A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

Autor: Steven Bell, Andreas S. Rigas, Magnus K. Magnusson, Egil Ferkingstad, Elias Allara, Gyda Bjornsdottir, Anna Ramond, Erik Sørensen, Gisli H. Halldorsson, Dirk S. Paul, Kristoffer S. Burgdorf, Hannes P. Eggertsson, Joanna M. M. Howson, Lise W. Thørner, Snaedis Kristmundsdottir, William J. Astle, Christian Erikstrup, Jon K. Sigurdsson, Dragana Vuckovic, Khoa M. Dinh, Vinicius Tragante, Praveen Surendran, Ole B. Pedersen, Brynjar Vidarsson, Tao Jiang, Helene M. Paarup, Pall T. Onundarson, Parsa Akbari, Kaspar R. Nielsen, Sigrun H. Lund, Kristinn Juliusson, Magnus I. Magnusson, Michael L. Frigge, Asmundur Oddsson, Isleifur Olafsson, Stephen Kaptoge, Henrik Hjalgrim, Gudmundur Runarsson, Angela M. Wood, Ingileif Jonsdottir, Thomas F. Hansen, Olof Sigurdardottir, Hreinn Stefansson, David Rye, DBDS Genomic Consortium, James E. Peters, David Westergaard, Hilma Holm, Nicole Soranzo, Karina Banasik, Gudmar Thorleifsson, Willem H. Ouwehand, Unnur Thorsteinsdottir, David J. Roberts, Patrick Sulem, Adam S. Butterworth, Daniel F. Gudbjartsson, John Danesh, Søren Brunak, Emanuele Di Angelantonio, Henrik Ullum, Kari Stefansson

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)

Bell et al. report 46 new loci associated with biomarkers of iron homeostasis, including ferritin levels, iron binding capacity, and iron saturation, in the Icelandic, Danish and UK populations. The associated loci point to new iron-regulating protei

Externí odkaz: https://doaj.org/article/35ea0870b7404ce2af991707d7676fe3

The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large‐Scale Proteomics Scan in Iceland

Autor: Hilma Holm, Kristbjorg Gunnarsdottir, Michael L. Frigge, Gudmundur Thorgeirsson, Erna V. Ivarsdottir, Thorunn Rafnar, Saedis Saevarsdottir, Helgi Jonsson, Unnur Thorsteinsdottir, Gudmundur L. Norddahl, Sigrun H. Lund, Gyda Bjornsdottir, Kari Stefansson, Daniel F. Gudbjartsson, Patrick Sulem, Magnus I. Magnusson, I. Jonsdottir, Thorvaldur Ingvarsson, Unnur Styrkarsdottir

Publikováno v: Arthritis & Rheumatology (Hoboken, N.j.)

Objective Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement. Methods Using th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ff88fe8b35459f59a2cf5112d7992d
https://doi.org/10.1002/art.41793

A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

Autor: Christian Erikstrup, Jon K. Sigurdsson, Dragana Vuckovic, Isleifur Olafsson, Daniel F. Gudbjartsson, Vinicius Tragante, Steven Bell, Stephen Kaptoge, Andreas S. Rigas, Snaedis Kristmundsdottir, Khoa Manh Dinh, Hreinn Stefansson, Helene M. Paarup, Anna Ramond, Kristinn Juliusson, Hannes P. Eggertsson, Pall T. Onundarson, Erik Sørensen, Gudmundur Runarsson, Parsa Akbari, Tao Jiang, Søren Brunak, David J. Roberts, Willem H. Ouwehand, Asmundur Oddsson, Gisli H. Halldorsson, Adam S. Butterworth, James E Peters, Brynjar Vidarsson, Hilma Holm, Magnus I Magnusson, Kari Stefansson, Joanna M. M. Howson, Lise Wegner Thørner, Angela M. Wood, Karina Banasik, Sigrun H. Lund, Henrik Hjalgrim, Olof Sigurdardottir, David Westergaard, Emanuele Di Angelantonio, Unnur Thorsteinsdottir, Henrik Ullum, John Danesh, Gudmar Thorleifsson, Egil Ferkingstad, Michael L. Frigge, Patrick Sulem, Ingileif Jonsdottir, Thomas Hansen, Ole Birger Pedersen, Magnus K. Magnusson, David B. Rye, Dirk S. Paul, Gyda Bjornsdottir, Praveen Surendran, Elias Allara, William J. Astle, Kaspar René Nielsen, Nicole Soranzo, Kristoffer Sølvsten Burgdorf

Publikováno v: Bell, S, Rigas, A S, Magnusson, M K, Ferkingstad, E, Allara, E, Bjornsdottir, G, Ramond, A, Sørensen, E, Halldorsson, G H, Paul, D S, Burgdorf, K S, Eggertsson, H P, Howson, J M M, Thørner, L W, Kristmundsdottir, S, Astle, W J, Erikstrup, C, Sigurdsson, J K, Vuckovic, D, Dinh, K M, Tragante, V, Surendran, P, Pedersen, O B, Vidarsson, B, Jiang, T, Paarup, H M, Onundarson, P T, Akbari, P, Nielsen, K R, Lund, S H, Juliusson, K, Magnusson, M I, Frigge, M L, Oddsson, A, Olafsson, I, Kaptoge, S, Hjalgrim, H, Runarsson, G, Wood, A M, Jonsdottir, I, Hansen, T F, Sigurdardottir, O, Stefansson, H & DBDS Genomic Consortium 2021, ' A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis ', Communications Biology, vol. 4, no. 1, 156 . https://doi.org/10.1038/s42003-020-01575-z
Communications Biology
Bell, S, Rigas, A S, Magnusson, M K, Ferkingstad, E, Allara, E, Bjornsdottir, G, Ramond, A, Sørensen, E, Halldorsson, G H, Paul, D S, Burgdorf, K S, Eggertsson, H P, Howson, J M M, Thørner, L W, Kristmundsdottir, S, Astle, W J, Erikstrup, C, Sigurdsson, J K, Vuckovic, D, Dinh, K M, Tragante, V, Surendran, P, Pedersen, O B, Vidarsson, B, Jiang, T, Paarup, H M, Onundarson, P T, Akbari, P, Nielsen, K R, Lund, S H, Juliusson, K, Magnusson, M I, Frigge, M L, Oddsson, A, Olafsson, I, Kaptoge, S, Hjalgrim, H, Runarsson, G, Wood, A M, Hansen, T F, Burgdorf, K S, Jemec, G, Jennum, P, Nielsen, K R, Petersen, M, Werge, T, Westergaard, D, Banasik, K, Brunak, S, Ullum, H & DBDS Genomic Consortium 2021, ' A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis ', Communications Biology, vol. 4, no. 1, 156 . https://doi.org/10.1038/s42003-020-01575-z
DBDS Genomic Consortium, Westergaard, D, Banasik, K, Brunak, S & Ullum, H 2021, ' A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis ', Communications Biology, vol. 4, no. 1, 156, pp. 156 . https://doi.org/10.1038/s42003-020-01575-z
Bell, S, Rigas, A S, Magnusson, M K, Ferkingstad, E, Allara, E, Bjornsdottir, G, Ramond, A, Sørensen, E, Halldorsson, G H, Paul, D S, Burgdorf, K S, Eggertsson, H P, Howson, J M M, Thørner, L W, Kristmundsdottir, S, Astle, W J, Erikstrup, C, Sigurdsson, J K, Vuckovic, D, Dinh, K M, Tragante, V, Surendran, P, Pedersen, O B, Vidarsson, B, Jiang, T, Paarup, H M, Onundarson, P T, Akbari, P, Nielsen, K R, Lund, S H, Juliusson, K, Magnusson, M I, Frigge, M L, Oddsson, A, Olafsson, I, Kaptoge, S, Hjalgrim, H, Runarsson, G, Wood, A M, Jonsdottir, I, Hansen, T F, Sigurdardottir, O, Stefansson, H, Rye, D, DBDS Genomic Consortium, Peters, J E, Westergaard, D, Holm, H, Soranzo, N, Banasik, K, Thorleifsson, G, Ouwehand, W H, Thorsteinsdottir, U, Roberts, D J, Sulem, P, Butterworth, A S, Gudbjartsson, D F, Danesh, J, Brunak, S, Di Angelantonio, E, Ullum, H, Stefansson, K & Nyegaard, M 2021, ' A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis ', Communications Biology, vol. 4, no. 1, 156 . https://doi.org/10.1038/s42003-020-01575-z
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
communications biology

Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of blood levels of ferritin (N = 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48454db0daf08828ff58ba5c38fa6a78
https://pure.au.dk/portal/da/publications/a-genomewide-metaanalysis-yields-46-new-loci-associating-with-biomarkers-of-iron-homeostasis(f74a643b-7d4c-4ddc-af3c-42fcad09ef09).html

Automated brainstem parcellation using multi-atlas segmentation and deep neural network

Autor: Lotta Maria Ellingsen, Askell Love, Magnus I. Magnusson

About 5-8% of individuals over the age of 60 have dementia. With our ever-aging population this number is likely to increase, making dementia one of the most important threats to public health in the 21st century. Given the phenotypic overlap of indi

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http://arxiv.org/abs/2102.03281