Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Magnus, Schou"'
Autor:
Simon Ekman, Zsolt Cselényi, Andrea Varrone, Aurelija Jucaite, Heather Martin, Magnus Schou, Peter Johnström, Gianluca Laus, Rolf Lewensohn, Andrew P. Brown, Jasper van derAart, Karthick Vishwanathan, Lars Farde
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 6, Pp 955-965 (2023)
Abstract Brain metastases (BMs) are associated with poor prognosis in epidermal growth factor receptor mutation‐positive (EGFRm) non‐small cell lung cancer (NSCLC). Osimertinib is a third‐generation, irreversible, EGFR‐tyrosine kinase inhibit
Externí odkaz:
https://doaj.org/article/fe8e055f9652498db9a233ac1fdc48e7
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 955 (2023)
The Pd–Xantphos-mediated 11C-carbonylation protocol (also known as the “Xantphos- method”), due to its simplistic and convenient nature, has facilitated researchers in meeting a longstanding need for preparing 11C-carbonyl-labeled radiopharmace
Externí odkaz:
https://doaj.org/article/c6f40108abc94f30b22d10e027a5f0a6
Autor:
Zsolt Cselényi, Aurelija Jucaite, Cecilia Kristensson, Per Stenkrona, Pär Ewing, Andrea Varrone, Peter Johnström, Magnus Schou, Ana Vazquez-Romero, Mohammad Mahdi Moein, Martin Bolin, Jonathan Siikanen, Pär Grybäck, Bengt Larsson, Christer Halldin, Ken Grime, Ulf G. Eriksson, Lars Farde
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Background The radioligand [11C]VC-002 was introduced in a small initial study long ago for imaging of muscarinic acetylcholine receptors (mAChRs) in human lungs using positron emission tomography (PET). The objectives of the present study i
Externí odkaz:
https://doaj.org/article/b57a1b395ada441a9bd3f59c5762420f
Autor:
Anton Lindberg, Ryosuke Arakawa, Tsuyoshi Nogami, Sangram Nag, Magnus Schou, Charles S. Elmore, Lars Farde, Victor W. Pike, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-8 (2019)
Abstract Background Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist li
Externí odkaz:
https://doaj.org/article/10bc2306d18e432dbaa5a6c3fa933174
Autor:
Malvika Sardana, Louise Breuil, Sébastien Goutal, Maud Goislard, Mikhail Kondrashov, Etienne Marchal, Florent L. Besson, Christophe Dugave, Gail Wrigley, Anna C. Jonson, Bertrand Kuhnast, Magnus Schou, Nicolas Tournier, Charles S. Elmore, Fabien Caillé
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1568 (2022)
Crizotinib is a tyrosine kinase inhibitor approved for the treatment of non-small-cell lung cancer, but it is inefficient on brain metastases. Crizotinib is a substrate of the P-glycoprotein, and non-invasive nuclear imaging can be used to assess the
Externí odkaz:
https://doaj.org/article/656bb5c2d5524b698cef9f5f5f03ef39
Autor:
Magnus Schou, Pär Ewing, Zsolt Cselenyi, Markus Fridén, Akihiro Takano, Christer Halldin, Lars Farde
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Background Positron emission tomography (PET) is a non-invasive molecular imaging technique that traces the distribution of radiolabeled molecules in experimental animals and human subjects. We hypothesized that PET could be used to visualiz
Externí odkaz:
https://doaj.org/article/b5670c54e71a4432942d0c3a22be322f
Autor:
Mahabuba Jahan, Peter Johnström, Ram K. Selvaraju, Marie Svedberg, Maria Sörhede Winzell, Jenny Bernström, Lee Kingston, Magnus Schou, Zhisheng Jia, Stanko Skrtic, Lars Johansson, Olle Korsgren, Lars Farde, Christer Halldin, Olof Eriksson
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Background The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. Methods The binding characteristics of the selected can
Externí odkaz:
https://doaj.org/article/adeebd397411476c89f34e68e0105f08
Synthesis and Preclinical Evaluation of [11C]AZ11895530 for PET Imaging of the Serotonin 1A Receptor
Autor:
Kenneth Dahl, Peter Johnström, Anton Forsberg-Morén, Björn Gustafsson, Patricia Miranda-Azpiazu, Yaser Khani, Christer Halldin, Lars Farde, Charles S. Elmore, Magnus Schou
Publikováno v:
ACS Chemical Neuroscience. 13:2078-2083
Autor:
Darren A.E. Cross, Zack Cheng, Lars Farde, Paul D. Smith, James W.T. Yates, Richard A. Ward, M. Raymond V. Finlay, Natasha A. Karp, Albert D. Windhorst, Mohammad Mahdi Moein, Ana Vazquez-Romero, Evgeny Revunov, Jonas Malmquist, Mikhail Kondrashov, Ryosuke Arakawa, Akihiro Takano, Aaron Smith, Joanne Wilson, Annika Janefeldt, Lin Zhang, James Atkinson, Peter Barton, Gareth Maglennon, Don X. Nguyen, Minghui Zhao, Sally J. Adua, Katarina Varnäs, Richard Goodwin, Magnus Schou, Gail L. Wrigley, Yumei Yan, Nicole Strittmatter, Peter Johnström, Kan Chen, Nicola Colclough
Purpose:Osimertinib is a potent and selective EGFR tyrosine kinase inhibitor (EGFR-TKI) of both sensitizing and T790M resistance mutations. To treat metastatic brain disease, blood–brain barrier (BBB) permeability is considered desirable for increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e99bce52b9e8d79380691bf89afec19
https://doi.org/10.1158/1078-0432.c.6528456
https://doi.org/10.1158/1078-0432.c.6528456
Autor:
Darren A.E. Cross, Zack Cheng, Lars Farde, Paul D. Smith, James W.T. Yates, Richard A. Ward, M. Raymond V. Finlay, Natasha A. Karp, Albert D. Windhorst, Mohammad Mahdi Moein, Ana Vazquez-Romero, Evgeny Revunov, Jonas Malmquist, Mikhail Kondrashov, Ryosuke Arakawa, Akihiro Takano, Aaron Smith, Joanne Wilson, Annika Janefeldt, Lin Zhang, James Atkinson, Peter Barton, Gareth Maglennon, Don X. Nguyen, Minghui Zhao, Sally J. Adua, Katarina Varnäs, Richard Goodwin, Magnus Schou, Gail L. Wrigley, Yumei Yan, Nicole Strittmatter, Peter Johnström, Kan Chen, Nicola Colclough
Supplementary Figure S1 - Structure and position of label for compounds assessed for BBB penetrance in non human primates (NHP). Majority of compounds were labelled with carbon-11 except afatinib which was labelled with fluorine-18. (*) Indicates pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f25e8e82af5345d6a7e68e8c3a46ea5
https://doi.org/10.1158/1078-0432.22473252
https://doi.org/10.1158/1078-0432.22473252