Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Magnus Jäderberg"'
1
Akademický článek
ONCOS-102 plus pemetrexed and platinum chemotherapy in malignant pleural mesothelioma: a randomized phase 2 study investigating clinical outcomes and the tumor microenvironment
Autor: Magnus Jaderberg, Victor Levitsky, Luis Paz-Ares, Nicolas Isambert, Susana Cedres, Xavier Serres, Charles Ricordel, Sylvia Vetrhus, Alex Martinez-Marti, Santiago Viteri, Alejandro Navarro, Jon Zugazagoitia, Santiago Ponce, Mercedes Herrera-Juarez, Mathieu Lederlin, Thomas Birkballe Hansen
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Background ONCOS-102, an oncolytic adenovirus expressing granulocyte-macrophage colony-stimulating factor, can alter the tumor microenvironment to an immunostimulatory state. Combining ONCOS-102 with standard-of-care chemotherapy for malignant pleura
Externí odkaz: https://doaj.org/article/948af889fc44483eac5e19bcc3f77280
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5
Akademický článek
Combination of immunogenic oncolytic adenovirus ONCOS-102 with anti-PD-1 pembrolizumab exhibits synergistic antitumor effect in humanized A2058 melanoma huNOG mouse model
Autor: Lukasz Kuryk, Anne-Sophie W. Møller, Magnus Jaderberg
Publikováno v: OncoImmunology, Vol 8, Iss 2 (2019)
Malignant melanoma is an aggressive type of skin cancer whose incidence is increasing globally. Although surgery is effective in early stage melanoma, patients with advanced melanoma only have a 20% 5-year survival rate. Hence, combinations of existi
Externí odkaz: https://doaj.org/article/d1cd8bf9f2264b99bcbc7fd2d5e902dd
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6
Akademický článek
Optimization of Early Steps in Oncolytic Adenovirus ONCOS-401 Production in T-175 and HYPERFlasks
Autor: Lukasz Kuryk, Anne-Sophie W Møller, Antti Vuolanto, Sari Pesonen, Mariangela Garofalo, Vincenzo Cerullo, Magnus Jaderberg
Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 3, p 621 (2019)
Oncolytic adenoviruses can trigger lysis of tumor cells, induce an antitumor immune response, bypass classical chemotherapeutic resistance strategies of tumors, and provide opportunities for combination strategies. A major challenge is the developmen
Externí odkaz: https://doaj.org/article/bb38ce9d13224380a00610a8ac456d38
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7
Pilot Study of ONCOS-102 and Pembrolizumab: Remodeling of the Tumor Microenvironment and Clinical Outcomes in Anti–PD-1–Resistant Advanced Melanoma
Autor: Alexander N. Shoushtari, Anthony J. Olszanski, Marta Nyakas, Thomas J. Hornyak, Jedd D. Wolchok, Victor Levitsky, Lukasz Kuryk, Thomas B. Hansen, Magnus Jäderberg
Publikováno v: Clinical Cancer Research. 29:100-109
Purpose: Intratumoral oncolytic virotherapy may overcome anti–PD(L)-1 resistance by triggering pro-inflammatory remodeling of the tumor microenvironment. This pilot study investigated ONCOS-102 (oncolytic adenovirus expressing GM-CSF) plus anti–p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06be8a8edad3429d33a9dee13af7045b
https://doi.org/10.1158/1078-0432.ccr-22-2046
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