Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Maggie P.Y. Lam"'
Autor:
Ying-Hsi Lin, Jennifer L. Major, Tim Liebner, Zaynab Hourani, Joshua G. Travers, Sara A. Wennersten, Korey R. Haefner, Maria A. Cavasin, Cortney E. Wilson, Mark Y. Jeong, Yu Han, Michael Gotthardt, Scott K. Ferguson, Amrut V. Ambardekar, Maggie P.Y. Lam, Chunaram Choudhary, Henk L. Granzier, Kathleen C. Woulfe, Timothy A. McKinsey
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin
Externí odkaz:
https://doaj.org/article/150af97ede814fce977a15aa3d27a1dc
Autor:
Tony Chour, Lei Tian, Edward Lau, Dilip Thomas, Ilanit Itzhaki, Olfat Malak, Joe Z. Zhang, Xulei Qin, Mirwais Wardak, Yonggang Liu, Mark Chandy, Katelyn E. Black, Maggie P.Y. Lam, Evgenios Neofytou, Joseph C. Wu
Publikováno v:
JCI Insight, Vol 6, Iss 7 (2021)
Human pluripotent stem cells (PSCs), which are composed of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), provide an opportunity to advance cardiac cell therapy–based clinical trials. However, an important hurdle that must
Externí odkaz:
https://doaj.org/article/142c0c0a2b9249b0bb2c4654a72969d8
Autor:
Edward Lau, Yu Han, Damon R. Williams, Cody T. Thomas, Rajani Shrestha, Joseph C. Wu, Maggie P.Y. Lam
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3751-3765.e5 (2019)
Summary: The protein-level translational status and function of many alternative splicing events remain poorly understood. We use an RNA sequencing (RNA-seq)-guided proteomics method to identify protein alternative splicing isoforms in the human prot
Externí odkaz:
https://doaj.org/article/52861964a42c4de8be9e40f92fcf3af2
Computation-assisted targeted proteomics of alternative splicing protein isoforms in the human heart
Publikováno v:
J Mol Cell Cardiol
Alternative splicing is prevalent in the heart and implicated in many cardiovascular diseases, but not every alternative transcript is translated and detecting non-canonical isoforms at the protein level remains challenging. Here we show the use of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f82435785652d898c565e58cd748416
https://doi.org/10.1016/j.yjmcc.2021.01.007
https://doi.org/10.1016/j.yjmcc.2021.01.007
Publikováno v:
J Vis Exp
Mass spectrometry-based shotgun proteomics experiments require multiple sample preparation steps, including enzymatic protein digestion and clean-up, which can take up significant person-hours of bench labor and present a source of batch-to-batch var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ab9f6b0e7fb77ffaec9744d752d133
https://europepmc.org/articles/PMC8986016/
https://europepmc.org/articles/PMC8986016/
Autor:
Timothy A. McKinsey, Harrison E. Smith, Deepak Srivastava, Saptarsi M. Haldar, Michael Alexanian, Blake Y. Enyart, Matthew S. Stratton, Charles Y. Lin, Andrew S. Riching, Madeleine E. Lemieux, Keith A. Koch, Maria A. Cavasin, Marina Barreto Felisbino, Maggie P.Y. Lam, Jun Qi, Kunhua Song, Rachel A. Hirsch, Rushita A. Bagchi
Publikováno v:
Circ Res
Rationale: Small molecule inhibitors of the acetyl-histone binding protein BRD4 have been shown to block cardiac fibrosis in preclinical models of heart failure (HF). However, since the inhibitors target BRD4 ubiquitously, it is unclear whether this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f43a97db48af3855bed85ab9e83a185
https://doi.org/10.1161/circresaha.119.315125
https://doi.org/10.1161/circresaha.119.315125
Autor:
Rushita A. Bagchi, Steven R. Houser, Timothy A. McKinsey, Kimberly M. Demos-Davies, Sara A. Wennersten, Maggie P.Y. Lam, Kathleen C. Woulfe, Ying-Hsi Lin, Harrison E. Smith, Luisa Mestroni, Brisa Peña, Charles Y. Lin, Joshua G. Travers, Evgenia Dobrinskikh, Rachel A. Hirsch, Maria A. Cavasin, Christian Steinkühler, Lauren A. Vanderlinden
Publikováno v:
Circulation
Background: Diastolic dysfunction (DD) is associated with the development of heart failure and contributes to the pathogenesis of other cardiac maladies, including atrial fibrillation. Inhibition of histone deacetylases (HDACs) has been shown to prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba885121a0178a699167efba5e8a4ac
https://pubmed.ncbi.nlm.nih.gov/33970677
https://pubmed.ncbi.nlm.nih.gov/33970677
Publikováno v:
STAR Protocols
STAR Protocols, Vol 1, Iss 3, Pp 100138-(2020)
STAR Protocols, Vol 1, Iss 3, Pp 100138-(2020)
Summary Alternative splicing greatly expands the coding capacity of the human genome, but how many alternative transcripts are translated as proteins or carry functional importance remains unknown and awaits experimental verification. Here, we descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e39ae2d7b3eec4323f88cca72c1b95
https://pubmed.ncbi.nlm.nih.gov/33377032
https://pubmed.ncbi.nlm.nih.gov/33377032
Autor:
Charles Y. Lin, Evgenia Dobrinskikh, Lauren A. Vanderlinden, Kimberly M Demos-Davies, Maggie P.Y. Lam, Rachel A. Hirsch, Rushita A. Bagchi, Timothy A. McKinsey, Harrison E. Smith, Steven R. Houser, Brisa Pena, Sara A Wennersten, Ying-Hsi Lin, Maria A. Cavasin, Christian Steinkühler, Luisa Mestroni, Joshua G Travers
Publikováno v:
Circulation. 142
Introduction: Diastolic dysfunction is associated with the development of heart failure with preserved ejection fraction and other cardiac maladies, including atrial fibrillation. Inhibition of histone deacetylase (HDAC) activity has previously been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b870b621402bd44b6c41ac036edbad2
https://doi.org/10.1161/circ.142.suppl_3.15707
https://doi.org/10.1161/circ.142.suppl_3.15707
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
The heart is sensitive to oxidative damage but a global view on how the cardiac proteome responds to oxidative stressors has yet to fully emerge. Using quantitative tandem mass spectrometry, we assessed the effects of acute exposure of the oxidative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a347db02375206d5dae1a4f5adad84ea
https://doi.org/10.1038/s41598-020-75505-8
https://doi.org/10.1038/s41598-020-75505-8