Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells

Autor: Johan Vad-Nielsen, Nicklas Heine Staunstrup, Magnus Lindkvist Kjeldsen, Nina Dybdal, Guillaume Flandin, Claudia De Stradis, Tina Fuglsang Daugaard, Trine Vilsbøll-Larsen, Christoffer Trier Maansson, Thomas Koed Doktor, Boe Sandahl Sorensen, Anders Lade Nielsen

Publikováno v: Vad-Nielsen, J, Staunstrup, N H, Lindkvist Kjeldsen, M, Dybdal, N, Flandin, G, Stradis, C D, Daugaard, T F, Larsen, T V, Månsson, C T, Doktor, T K, Sørensen, B S & Nielsen, A L 2023, ' Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells ', Translational lung cancer research, vol. 12, no. 1 . https://doi.org/10.21037/tlcr-22-507
Vad-Nielsen, J, Staunstrup, N H, Kjeldsen, M L, Dybdal, N, Flandin, G, De Stradis, C, Daugaard, T F, Vilsbøll-Larsen, T, Maansson, C T, Doktor, T K, Sorensen, B S & Nielsen, A L 2023, ' Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells ', Translational Lung Cancer Research, vol. 12, no. 1, pp. 42-65 . https://doi.org/10.21037/tlcr-22-507

Background: Epithelial-mesenchymal-transition (EMT) is an epigenetic-based mechanism contributing to the acquired treatment resistance against receptor tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) cells harboring epidermal

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