Zobrazeno 1 - 10
of 12 320
pro vyhledávání: '"Magid A"'
Autor:
Abdullah F. AlAsmari, Mohammed M. Alshehri, Nemat Ali, Fawaz AlAsmari, Youssef Sari, Wayne E. Childers, Magid Abou-Gharbia, Metab Alharbi, Doaa M. Elnagar, Wejdan S. AL-Qahtani
Publikováno v:
Saudi Pharmaceutical Journal, Vol 32, Iss 9, Pp 102148- (2024)
Drug addiction is considered a worldwide concern and one of the most prevailing causes of death globally. Opioids are highly addictive drugs, and one of the most common opioids that is frequently used clinically is fentanyl. The potential harmful eff
Externí odkaz:
https://doaj.org/article/c63508a0c0d94682a615fb4bd5952e18
Autor:
Youssef Sari, Ghadeer M.S. Swiss, Fatin A. Alrashedi, Kholoud A. Baeshen, Sultan A. Alshammari, Shakir D. Alsharari, Nemat Ali, Abdullah F. Alasmari, Ali Alhoshani, Alaa A. Alameen, Wayne E. Childers, Magid Abou-Gharbia, Fawaz Alasmari
Publikováno v:
Saudi Pharmaceutical Journal, Vol 32, Iss 7, Pp 102108- (2024)
Chronic exposure to opioids can lead to downregulation of astrocytic glutamate transporter 1 (GLT-1), which regulates the majority of glutamate uptake. Studies from our lab revealed that beta-lactam antibiotic, ceftriaxone, attenuated hydrocodone-ind
Externí odkaz:
https://doaj.org/article/94fe24dfa97e4428abb4e5154021949d
Autor:
Hanghang Zhang, Chen Huang, John Gordon, Sijia Yu, George Morton, Wayne Childers, Magid Abou-Gharbia, Yi Zhang, Jaroslav Jelinek, Jean-Pierre J. Issa
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Inhibition of cyclin-dependent kinase 9 (CDK9), a novel epigenetic target in cancer, can reactivate epigenetically silenced genes in cancer by dephosphorylating the SWI/SNF chromatin remodeler BRG1. Here, we characterized the anti
Externí odkaz:
https://doaj.org/article/892c78200eb14c6280a512cb5e5194fd
Autor:
Shelby Travaglianti, Ahmed Alotaibi, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Youssef Sari
Publikováno v:
Brain Research Bulletin, Vol 211, Iss , Pp 110935- (2024)
Chronic ethanol consumption can lead to increased extracellular glutamate concentrations in key reward brain regions, such as medial prefrontal cortex (mPFC) and nucleus accumbens (NAc), and consequently leading to oxidative stress and neuroinflammat
Externí odkaz:
https://doaj.org/article/9d8e6c3717c14b58b334e7a4fcbbdf77
Autor:
Mohammed S. Alasmari, Fawaz Alasmari, Shakir D. Alsharari, Abdullah F. Alasmari, Nemat Ali, Syed Rizwan Ahamad, Abdullah M. Alghamdi, Aban A. Kadi, Alaa M. Hammad, Yousif S. Mohamed Ali, Wayne E. Childers, Magid Abou-Gharbia, Youssef Sari
Publikováno v:
Toxics, Vol 12, Iss 8, p 604 (2024)
Opioid-related deaths are attributed to overdoses, and fentanyl overdose has been on the rise in many parts of the world, including the USA. Glutamate transporter 1 (GLT-1) has been identified as a therapeutic target in several preclinical models of
Externí odkaz:
https://doaj.org/article/f00966e2d097485eb570a59f9dccf2b0
Autor:
Randa Kaf, Ola Harb, Magid Ali, Nashaat Salama, Taha Baiomy, Marwa Abdelgawad, Lobna Abdelaziz
Publikováno v:
Middle East Journal of Cancer, Vol 13, Iss 2, Pp 237-246 (2022)
Background: Gankyrin is an oncoprotein incriminated in cancer growth, invasion, and spread. Snail1 is associated with mesenchymal features acquisition that is related to invasion and metastasis of malignant cells. Isocitrate dehydrogenase 1(IDH1) has
Externí odkaz:
https://doaj.org/article/e1d223a947d2431496bc74a9e39caa73
Autor:
Elaine M. Pascoe, Steven J. Chadban, Magid A. Fahim, Carmel M. Hawley, David W. Johnson, Michael G. Collins, for the BEST-fluids Investigators and the Australasian Kidney Trials Network
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-4 (2022)
Abstract Background Delayed graft function, or the requirement for dialysis due to poor kidney function, is a frequent complication of deceased donor kidney transplantation that is associated with inferior outcomes. Intravenous fluids with a high chl
Externí odkaz:
https://doaj.org/article/860742f4888641d5b7636a1556e5852b
Autor:
Malek Z O Hassan, Ahmed Tawakol, Ying Wang, Raza M Alvi, Magid Awadalla, Maeve Jones-O'Connor, Rula B Bakar, Dahlia Banerji, Adam Rokicki, Lili Zhang, Connor P Mulligan, Michael T Osborne, Azmaeen Zarif, Basma Hammad, Annie W Chan, Lori J Wirth, Erica T Warner, Roger K Pitman, Katrina A Armstrong, Daniel Addison, Tomas G Neilan
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0279235 (2023)
ImportanceThe mechanisms underlying the association between chronic stress and higher mortality among individuals with cancer remain incompletely understood.ObjectiveTo test the hypotheses that among individuals with active head and neck cancer, that
Externí odkaz:
https://doaj.org/article/124443f4e6884192b4caaaaad8edda33
Autor:
Magid, Salma Abdel, Pan, Weiwei, Warchol, Simon, Guo, Grace, Kim, Junsik, Rahman, Mahia, Pfister, Hanspeter
Text-to-image (T2I) models are increasingly used in impactful real-life applications. As such, there is a growing need to audit these models to ensure that they generate desirable, task-appropriate images. However, systematically inspecting the assoc
Externí odkaz:
http://arxiv.org/abs/2410.04634
Autor:
Michael G. Collins, PhD, Magid A. Fahim, PhD, Elaine M. Pascoe, MBiostats, Carmel M. Hawley, MMedSc, David W. Johnson, PhD, Julie Varghese, BHMS, Laura E. Hickey, BSc, Philip A. Clayton, PhD, John S. Gill, MD, Kathryn B. Dansie, MBiostats, Rachael C. McConnochie, MN, Liza A Vergara, PhD, Charani Kiriwandeniya, BSc, Donna Reidlinger, MPH, Peter F. Mount, PhD, Laurence Weinberg, PhD, Colin J. McArthur, MBChB, P. Toby Coates, PhD, Zoltan H. Endre, PhD, David Goodman, PhD, Kirsten Howard, PhD, Martin Howell, PhD, Jagadish S. Jamboti, DM, John Kanellis, PhD, Jerome M. Laurence, PhD, Wai H. Lim, PhD, Steven J. McTaggart, PhD, Philip J. O’Connell, PhD, Helen L. Pilmore, MD, Germaine Wong, PhD, Steven J. Chadban, PhD, on behalf of the BEST-Fluids Investigators and the Australasian Kidney Trials Network
Publikováno v:
Transplantation Direct, Vol 8, Iss 12, p e1399 (2022)
Background. Delayed graft function (DGF) is a major complication of deceased donor kidney transplantation. Saline (0.9% sodium chloride) is a commonly used intravenous fluid in transplantation but may increase the risk of DGF because of its high chlo
Externí odkaz:
https://doaj.org/article/79d23263695a4790a2168553fa36d255