Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Magnus Ronn"'
Autor:
Wu-Yan Zhang, Minsheng He, Chi-Li Chen, Zhijian Zhu, Philip John Hogan, Nicholas Dunwoody, Magnus Ronn, Olga Gilicky
Publikováno v:
Organic Process Research & Development. 21:377-386
Process research, development, and manufacture of TP-808 (1), a key intermediate for the discovery and manufacture of tetracycline analogues, is described. The process used for the preparation of 1 avoids chromatographic purifications and has been su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47609db48039900f2c880bd3b121566e
https://doi.org/10.1021/acs.oprd.7b00003
https://doi.org/10.1021/acs.oprd.7b00003
Autor:
John Niu, Yonghong Deng, Magnus Ronn, Zhijian Zhu, Philip C. Hogan, Chi-Li Chen, Diana K. Hunt, Minsheng He, Wu-Yan Zhang, Xiao-Yi Xiao, Cuixiang Sun, Christopher E. Katz, Nicholas Dunwoody
Publikováno v:
Organic Process Research & Development. 20:284-296
Process research and development of the fully synthetic broad spectrum tetracycline TP-2758, with a chiral pyrrolidine side chain at the C-8 position, is described. The process utilizes two key intermediates, 7 and 10, in a convergent approach that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::757978d468e88e7bf9bb08c427f0b222
https://doi.org/10.1021/acs.oprd.5b00404
https://doi.org/10.1021/acs.oprd.5b00404
Autor:
Philip C. Hogan, Olga Gilicky, Zhimin Wang, Magnus Ronn, Danny Lafrance, Chi-Li Chen, John Niu, Wu-Yan Zhang, Nicholas Dunwoody
Publikováno v:
Organic Process Research & Development. 19:1784-1795
A robust, cost-effective, and high yielding manufacturing process for enantiomerically enriched (S)-allylic amine 3, a key intermediate for fully synthetic tetracyclines have been developed. Two novel and scalable asymmetric vinylations resulting in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09646552ec175274a3463920d90aac93
https://doi.org/10.1021/acs.oprd.5b00274
https://doi.org/10.1021/acs.oprd.5b00274
Autor:
Trudy H. Grossman, Minsheng He, Chi-Li Chen, Joyce A. Sutcliffe, Corey Fyfe, Wu-Yan Zhang, Zhijian Zhu, Magnus Ronn, Diana K. Hunt, Yonghong Deng, Xiao-Yi Xiao, John Niu, Christopher E. Katz, Cuixiang Sun, Catherine Achorn, William J. O’Brien, Philip C. Hogan, Roger B. Clark
Publikováno v:
Journal of Medicinal Chemistry. 56:8112-8138
The C-8 position of the tetracyclines has been largely underexplored because of limitations in traditional semisynthetic techniques. Employing a total synthetic approach allowed for modifications at the C-7 and C-8 positions, enabling the generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5772e692d3ba05ed3fa43ae2aaeb375f
https://doi.org/10.1021/jm401211t
https://doi.org/10.1021/jm401211t
Autor:
Wu-Yan Zhang, Zhijian Zhu, Philip C. Hogan, Magnus Ronn, Chi-Li Chen, John Niu, Yonghong Deng, Christopher E. Katz, Roger B. Clark, Xiao-Yi Xiao, Diana K. Hunt, Cuixiang Sun, Minsheng He, Olga Gilicky, Nicholas Dunwoody
Publikováno v:
Organic Process Research & Development. 17:838-845
Process research and development of the first fully synthetic broad spectrum 7-fluorotetracycline in clinical development is described. The process utilizes two key intermediates in a convergent approach. The key transformation is a Michael–Dieckma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8adac5b66737a518fc9a0ca8b62dbae8
https://doi.org/10.1021/op4000219
https://doi.org/10.1021/op4000219
Autor:
William J. O’Brien, Cuixiang Sun, Joyce A. Sutcliffe, Corey Fyfe, Jingye Zhou, Xiao-Yi Xiao, Roger B. Clark, Wu-Yan Zhang, Trudy H. Grossman, Magnus Ronn, Louis Plamondon, Nick Dunwoody, Diana K. Hunt
Publikováno v:
Journal of Medicinal Chemistry. 55:597-605
This and the accompanying report (DOI: 10.1021/jm201467r ) describe the design, synthesis, and evaluation of a new generation of tetracycline antibacterial agents, 7-fluoro-9-substituted-6-demethyl-6-deoxytetracyclines ("fluorocyclines"), accessible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ca3e23f7dce519d309a723bf943eaa
https://doi.org/10.1021/jm201465w
https://doi.org/10.1021/jm201465w
Autor:
Louis Plamondon, Magnus Ronn, Quentin J. Mccubbin, Neil Grimster, Tony Alorati, Melanie K. Veige, Steve Winter
Publikováno v:
Organic Process Research & Development. 11:241-245
An expedient synthesis of MLN1251 has been developed that allows for the production of multikilogram quantities of the target compound. The key transformation is synthesis of a 5-hydroxyindole by a Nenitzescu reaction. The longest linear sequence is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70acdb0e2dc213346a476a60fce25f0a
https://doi.org/10.1021/op060245h
https://doi.org/10.1021/op060245h
Publikováno v:
Synlett. 2012:134-136
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d512c5088aea18b3dfc241a1d440a49e
https://doi.org/10.1055/s-0031-1290103
https://doi.org/10.1055/s-0031-1290103
Autor:
Louis Plamondon, Diana K. Hunt, Magnus Ronn, Catherine Achorn, Xiao-Yi Xiao, Zhijian Zhu, Philip C. Hogan, Chi-Li Chen, Trudy H. Grossman, Minsheng He, Roger B. Clark, William J. O’Brien, Yonghong Deng, Joyce A. Sutcliffe, Corey Fyfe
Publikováno v:
Journal of medicinal chemistry. 55(2)
Utilizing a fully synthetic route to tetracycline analogues, the C-9 side-chain of the fluorocyclines was optimized for both antibacterial activity and oral efficacy. Compounds were identified that overcome both efflux (tet(K), tet(A)) and ribosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dade266c1683e7d67b934468a5a8330
https://pubmed.ncbi.nlm.nih.gov/22148555
https://pubmed.ncbi.nlm.nih.gov/22148555
Autor:
Wu-Yan Zhang, Philip C. Hogan, Chi-Li Chen, John Niu, Zhimin Wang, Danny Lafrance, Olga Gilicky, Nicholas Dunwoody, Magnus Ronn
Publikováno v:
Organic Process Research & Development; Nov2015, Vol. 19 Issue 11, p1784-1795, 12p