An agent-based modelling framework to study growth mechanisms in EGFR-L858R mutant alveolar type II cells

Autor: Coggan, Helena, Weeden, Clare E., Pearce, Philip, Dalwadi, Mohit P., Magness, Alastair, Swanton, Charles, Page, Karen M.

Mutations in the epidermal growth factor receptor (EGFR) are common in non-small cell lung cancer (NSCLC), particularly in never-smoker patients. However, these mutations are not always carcinogenic, and have recently been reported in histologically

Externí odkaz: http://arxiv.org/abs/2303.11342

Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX

Autor: Alastair Magness, Emma Colliver, Katey S. S. Enfield, Claudia Lee, Masako Shimato, Emer Daly, David A. Moore, Monica Sivakumar, Karishma Valand, Dina Levi, Crispin T. Hiley, Philip S. Hobson, Febe van Maldegem, James L. Reading, Sergio A. Quezada, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract The growing scale and dimensionality of multiplexed imaging require reproducible and comprehensive yet user-friendly computational pipelines. TRACERx-PHLEX performs deep learning-based cell segmentation (deep-imcyto), automated cell-type ann

Externí odkaz: https://doaj.org/article/f61b4b8bd2f54cbd9679706490019396

Extending a problem of Pillai to Gaussian lines

Autor: Magness, Elsa, Nugent, Brian, Robertson, Leanne

Let $L$ be a primitive Gaussian line, that is, a line in the complex plane that contains two, and hence infinitely many, coprime Gaussian integers. We prove that there exists an integer $G_L$ such that for every integer $n\geq G_L$ there are infinite

Externí odkaz: http://arxiv.org/abs/2207.00045

An Interview with Francis Wilson

Autor: Magness, Phillip, Gartz, Micha

Publikováno v: Research in the History of Economic Thought and Methodology: Including a Selection of Papers Presented at the First History of Economics Diversity Caucus Conference

Externí odkaz: http://www.emeraldinsight.com/doi/10.1108/S0743-41542023000041B010

DISP1 deficiency: Monoallelic and biallelic variants cause a spectrum of midline craniofacial malformations

Autor: Lavillaureix, Alinoë, Rollier, Paul, Kim, Artem, Panasenkava, Veranika, De Tayrac, Marie, Carré, Wilfrid, Guyodo, Hélène, Faoucher, Marie, Poirel, Elisabeth, Akloul, Linda, Quélin, Chloé, Whalen, Sandra, Bos, Jessica, Broekema, Marjoleine, van Hagen, Johanna M., Grand, Katheryn, Allen-Sharpley, Michelle, Magness, Emily, McLean, Scott D., Kayserili, Hülya, Altunoglu, Umut, En Qi Chong, Angie, Xue, Shifeng, Jeanne, Médéric, Almontashiri, Naif, Habhab, Wisam, Vanlerberghe, Clemence, Faivre, Laurence, Viora-Dupont, Eléonore, Philippe, Christophe, Safraou, Hana, Laffargue, Fanny, Mittendorf, Luisa, Abou Jamra, Rami, Patil, Siddaramappa Jagdish, Dalal, Ashwin, Sarma, Asodu Sandeep, Keren, Boris, Reversade, Bruno, Dubourg, Christèle, Odent, Sylvie, Dupé, Valérie

Publikováno v: In Genetics in Medicine July 2024 26(7)