Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Maghawry, Hegazy"'
Autor:
Asmaa A. Mandour, Ibrahim F. Nassar, Mohammed T. Abdel Aal, Mahmoud A. E. Shahin, Wael A. El-Sayed, Maghawry Hegazy, Amr Mohamed Yehia, Ahmed Ismail, Mohamed Hagras, Eslam B. Elkaeed, Hanan M. Refaat, Nasser S. M. Ismail
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1957-1973 (2022)
Cyclin-dependent kinase inhibition is considered a promising target for cancer treatment for its crucial role in cell cycle regulation. Pyrazolo pyrimidine derivatives were well established for their antitumor activity via CDK2 inhibition. In this re
Externí odkaz:
https://doaj.org/article/1e6ab14dd8874e4886ee7d210668ea2f
Autor:
Omnia R. Elbatrawy, Mohamed Hagras, Moshira A. El Deeb, Fatimah Agili, Maghawry Hegazy, Ahmed A. El-Husseiny, Mahmoud Mohamed Mokhtar, Samy Y. Elkhawaga, Ibrahim H. Eissa, Samar El-Kalyoubi
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 966 (2023)
Background: Histone deacetylase inhibitors (HDACIs) are a relatively new class of potential drugs for treating cancer. Aim: Discovery of new anticancer agents targeting HDAC. Methods: New uracil and thiouracil derivatives panels were designed and syn
Externí odkaz:
https://doaj.org/article/aaf9f96a1e06487090579a384e6ac32f
Autor:
Eman M Azmy, Ibrahim F Nassar, Mohamed Hagras, Iten M Fawzy, Maghawry Hegazy, Mahmoud Mohamed Mokhtar, Amr Mohamed Yehia, Nasser SM Ismail, Walaa H Lashin
Publikováno v:
Future Medicinal Chemistry. 15:473-495
Background: Alzheimer's disease is a neurological disorder that causes brain cells to shrink and die. Aim: Thirteen novel ‘oxathiolanyl’, ‘pyrazolyl’ and ‘pyrimidinyl’ indole derivatives were designed and synthesized as anti-Alzheimer's d
Autor:
Ibrahim F. Nassar, Mohammed T. Abdel Aal, Wael A. El-Sayed, Mahmoud A. E Shahin, Elsayed G. E. Elsakka, Mahmoud Mohamed Mokhtar, Maghawry Hegazy, Mohamed Hagras, Asmaa A. Mandour, Nasser S. M. Ismail
Publikováno v:
RSC Advances. 12:14865-14882
A new set of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffolds (4–13) as well as the thioglycoside derivatives (14, 15) were designed, and synthesized as novel CDK2 targeting compounds.
Autor:
Maghawry Hegazy, Mohamed A. Elkady, Amr Mohamed Yehia, Elsayed G.E. Elsakka, Ahmed I. Abulsoud, Nourhan M. Abdelmaksoud, Ahmed Elshafei, Tamer M. Abdelghany, Samy Y. Elkhawaga, Ahmed Ismail, Mahmoud Mohamed Mokhtar, Hesham A. El-Mahdy, Ahmed S. Doghish
Publikováno v:
Pathology - Research and Practice. 246:154510
Autor:
Ahmed S. Doghish, Maghawry Hegazy, Ahmed Ismail, Hesham A. El-Mahdy, Elsayed G.E. Elsakka, Samy Y. Elkhawaga, Mohamed A. Elkady, Amr Mohamed Yehia, Nourhan M. Abdelmaksoud, Mahmoud Mohamed Mokhtar
Publikováno v:
Pathology - Research and Practice. 245:154442
Autor:
Ahmed S. Doghish, Hesham A. El-Mahdy, Ahmed Ismail, Maghawry Hegazy, Mahmoud Mohamed Mokhtar, Samy Y. Elkhawaga, Mohamed A. Elkady, Amr Mohamed Yehia, Elsayed G.E. Elsakka
Publikováno v:
Pathology - Research and Practice. 243:154371
Autor:
Ibrahim F, Nassar, Mohammed T, Abdel Aal, Wael A, El-Sayed, Mahmoud, A E Shahin, Elsayed G E, Elsakka, Mahmoud Mohamed, Mokhtar, Maghawry, Hegazy, Mohamed, Hagras, Asmaa A, Mandour, Nasser S M, Ismail
Publikováno v:
RSC advances. 12(23)
CDK2 inhibition is an appealing target for cancer treatment that targets tumor cells in a selective manner. A new set of small molecules featuring the privileged pyrazolo[3,4
Autor:
Elsayed G.E. Elsakka, Mahmoud Mohamed Mokhtar, Maghawry Hegazy, Ahmed Ismail, Ahmed S. Doghish
Publikováno v:
Life Sciences. 308:120923
The endocytosis mechanism is a complicated system that is essential for cell signaling and survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such as cubilin, the neonatal Fc receptor for IgG, and NaPi-IIa are impor
Autor:
Salama Abdou Salama, Bakheet E. M. Elsadek, Ahmed I. Abulsoud, Maghawry Hegazy, Mostafa M. Elshafey, Adel I. Abd Elaziz
Publikováno v:
European Journal of Pharmacology. 885:173383
Our study aimed to investigate the effect of pioglitazone (PIO) on the obesity-associated metabolic effects and whether this effect is associated with modulation of catechol O-methyl transferase (COMT) expression in the high fat diet (HFD) induced ob