Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Magnus C. Eriksson"'
Autor:
Guisheng Li, Zhulin Tan, Yibo Xu, Kanwar P. S. Sidhu, Bo Qu, Melissa A. Herbage, Magnus C. Eriksson, Xingzhong Zeng, Carl A. Busacca, Jean-Nicolas Desrosiers, Thomas Hampel, Oliver Niemeier, Carsten Reichel, Mai Thi Quynh Dang, Marvin Schoerer, Dirk Kemmer, Melanie Eick, Holger Werle, Soojin Kim, Zhibin Li, Shankar Venkatraman, Lanqi Jia, David A. Claremon, Klaus Fuchs, Niklas Heine, Denis Byrne, Bikshandarkoil Narayanan, Max Sarvestani, Joe Johnson, Ajith Premasiri, Larry J. Nummy, Jon C. Lorenz, Nizar Haddad, Nina C. Gonnella, Scott Pennino, Mariusz Krawiec, Chris H. Senanayake, Frederic Buono, Heewon Lee, Azad Hossain, Jinhua J. Song, Jonathan T. Reeves
Publikováno v:
Organic Process Research & Development. 26:3345-3372
Autor:
Chris H. Senanayake, Carl A. Busacca, Diana C. Reeves, Jinghua Xu, Xingzhong Zeng, Vittorio Farina, Magnus C. Eriksson
Publikováno v:
Synlett. 29:1455-1460
DBU as base is key in a practical modified Guareschi–Thorpe cyclization of β-keto esters and 2-cyanoacetamide to allow the synthesis of substituted pyridones in good to excellent yields. The chlorination of DBU salts of pyridones with POCl3 in the
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:300-304
3-Amino-4-(1,1-difluoro-propyl)-6-(4-methanesulfonyl-piperidin-1-yl)-thieno[2,3-b]pyridine-2-carboxylic acid amide (1) is a potent IκB Kinase-β (IKK-β) inhibitor. The efficient preparations of this compound labeled with carbon-14 and deuterium are
Autor:
Magnus C. Eriksson, Marjorie Egan, Gerald A. Wächter, Margaret M. Faul, Zhihong Ge, Ingrid Mergelsberg, Mark D. Argentine, John D. Orr, Fred Hicks, William F. Kiesman, Maciej Smulkowski
Publikováno v:
Organic Process Research & Development. 19:915-924
Designation and justification of an Active Pharmaceutical Ingredient Starting Material (API SM) is an important aspect of the drug development and commercialization process and defines the point at which the GMP manufacturing process starts (ICH Q7:
Autor:
Nathan K. Yee, Suresh R. Kapadia, Heewon Lee, Laurence J. Nummy, Carl A. Busacca, Chris H. Senanayake, Frederic G. Buono, Bing-Shiou Yang, Magnus C. Eriksson, Jason Brazzillo, Jon C. Lorenz
Publikováno v:
Organic Process Research & Development. 18:1527-1534
A convenient and high-yielding method for the synthesis of trans-(dioxo)-azabicyclo-[3.1.0]-hexane carboxylate, a key intermediate of complex molecules, is presented using a flow cyclopropanation process. From a detailed kinetic study, it is demonstr
Autor:
Margaret M. Faul, Fred Hicks, William F. Kiesman, Maciej Smulkowski, John D. Orr, Carl A. Busacca, Steven Pfeiffer, Magnus C. Eriksson
Publikováno v:
Organic Process Research & Development. 18:594-600
Designation and justification of active pharmaceutical ingredient starting material (API SM) is a standard part of the drug development and commercialization process. However, knowledge of current practices used within the industry varies, depending
Autor:
Steven Pfeiffer, John D. Orr, Maciej Smulkowski, Carl A. Busacca, Fred Hicks, William F. Kiesman, Margaret M. Faul, Magnus C. Eriksson
Publikováno v:
Organic Process Research & Development. 18:587-593
Designation and justification of active pharmaceutical ingredient starting material (API SM) is a standard part of the drug substance (DS) development and commercialization process. However, current industry practices are not well understood and vary
Autor:
Bo Qu, Jason A. Mulder, Max Sarvestani, Rogelio P. Frutos, Nizar Haddad, Jinhua J. Song, Tampone Thomas G, Magnus C. Eriksson, Nitinchandra D. Patel, Sherry Shen, Xiufeng Sun, Joe Gao, Chris H. Senanayake
Publikováno v:
Organic Process Research & Development. 17:940-945
Reported herein is a safe and economical synthesis of methyl 6-chloro-5-(trifluoromethyl)nicotinate, an intermediate in the synthesis of novel anti-infective agents. The key to this process is the trifluoromethylation of an aryl iodide using an inexp
Autor:
Dajun Chen, Bo Qu, Bruce Z. Lu, Carl A. Busacca, Keith R. Fandrick, Nicole Grět, Anjan Saha, Yaping Hong, Zhibin Li, Nizar Haddad, Diana C. Reeves, Shengli Ma, Jiang Ping Wu, Chris H. Senanayake, Magnus C. Eriksson, Heewon Lee, Nelu Grinberg, Maurice A. Marsini
Publikováno v:
Advanced Synthesis & Catalysis. 355:1455-1463
The modular nature of the BIPI ligands allows for systematic optimization of each ligand region. The development of ligands optimized for asymmetric hydrogenation of the challenging unfunctionalized olefin substrate class is described. The naphthyl p
Autor:
Michael Spinelli, Jiang-Ping Wu, Austin Gold, Anjan Saha, Chris H. Senanayake, Zhibin Li, Carl A. Busacca, Nizar Haddad, Elisa Farber, Bo Qu, Nicole Grět, Shengli Ma, Nelu Grinberg, Heewon Lee, Magnus C. Eriksson, Steve Han, Peter Wipf, Guijun Wang, Keith R. Fandrick
Publikováno v:
Organic Letters. 15:1132-1135
The first uncatalyzed hydrophosphinations of propargylic amines and alcohols with phosphine- borane complexes are described. The reactions proceed at ambient temperature or below without the use of protecting groups or the need to handle pyrophoric s