Sustained mucosal colonization and fecal metabolic dysfunction by Bacteroides associates with fecal microbial transplant failure in ulcerative colitis patients.

Autor: Zhang B; Department of Medicine, Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA., Magnaye KM; Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; The Benioff Center for Microbiome Medicine, University of California San Francisco, San Francisco, CA, 94143, USA., Stryker E; Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA., Moltzau-Anderson J; Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; The Benioff Center for Microbiome Medicine, University of California San Francisco, San Francisco, CA, 94143, USA., Porsche CE; Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA., Hertz S; Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark., McCauley KE; Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA., Smith BJ; The Gladstone Institutes, Data Science and Biotechnology, San Francisco, CA, 94158, USA., Zydek M; Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA., Pollard KS; The Gladstone Institutes, Data Science and Biotechnology, San Francisco, CA, 94158, USA.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, 94158, USA.; Chan Zuckerberg Biohub, San Francisco, CA University of California, San Francisco, CA, 94158, USA., Ma A; Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA., El-Nachef N; Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; Division of Gastroenterology, Henry Ford Health System, Detroit, MI, 48208, USA., Lynch SV; Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA. susan.lynch@ucsf.edu.; The Benioff Center for Microbiome Medicine, University of California San Francisco, San Francisco, CA, 94143, USA. susan.lynch@ucsf.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Aug 09; Vol. 14 (1), pp. 18558. Date of Electronic Publication: 2024 Aug 09.

African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.

Autor: Washington C 3rd; Department of Human Genetics, The University of Chicago, 928 E. 58th St. CLSC 507C, Chicago, IL, 60637, USA., Dapas M; Department of Human Genetics, The University of Chicago, 928 E. 58th St. CLSC 507C, Chicago, IL, 60637, USA., Biddanda A; Department of Human Genetics, The University of Chicago, 928 E. 58th St. CLSC 507C, Chicago, IL, 60637, USA., Magnaye KM; Department of Human Genetics, The University of Chicago, 928 E. 58th St. CLSC 507C, Chicago, IL, 60637, USA., Aneas I; Department of Human Genetics, The University of Chicago, 928 E. 58th St. CLSC 507C, Chicago, IL, 60637, USA., Helling BA; Department of Human Genetics, The University of Chicago, 928 E. 58th St. CLSC 507C, Chicago, IL, 60637, USA., Szczesny B; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Boorgula MP; Department of Medicine, University of Colorado Denver, Aurora, CO, USA., Taub MA; Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA., Kenny E; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mathias RA; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Barnes KC; Department of Medicine, University of Colorado Denver, Aurora, CO, USA., Khurana Hershey GK; Division of Asthma Research, Cincinnati Children's Hospital, Cincinnati, OH, USA., Kercsmar CM; Division of Asthma Research, Cincinnati Children's Hospital, Cincinnati, OH, USA., Gereige JD; Department of Medicine, Division of Pulmonary, Allergy, Sleep, and Critical Care Medicine, Boston University School of Medicine, Boston, MA, USA., Makhija M; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Gruchalla RS; University of Texas Southwestern Medical Center, Dallas, TX, USA., Gill MA; University of Texas Southwestern Medical Center, Dallas, TX, USA., Liu AH; Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO, USA., Rastogi D; Children's National Hospital and George Washington University School of Medicine and Health Sciences, Washington, DC, USA., Busse W; University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Gergen PJ; NIH/NIAID, Bethesda, MD, USA., Visness CM; Rho Federal Systems Division, Inc, Durham, NC, USA., Gold DR; The Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Hartert T; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA., Johnson CC; Department of Public Health Sciences, Henry Ford Health Systems, Detroit, MI, USA., Lemanske RF Jr; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Martinez FD; Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA., Miller RL; Department of Medicine, Division of Clinical Immunology Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ownby D; Department of Public Health Sciences, Henry Ford Health Systems, Detroit, MI, USA., Seroogy CM; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Wright AL; Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA., Zoratti EM; Department of Medicine, Henry Ford Health Systems, Detroit, MI, USA., Bacharier LB; Department of Pediatrics, Monroe Carell Jr Children's Hospital at Vanderbilt University Medical Center, Nashville, TN, USA., Kattan M; Department of Pediatrics, Columbia University Medical Center, New York, NY, USA., O'Connor GT; Pulmonary Center, Boston University School of Medicine, Boston, MA, USA., Wood RA; Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA., Nobrega MA; Department of Human Genetics, The University of Chicago, 928 E. 58th St. CLSC 507C, Chicago, IL, 60637, USA., Altman MC; Immunology Division, Benaroya Research Institute Systems, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Jackson DJ; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Gern JE; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., McKennan CG; Department of Statistics, University of Pittsburgh, Pittsburgh, PA, USA., Ober C; Department of Human Genetics, The University of Chicago, 928 E. 58th St. CLSC 507C, Chicago, IL, 60637, USA. c-ober@genetics.uchicago.edu.

Publikováno v: Genome medicine [Genome Med] 2022 Sep 29; Vol. 14 (1), pp. 112. Date of Electronic Publication: 2022 Sep 29.

Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region.

Autor: Aneas I; Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA. ianeas@bsd.uchicago.edu., Decker DC; Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, 60637, USA., Howard CL; Committee on Immunology, University of Chicago, Chicago, IL, 60637, USA., Sobreira DR; Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA., Sakabe NJ; Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA., Blaine KM; Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, 60637, USA., Stein MM; Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA., Hrusch CL; Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, 60637, USA., Montefiori LE; Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA., Tena J; Centro Andaluz de Biología del Desarrollo (CSIC/UPO/JA), Universidad Pablo de Olavide, Seville, 41013, Spain., Magnaye KM; Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA., Clay SM; Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA., Gern JE; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53726, USA., Jackson DJ; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53726, USA., Altman MC; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Naureckas ET; Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, 60637, USA., Hogarth DK; Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, 60637, USA., White SR; Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, 60637, USA., Gomez-Skarmeta JL; Centro Andaluz de Biología del Desarrollo (CSIC/UPO/JA), Universidad Pablo de Olavide, Seville, 41013, Spain., Schoetler N; Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, 60637, USA., Ober C; Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA., Sperling AI; Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, 60637, USA. asperlin@uchicago.edu.; Committee on Immunology, University of Chicago, Chicago, IL, 60637, USA. asperlin@uchicago.edu., Nóbrega MA; Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA. nobrega@uchicago.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Oct 21; Vol. 12 (1), pp. 6115. Date of Electronic Publication: 2021 Oct 21.

Fungus fuels mucosal wounds in Crohn's disease.

Autor: Magnaye KM; Department of Medicine, University of California, San Francisco, CA, USA., Lynch SV; Department of Medicine, University of California, San Francisco, CA, USA. Electronic address: susan.lynch@ucsf.edu.

Publikováno v: Immunity [Immunity] 2021 May 11; Vol. 54 (5), pp. 856-858.

Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.

Autor: Ober C; Department of Human Genetics, University of Chicago, Chicago, IL, USA. Electronic address: c-ober@genetics.uchicago.edu., McKennan CG; Department of Statistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Magnaye KM; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Altman MC; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA., Washington C 3rd; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Stanhope C; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Naughton KA; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Rosasco MG; Systems Immunology Program, Benaroya Research Institute, Seattle, WA, USA., Bacharier LB; Division of Pediatric Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University and St Louis Children's Hospital, St Louis, MO, USA., Billheimer D; College of Public Health, University of Arizona, Tucson, AZ, USA; BIO5 Institute, University of Arizona, Tucson, AZ, USA., Gold DR; The Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T H Chan School of Public Health, Boston, MA, USA., Gress L; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Hartert T; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA., Havstad S; Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA., Khurana Hershey GK; Division of Asthma Research, Cincinnati Children's Hospital and Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA., Hallmark B; College of Public Health, University of Arizona, Tucson, AZ, USA; BIO5 Institute, University of Arizona, Tucson, AZ, USA., Hogarth DK; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA., Jackson DJ; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Johnson CC; Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA., Kattan M; Department of Pediatrics, Columbia University Medical Center, New York, NY, USA., Lemanske RF; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Lynch SV; Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Mendonca EA; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA; Department of Pediatrics and Biostatistics, Indiana University, Indianapolis, IN, USA; Regenstrief Institute, Indianapolis, IN, USA., Miller RL; Department of Medicine, Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Naureckas ET; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA., O'Connor GT; Department of Pediatrics, Boston University, Boston, MA, USA., Seroogy CM; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Wegienka G; Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA., White SR; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA., Wood RA; Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA., Wright AL; Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA., Zoratti EM; Division of Allergy and Clinical Immunology, Henry Ford Health System, Detroit, MI, USA., Martinez FD; Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA; BIO5 Institute, University of Arizona, Tucson, AZ, USA., Ownby D; Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA., Nicolae DL; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Levin AM; Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA., Gern JE; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Publikováno v: The Lancet. Respiratory medicine [Lancet Respir Med] 2020 May; Vol. 8 (5), pp. 482-492.