Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Magnus Kjaergaard"'
Autor:
Janni Nielsen, Johanne Lauritsen, Jannik N. Pedersen, Jan S. Nowak, Malthe K. Bendtsen, Giulia Kleijwegt, Kaija Lusser, Laia C. Pitarch, Julián V. Moreno, Matthias M. Schneider, Georg Krainer, Louise Goksøyr, Paul Khalifé, Sanne Simone Kaalund, Susana Aznar, Magnus Kjærgaard, Vita Sereikaité, Kristian Strømgaard, Tuomas P. J. Knowles, Morten Agertoug Nielsen, Adam F. Sander, Marina Romero-Ramos, Daniel E. Otzen
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-26 (2024)
Abstract α-Synuclein (α-syn) accumulates as insoluble amyloid but also forms soluble α-syn oligomers (αSOs), thought to be even more cytotoxic than fibrils. To detect and block the unwanted activities of these αSOs, we have raised 30 monoclonal
Externí odkaz:
https://doaj.org/article/e6e9d9eb66fb4db88fab4f91ceef8060
Autor:
Freja Bohr, Søren S. -R. Bohr, Narendra Kumar Mishra, Nicolás Sebastian González-Foutel, Henrik Dahl Pinholt, Shunliang Wu, Emilie Milan Nielsen, Min Zhang, Magnus Kjaergaard, Knud J. Jensen, Nikos S. Hatzakis
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Single-molecule studies reveal the pathway organization of self-assembly and disassembly of insulin hexamers and how this is remodeled by regulatory cues and formulations. The abundance of all oligomeric species as well their kinetics are assessed.
Externí odkaz:
https://doaj.org/article/a2c4283706f740dcac2882e75c3bfc65
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Antibodies are secreted proteins that are crucial to recognition of pathogens by the immune system and are also efficient pharmaceuticals. The affinity and specificity of target recognition can increase remarkably through avidity effects, wh
Externí odkaz:
https://doaj.org/article/7b8a3aa37c394da7b6321624c51f9191
Autor:
Magnus Kjaergaard, Laura Skak Rasmussen, Johan Nygaard Vinther, Kasper Røjkjær Andersen, Ebbe Sloth Andersen, Esben Lorentzen, Søren S. Thirup, Daniel E. Otzen, Ditlev Egeskov Brodersen
Publikováno v:
Kjærgaard, M, Rasmussen, L S, Vinther, J N, Andersen, K R, Andersen, E S, Lorentzen, E, Thirup, S S, Otzen, D & Brodersen, D E 2022, ' A Semester-Long Learning Path Teaching Computational Skills via Molecular Graphics in PyMOL ', The Biophysicist, vol. 3, no. 2, pp. 106–114 . https://doi.org/10.35459/tbp.2022.000219
Structural biology describes biological processes at the molecular level and is an integral part of undergraduate study programs in molecular biosciences. Students are often fascinated by the visualizations created by molecular graphics software, whi
Publikováno v:
Dyla, M, González Foutel, N S, Otzen, D E & Kjaergaard, M 2022, ' The optimal docking strength for reversibly tethered kinases ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 25, e2203098119 . https://doi.org/10.1073/pnas.2203098119
Many kinases use reversible docking interactions to augment the specificity of their catalytic domains. Such docking interactions are often structurally independent of the catalytic domain, which allow for flexible combination of modules in evolution
Publikováno v:
Dyla, M, Kjærgaard, M, Poulsen, H & Nissen, P 2020, ' Structure and Mechanism of P-Type ATPase Ion Pumps ', Annual Review of Biochemistry, vol. 89, pp. 583-603 . https://doi.org/10.1146/annurev-biochem-010611-112801
P-type ATPases are found in all kingdoms of life and constitute a wide range of cation transporters, primarily for H+, Na+, K+, Ca2+, and transition metal ions such as Cu(I), Zn(II), and Cd(II). They have been studied through a wide range of techniqu
Autor:
Thomas C. T. Michaels, Anđela Šarić, Sara Linse, Magnus Kjaergaard, Tuomas P. J. Knowles, Alexander J. Dear, Georg Meisl
Publikováno v:
Chemical Science
Dear, A J, Meisl, G, Saric, A, Michaels, T C T, Kjaergaard, M, Linse, S & Knowles, T P J 2020, ' Identification of on-and off-pathway oligomers in amyloid fibril formation ', Chemical Science, vol. 11, no. 24, pp. 6236-6247 . https://doi.org/10.1039/c9sc06501f
Dear, A J, Meisl, G, Saric, A, Michaels, T C T, Kjaergaard, M, Linse, S & Knowles, T P J 2020, ' Identification of on-and off-pathway oligomers in amyloid fibril formation ', Chemical Science, vol. 11, no. 24, pp. 6236-6247 . https://doi.org/10.1039/c9sc06501f
A general non-binary definition for on- and off-pathway intermediates is developed, enabling comparison of amyloid oligomers' contributions to fibril formation.
The misfolding and aberrant aggregation of proteins into fibrillar structures is a k
The misfolding and aberrant aggregation of proteins into fibrillar structures is a k
Autor:
Magnus Kjaergaard
Publikováno v:
Kjaergaard, M 2022, ' Estimation of Effective Concentrations Enforced by Complex Linker Architectures from Conformational Ensembles ', Biochemistry, vol. 61, no. 3, pp. 171-182 . https://doi.org/10.1021/acs.biochem.1c00737
Proteins and protein assemblies often tether interaction partners to strengthen interactions, to regulate activity through auto-inhibition or -activation, or to boost enzyme catalysis. Tethered reactions are regulated by the architecture of the tethe
Autor:
Mateusz, Dyla, Magnus, Kjaergaard
Publikováno v:
Progress in molecular biology and translational science. 183
Protein kinase A (PKA) is regulated by a diverse class of anchoring proteins known as AKAPs that target PKA to subsets of its activators and substrates. Recently, it was reported that PKA can remain bound to its regulatory subunit after activation in
Autor:
Magnus Kjaergaard
Proteins and protein assemblies often tether interaction partners to strengthen interactions, to regulate activity through auto-inhibition or -activation, or to boost enzyme catalysis. Tethered reactions are regulated by the architecture of the tethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8917065a6cf407dc7e93d97ab5cc54d8
https://doi.org/10.1101/2021.08.13.456233
https://doi.org/10.1101/2021.08.13.456233