Identification of FAM173B as a protein methyltransferase promoting chronic pain.

Autor: Hanneke L D M Willemen, Annemieke Kavelaars, Judith Prado, Mirjam Maas, Sabine Versteeg, Lara J J Nellissen, Jeshua Tromp, Rafael Gonzalez Cano, Wenjun Zhou, Magnus E Jakobsson, Jędrzej Małecki, George Posthuma, Abdella M Habib, Cobi J Heijnen, Pål Ø Falnes, Niels Eijkelkamp

Publikováno v: PLoS Biology, Vol 16, Iss 2, p e2003452 (2018)

Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic widespread pain. This region incl

Externí odkaz: https://doaj.org/article/66efd9c0e1c7495d85239fbfe2edd509

Hsp70 (HSPA1) Lysine Methylation Status as a Potential Prognostic Factor in Metastatic High-Grade Serous Carcinoma.

Autor: Magnus E Jakobsson, Anders Moen, Ben Davidson, Pål Ø Falnes

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0140168 (2015)

Cellular proteins are subject to frequent methylation on lysine residues, introduced by specific methyltransferases, and each lysine residue can receive up to three methyl groups. Histone methylations, which are key determinants of chromatin state an

Externí odkaz: https://doaj.org/article/e2d63c4c677e4d8c9b866b87f24ded6a

Structure, Activity and Function of the Dual Protein Lysine and Protein N-Terminal Methyltransferase METTL13

Autor: Magnus E. Jakobsson

Publikováno v: Life, Vol 11, Iss 11, p 1121 (2021)

METTL13 (also known as eEF1A-KNMT and FEAT) is a dual methyltransferase reported to target the N-terminus and Lys55 in the eukaryotic translation elongation factor 1 alpha (eEF1A). METTL13-mediated methylation of eEF1A has functional consequences rel

Externí odkaz: https://doaj.org/article/fa746b5af7c747a58f040cfdbcd85a7e

Analyses of plasma inflammatory proteins reveal biomarkers predictive of subsequent development of giant cell arteritis: a prospective study

Autor: Karin Wadström, Lennart T H Jacobsson, Aladdin J Mohammad, Kenneth J Warrington, Eric L Matteson, Magnus E Jakobsson, Carl Turesson

Publikováno v: Rheumatology.

ObjectiveTo investigate the relation between biomarkers of inflammation and subsequent development of GCA.MethodParticipants in the population-based Malmö Diet Cancer Study (MDCS; N = 30 447), established 1991–96, who were subsequently diagnosed w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2215063833a111d2b245b201012d084
https://doi.org/10.1093/rheumatology/keac581

FRMD6 has tumor suppressor functions in prostate cancer

Autor: Jakob Haldrup, Magnus E. Jakobsson, Benedicte Parm Ulhøi, Stine Hedensted, Martin K. Thomsen, Siri H. Strand, Zsofia Kote-Jarai, Maria Riedel, Clara Cieza-Borrella, Jesper V. Olsen, Karina Dalsgaard Sørensen, Rosalind A. Eeles, Michael Borre, Maibritt Nørgaard, Frederik Dagnæs-Hansen

Publikováno v: Haldrup, J, Strand, S H, Cieza-Borrella, C, Jakobsson, M E, Riedel, M, Norgaard, M, Hedensted, S, Dagnaes-Hansen, F, Ulhoi, B P, Eeles, R, Borre, M, Olsen, J V, Thomsen, M, Kote-Jarai, Z & Sorensen, K D 2021, ' FRMD6 has tumor suppressor functions in prostate cancer ', Oncogene, vol. 40, no. 4, pp. 763–776 . https://doi.org/10.1038/s41388-020-01548-w
Haldrup, J, Strand, S H, Cieza-Borrella, C, Jakobsson, M E, Riedel, M, Norgaard, M, Hedensted, S, Dagnaes-Hansen, F, Ulhoi, B P, Eeles, R, Borre, M, Olsen, J, Thomsen, M, Kote-Jarai, Z & Sorensen, K D 2021, ' FRMD6 has tumor suppressor functions in prostate cancer ', Oncogene, vol. 40, pp. 763-776 . https://doi.org/10.1038/s41388-020-01548-w

Available tools for prostate cancer (PC) prognosis are suboptimal but may be improved by better knowledge about genes driving tumor aggressiveness. Here, we identified FRMD6 (FERM domain-containing protein 6) as an aberrantly hypermethylated and sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914cfdc1c90019ae6afe3568ddef6eed
https://doi.org/10.1038/s41388-020-01548-w