Výsledky vyhledávání - "Magnus J. Johansson"

Akademický článek

Late-stage meta-C–H alkylation of pharmaceuticals to modulate biological properties and expedite molecular optimisation in a single step

Autor: Lucas Guillemard, Lutz Ackermann, Magnus J. Johansson

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract Catalysed C–H activation has emerged as a transformative platform for molecular synthesis and provides new opportunities in drug discovery by late-stage functionalisation (LSF) of complex molecules. Notably, small aliphatic motifs have gai

Externí odkaz: https://doaj.org/article/708b3c8e318b499bbd388323ee8b4fa7

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Akademický článek

Late-stage synthesis of heterobifunctional molecules for PROTAC applications via ruthenium-catalysed C‒H amidation

Autor: Daniele Antermite, Stig D. Friis, Johan R. Johansson, Okky Dwichandra Putra, Lutz Ackermann, Magnus J. Johansson

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules emerging as a powerful modality in drug discovery, with the potential to address outstanding medical challenges. However, the synthetic feasibility of PROTACs, and the

Externí odkaz: https://doaj.org/article/018c82e0287d414f9caf142b4e057e8a

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Akademický článek

Electrocatalyzed direct arene alkenylations without directing groups for selective late-stage drug diversification

Autor: Zhipeng Lin, Uttam Dhawa, Xiaoyan Hou, Max Surke, Binbin Yuan, Shu-Wen Li, Yan-Cheng Liou, Magnus J. Johansson, Li-Cheng Xu, Chen-Hang Chao, Xin Hong, Lutz Ackermann

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)

Abstract Electrooxidation has emerged as an increasingly viable platform in molecular syntheses that can avoid stoichiometric chemical redox agents. Despite major progress in electrochemical C−H activations, these arene functionalizations generally

Externí odkaz: https://doaj.org/article/bdac31ddba7c44d8801256119bb301a1

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Akademický článek

Iridium-catalyzed C−H methylation and d3-methylation of benzoic acids with application to late-stage functionalizations

Autor: Erik Weis, Martin A. Hayes, Magnus J. Johansson, Belén Martín-Matute

Publikováno v: iScience, Vol 24, Iss 5, Pp 102467- (2021)

Summary: Late-stage functionalization (LSF) has over the past years emerged as a powerful approach in the drug discovery process. At its best, it allows for rapid access to new analogues from a single drug-like molecule, bypassing the need for de nov

Externí odkaz: https://doaj.org/article/c92a73b86d4b4f5c91d97ac885ddb370

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Ruthenium-catalysed C‒H amidation for the late-stage synthesis of PROTACs

Autor: Daniele Antermite, Stig D. Friis, Johan R. Johansson, Okky D. Putra, Lutz Ackermann, Magnus J. Johansson

PROteolysis TArgeting Chimeras (PROTACs) are a powerful modality in drug discovery, offering the potential to address outstanding medical challenges. However, the synthetic feasibility of PROTACs, and the empiric and complex nature of their structure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7407f4ceba551c273af6fc4bdc96808e
https://doi.org/10.26434/chemrxiv-2023-669wc

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Merging Directed C–H Activations with High-Throughput Experimentation: Development of Iridium-Catalyzed C–H Aminations Applicable to Late-Stage Functionalization

Autor: Erik Weis, Maria Johansson, Pernilla Korsgren, Belén Martín-Matute, Magnus J. Johansson

Publikováno v: JACS Au. 2:906-916

Herein, we report an iridium-catalyzed directed C-H amination methodology developed using a high-throughput experimentation (HTE)-based strategy, applicable for the needs of automated modern drug discovery. The informer library approach for investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb015812815de42db5461e2e1e713b2
https://doi.org/10.1021/jacsau.2c00039

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HTE as a Tool in C–H Activation Reaction Discovery and Late-Stage Functionalization of Pharmaceuticals

Autor: Stig D. Friis, Erik Weis, Magnus J. Johansson

Publikováno v: The Power of High-Throughput Experimentation: Case Studies from Drug Discovery, Drug Development, and Catalyst Discovery (Volume 2) ISBN: 9780841297555

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d30a0b70619e99d9a6b59580cb62d4c4
https://doi.org/10.1021/bk-2022-1420.ch010

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