation sampling spatial and alchemical reaction coordinates
Publikováno v:
Biophysical Journal. 121:3837-3849
A molecular-level understanding of skin permeation may rationalize and streamline product development, and improve quality and control, of transdermal and topical drug delivery systems. It may also facilitate toxicity and safety assessment of cosmeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df265287f0bd0842255b88e2faa8deae
https://doi.org/10.1016/j.bpj.2022.09.009
https://doi.org/10.1016/j.bpj.2022.09.009
Autor:
Mark Abraham, Andrey Alekseenko, Cathrine Bergh, Christian Blau, Eliane Briand, Mahesh Doijade, Stefan Fleischmann, Vytautas Gapsys, Gaurav Garg, Sergey Gorelov, Gilles Gouaillardet, Alan Gray, M. Eric Irrgang, Farzaneh Jalalypour, Joe Jordan, Christoph Junghans, Prashanth Kanduri, Sebastian Keller, Carsten Kutzner, Justin A. Lemkul, Magnus Lundborg, Pascal Merz, Vedran Miletić, Dmitry Morozov, Szilárd Páll, Roland Schulz, Michael Shirts, Alexey Shvetsov, Bálint Soproni, David van der Spoel, Philip Turner, Carsten Uphoff, Alessandra Villa, Sebastian Wingbermühle, Artem Zhmurov, Paul Bauer, Berk Hess, Erik Lindahl
Full documentation for the GROMACS 2023 release version.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8db8b07fe550a7e2a7fb618a97cbdd29
A molecular level understanding of skin permeation may rationalize and streamline product development, and improve quality and control, of transdermal and topical drug delivery systems. It may also facilitate toxicity and safety assessment of cosmeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ba367f3acda0996c1c4ab9e344dfaed
https://doi.org/10.1101/2022.02.10.479880
https://doi.org/10.1101/2022.02.10.479880
Publikováno v:
The Journal of investigative dermatology. 142(2)
A major role of the skin is to serve as a barrier toward the environment. The skin's permeability barrier consists of a lipid structure positioned in the stratum corneum. Recent progress in high-resolution cryo-electron microscopy (cryo-EM) has allow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0ac73b7a7fd4cc2f1f0a877b093b18
https://pubmed.ncbi.nlm.nih.gov/34474746
https://pubmed.ncbi.nlm.nih.gov/34474746
BioExcel Webinar #54: Applying the Accelerated Weight Histogram method to alchemical transformations
Autor:
Berk Hess, Magnus Lundborg
Alchemical transformations are regularly used to compute free energies of solvation, binding and mutation. The end states of interest are connected by a path using a coupling parameter lambda. The standard procedure is to run multiple simulations, ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015e2723286d7885fdfb39d6d58723ff
Autor:
Ichiro Iwai, Ali Narangifard, Lianne den Hollander, Christian L. Wennberg, HongMei Han, Bertil Daneholt, Magnus Lundborg, Lars Norlén, Erik Lindahl, Sergej Masich
Publikováno v:
The Journal of investigative dermatology. 141(5)
In vertebrates, skin upholds homeostasis by preventing body water loss. The skin's permeability barrier is located intercellularly in the stratum corneum and consists of stacked lipid lamellae composed of ceramides, cholesterol, and free fatty acids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b689d7b6e58775f8f5a4be393b4dc0c
https://pubmed.ncbi.nlm.nih.gov/33098827
https://pubmed.ncbi.nlm.nih.gov/33098827
Publikováno v:
Journal of Controlled Release. 283:269-279
Understanding and predicting permeability of compounds through skin is of interest for transdermal delivery of drugs and for toxicity predictions of chemicals. We show, using a new atomistic molecular dynamics model of the skin's barrier structure, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe5adb16e251d6e80a9cd0aa7620f33
https://doi.org/10.1016/j.jconrel.2018.05.026
https://doi.org/10.1016/j.jconrel.2018.05.026
Autor:
Ichiro Iwai, Ali Narangifard, Christian L. Wennberg, Sergej Masich, Magnus Lundborg, Erik Lindahl, Lars Norlén, Bertil Daneholt, H. Han, L. den Hollander
Publikováno v:
Experimental Cell Research. 366:139-151
The skin's permeability barrier consists of stacked lipid sheets of splayed ceramides, cholesterol and free fatty acids, positioned intercellularly in the stratum corneum. We report here on the early stage of skin barrier formation taking place insid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31dc37096819559903e674967b17bf09
https://doi.org/10.1016/j.yexcr.2018.03.010
https://doi.org/10.1016/j.yexcr.2018.03.010
Autor:
Maite Vidal-Quadras, Richard Lundmark, Jie Song, Maréne Landström, Mikkel R. Holst, Jeanette Blomberg, Madlen Hubert, Magnus Lundborg, Elin Larsson
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1893-1905 (2017)
Cellular blebbing, caused by local alterations in cell-surface tension, has been shown to increase the invasiveness of cancer cells. However, the regulatory mechanisms balancing cell-surface dynamics and bleb formation remain elusive. Here, we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a70348de9bfcf05c723aea5eea3757
https://doi.org/10.1016/j.celrep.2017.08.006
https://doi.org/10.1016/j.celrep.2017.08.006