Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Magnus, Rattray"'
Autor:
Mauro Tutino, Jenny Hankinson, Clare Murray, Lesley Lowe, Gina Kerry, Magnus Rattray, Adnan Custovic, Sebastian L. Johnston, Chenfu Shi, Gisela Orozco, Stephen Eyre, Paul Martin, Angela Simpson, John A. Curtin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Functional enrichment analysis of genome-wide association study (GWAS)-summary statistics has suggested that CD4+ T-cells play an important role in asthma pathogenesis. Despite this, CD4+ T-cells are under-represented in asthma transcriptome
Externí odkaz:
https://doaj.org/article/c7ac37edc530414aabe9f0ab3891436c
Autor:
Lijing Lin, John A. Curtin, Eteri Regis, Aurica Hirsman, Rebecca Howard, Mauro Tutino, Michael R. Edwards, Mattia Prosperi, Angela Simpson, Magnus Rattray, Adnan Custovic, Sebastian L. Johnston
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Patterns of human immune responses to viruses and bacteria and how this impacts risk of infections or onset/exacerbation of chronic respiratory diseases are poorly understood. In a population-based birth cohort, we measured peripheral blood
Externí odkaz:
https://doaj.org/article/962569f4566642efb4f9f8b58782ec23
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112382- (2023)
Summary: Dosage compensation, the balancing of X-linked gene expression between sexes and to the autosomes, is critical to an organism’s fitness and survival. In Drosophila, dosage compensation involves hypertranscription of the male X chromosome.
Externí odkaz:
https://doaj.org/article/11b317e5b51240e388482d81b8ca4dcd
Autor:
Lauren Forbes Beadle, Jennifer C Love, Yuliya Shapovalova, Artem Artemev, Magnus Rattray, Hilary L Ashe
Publikováno v:
PLoS Biology, Vol 21, Iss 1, p e3001956 (2023)
Regulation of mRNA degradation is critical for a diverse array of cellular processes and developmental cell fate decisions. Many methods for determining mRNA half-lives rely on transcriptional inhibition or metabolic labelling. Here, we use a non-inv
Externí odkaz:
https://doaj.org/article/da389f194bd547d28a6e4596d4a3ccd0
Autor:
Eteri Regis, Sara Fontanella, Lijing Lin, Rebecca Howard, Sadia Haider, John A. Curtin, Michael R. Edwards, Magnus Rattray, Angela Simpson, Adnan Custovic, Sebastian L. Johnston
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The mechanisms explaining excess morbidity and mortality in respiratory infections among males are poorly understood. Innate immune responses are critical in protection against respiratory virus infections. We hypothesised that innate immune
Externí odkaz:
https://doaj.org/article/e667c858cf0341aaa467bae5485baa98
Autor:
Sayema Rahman, Norman van Rhijn, Panagiotis Papastamoulis, Darren D. Thomson, Zorana Carter, Rachael Fortune-Grant, Magnus Rattray, Michael John Bromley, Elaine Bignell
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Damage to the lung epithelium is a unifying feature of disease caused by the saprophytic fungus Aspergillus fumigatus. However, the mechanistic basis and the regulatory control of such damage is poorly characterized. Previous studies have identified
Externí odkaz:
https://doaj.org/article/e35ba8913ed0458ab3948445b0b9f1ce
Autor:
Jing Yang, Amanda McGovern, Paul Martin, Kate Duffus, Xiangyu Ge, Peyman Zarrineh, Andrew P. Morris, Antony Adamson, Peter Fraser, Magnus Rattray, Stephen Eyre
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Although genome-wide association studies have identified genetic variation contributing to disease risk, assigning causal genes is challenging. Here, the authors generate ATAC-seq, Hi-C, Capture Hi-C and RNA-seq data in stimulated CD4+ T cells to ide
Externí odkaz:
https://doaj.org/article/cfb2cf5b4bb44d5cacaff7677eed292d
Publikováno v:
BMC Bioinformatics, Vol 21, Iss S10, Pp 1-19 (2020)
Abstract Background Oscillatory genes, with periodic expression at the mRNA and/or protein level, have been shown to play a pivotal role in many biological contexts. However, with the exception of the circadian clock and cell cycle, only a few such g
Externí odkaz:
https://doaj.org/article/129c1bd1b85642938e04a9589c549a45
Autor:
Cerys S. Manning, Veronica Biga, James Boyd, Jochen Kursawe, Bodvar Ymisson, David G. Spiller, Christopher M. Sanderson, Tobias Galla, Magnus Rattray, Nancy Papalopulu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
The single-cell gene expression changes during spinal cord formation and neurogenesis in mice are unclear. Here, the authors use a HES5 reporter to live image, then mathematically model, oscillations in single cells in presumed progenitors and neuron
Externí odkaz:
https://doaj.org/article/625df354e8904d6d8d48ca404cd12312
Autor:
Toryn M. Poolman, Julie Gibbs, Amy L. Walker, Suzanna Dickson, Laura Farrell, James Hensman, Alexandra C. Kendall, Robert Maidstone, Stacey Warwood, Andrew Loudon, Magnus Rattray, Ian N. Bruce, Anna Nicolaou, David W. Ray
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-13 (2019)
Abstract Objective We applied systems biology approaches to investigate circadian rhythmicity in rheumatoid arthritis (RA). Methods We recruited adults (age 16–80 years old) with a clinical diagnosis of RA (active disease [DAS28 > 3.2]). Sleep prof
Externí odkaz:
https://doaj.org/article/b5324101ab5f45db9ba080420254aff4