TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest

Autor: Alessio De Magis, Philipp Schult, Antonia Schönleber, Rebecca Linke, Kerstin U. Ludwig, Beate M. Kümmerer, Katrin Paeschke

Publikováno v: BMC Biology, Vol 22, Iss 1, Pp 1-18 (2024)

Abstract Background SARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2, TMPRSS2. Potential inhibitors of these proteins would be ideal targets against severe acute respir

Externí odkaz: https://doaj.org/article/482e5826db224a729a72cbb3f46861e9

Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study

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Ingram, Ketteria D., Javia, Vidhi N., Jeter, Mykayla, Johnson, Brandi, Joseph, Yasha, Juarez, Monica, Kajan, Dana, Khalil, Lana, Kirkpatrick, Caitlin M., Kleinhenz, Dean, Kolailat, Imanii, Koumanelis, Athena, Koumanelis, Alexandra, Kozoman, Rebecca, Krishnan, Shilpa, Lainez, Jordi, Lawrence, Brianna, Lee, Matthew A., Leon, Jose D., Lew, Valerie, Lewis, Kennedy C., Litvack, Matthew, Maroney, Mara, Maier, Cheryl L., Makkaoui, Nour, Marconi, Vincent C., Martin, Christopher F., Martinez, Monica, Mbogo, Loice, McCaslin, Atuarra, McIntyre, Jerrod, Moanna, Abeer, Montoya, Miranda, Morales, Elena, Moran, Caitlin A., Morgan-Billingslea, Jan, Murray, Calista, Nelson, Roslin, Neuman, Robert B., Nguyen, Tran, Ofotokun, Ighovwerha, Ojemakinde, Elizabeth I., Ojoawo, Bukkie, Osinski, Eileen, Oviedo, Sofia, Panganiban, Bernadine, Paredes-Gaitan, Yolanda, Patzer, Rachel E., Pemu, Priscilla, Prude, Michael, Rahman, Kazi, Ramakrishnan, Grace, Rebolledo, Paulina A., Roberts, Marjorie, Robinson, Keysha, 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Publikováno v: In Clinical Microbiology and Infection December 2024 30(12):1599-1605

Combining methylated SEPTIN9 and RNF180 plasma markers for diagnosis and early detection of gastric cancer

Autor: Yongzhan Nie, Xianchun Gao, Xiqiang Cai, Zhen Wu, Qiaoyi Liang, Guobing Xu, Na Liu, Peng Gao, Jingyu Deng, Hongzhi Xu, Zhanlong Shen, Changqi Cao, Fenrong Chen, Nannan Zhang, Yongxi Song, Mingjun Sun, Chengyin Liu, Guangpeng Zhou, Weili Han, Jianhua Dou, Huahong Xie, Liping Yao, Zhiguo Liu, Gang Ji, Xin Wang, Qingchuan Zhao, Lei Shang, Daiming Fan, Xiaoliang Han, Jianlin Ren, Han Liang, Zhenning Wang, Jinhai Wang, Qi Wu, Jun Yu, Kaichun Wu, the MAGIS Study Group

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Externí odkaz: https://doaj.org/article/d1f798d0cd764006824479644ef60bb3

Safety and Efficacy of Clofazimine as an Alternative for Rifampicin in Mycobacterium avium Complex Pulmonary Disease Treatment: Outcomes of a Randomized Trial

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The top-scoring ‘N’ algorithm: a generalized relative expression classification method from small numbers of biomolecules

Autor: Magis Andrew T, Price Nathan D

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Abstract Background Relative expression algorithms such as the top-scoring pair (TSP) and the top-scoring triplet (TST) have several strengths that distinguish them from other classification methods, including resistance to overfitting, invariance to

Externí odkaz: https://doaj.org/article/f46a5d7d5b5c44be800b3f20e1aa3a45