ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer.

Autor: Purohit V; Perlmutter Cancer Center, New York University, New York, New York 10016, USA., Wang L; Perlmutter Cancer Center, New York University, New York, New York 10016, USA., Yang H; Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA., Li J; Perlmutter Cancer Center, New York University, New York, New York 10016, USA., Ney GM; Department of Pediatric Oncology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA., Gumkowski ER; Department of Molecular and Integrative Physiology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA., Vaidya AJ; Department of Molecular and Integrative Physiology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA., Wang A; Perlmutter Cancer Center, New York University, New York, New York 10016, USA.; Department of Surgery, New York University, New York, New York 10016, USA., Bhardwaj A; Perlmutter Cancer Center, New York University, New York, New York 10016, USA., Zhao E; Perlmutter Cancer Center, New York University, New York, New York 10016, USA., Dolgalev I; Perlmutter Cancer Center, New York University, New York, New York 10016, USA., Zamperone A; Perlmutter Cancer Center, New York University, New York, New York 10016, USA., Abel EV; Department of Molecular and Integrative Physiology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA., Magliano MPD; Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA., Crawford HC; Department of Molecular and Integrative Physiology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA.; Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109, USA., Diolaiti D; Perlmutter Cancer Center, New York University, New York, New York 10016, USA., Papagiannakopoulos TY; Perlmutter Cancer Center, New York University, New York, New York 10016, USA.; Department of Pathology, New York University, New York, New York 10016, USA., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA.; Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109, USA., Simeone DM; Perlmutter Cancer Center, New York University, New York, New York 10016, USA.; Department of Surgery, New York University, New York, New York 10016, USA.; Department of Pathology, New York University, New York, New York 10016, USA.

Publikováno v: Genes & development [Genes Dev] 2021 Feb 01; Vol. 35 (3-4), pp. 218-233. Date of Electronic Publication: 2021 Jan 14.