Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Maggie P Y, Lam"'
Autor:
Jordan Currie, Vyshnavi Manda, Sean K. Robinson, Celine Lai, Vertica Agnihotri, Veronica Hidalgo, R. W. Ludwig, Kai Zhang, Jay Pavelka, Zhao V. Wang, June-Wha Rhee, Maggie P. Y. Lam, Edward Lau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The spatial and temporal distributions of proteins are critical to protein function, but cannot be directly assessed by measuring protein bundance. Here we describe a mass spectrometry-based proteomics strategy, Simultaneous Proteome Localiz
Externí odkaz:
https://doaj.org/article/9c3fc3b65cfa49da9118e8f482871a44
Autor:
Himangi Srivastava, Michael J Lippincott, Jordan Currie, Robert Canfield, Maggie P Y Lam, Edward Lau
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010702 (2022)
Protein and mRNA levels correlate only moderately. The availability of proteogenomics data sets with protein and transcript measurements from matching samples is providing new opportunities to assess the degree to which protein levels in a system can
Externí odkaz:
https://doaj.org/article/1b1aab1632884945aea9ae8aa8c5c859
Autor:
Subash Adhikari, Edouard C. Nice, Eric W. Deutsch, Lydie Lane, Gilbert S. Omenn, Stephen R. Pennington, Young-Ki Paik, Christopher M. Overall, Fernando J. Corrales, Ileana M. Cristea, Jennifer E. Van Eyk, Mathias Uhlén, Cecilia Lindskog, Daniel W. Chan, Amos Bairoch, James C. Waddington, Joshua L. Justice, Joshua LaBaer, Henry Rodriguez, Fuchu He, Markus Kostrzewa, Peipei Ping, Rebekah L. Gundry, Peter Stewart, Sanjeeva Srivastava, Sudhir Srivastava, Fabio C. S. Nogueira, Gilberto B. Domont, Yves Vandenbrouck, Maggie P. Y. Lam, Sara Wennersten, Juan Antonio Vizcaino, Marc Wilkins, Jochen M. Schwenk, Emma Lundberg, Nuno Bandeira, Gyorgy Marko-Varga, Susan T. Weintraub, Charles Pineau, Ulrike Kusebauch, Robert L. Moritz, Seong Beom Ahn, Magnus Palmblad, Michael P. Snyder, Ruedi Aebersold, Mark S. Baker
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The Human Proteome Project (HPP) was launched in 2010 to enhance accurate annotation of the genome-encoded proteome. Ten years later, the HPP releases its first blueprint of the human proteome, annotating 90% of all known proteins at high-stringency
Externí odkaz:
https://doaj.org/article/bb037a5bb053476e9a3946b7578e5277
Autor:
Edward Lau, Quan Cao, Maggie P. Y. Lam, Jie Wang, Dominic C. M. Ng, Brian J. Bleakley, Jessica M. Lee, David A. Liem, Ding Wang, Henning Hermjakob, Peipei Ping
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Transcriptome data provide only a partial picture of disease states. Here, via integration of transcript-, protein abundance and protein turnover data for a mouse model of cardiac hypertrophy, the authors uncover additional disease gene signatures, a
Externí odkaz:
https://doaj.org/article/735fc1b56e0a42518ad0a64c538beba9
Autor:
Maggie P. Y. Lam
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 324:H863-H865
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f91241b17fc49f756a9b7fd6c1ee895
https://doi.org/10.1152/ajpheart.00210.2023
https://doi.org/10.1152/ajpheart.00210.2023
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H538-H558
The risks of heart diseases are significantly modulated by age and sex, but how these factors influence baseline cardiac gene expression remains incompletely understood. Here, we used RNA sequencing and mass spectrometry to compare gene expression in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9e54685173a854f7bd369c1fad4546
https://doi.org/10.1152/ajpheart.00244.2022
https://doi.org/10.1152/ajpheart.00244.2022
The functions of proteins depend on their spatial and temporal distributions, which are not directly measured by static protein abundance. Under protein misfolding stress, the unfolded protein response (UPR) pathway remediates proteostasis in part by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d10edaaa8889cb9ce37fbb6c5f144b8
https://doi.org/10.1101/2023.01.04.521821
https://doi.org/10.1101/2023.01.04.521821
Autor:
Deborah M. Eaton, Remus M. Berretta, Jacqueline E. Lynch, Joshua G. Travers, Ryan D. Pfeiffer, Michelle L. Hulke, Huaqing Zhao, Alexander R. H. Hobby, Giana Schena, Jaslyn P. Johnson, Markus Wallner, Edward Lau, Maggie P. Y. Lam, Kathleen C. Woulfe, Nathan R. Tucker, Timothy A. McKinsey, Marla R. Wolfson, Steven R. Houser
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 323(4)
Approximately 50% of all heart failure (HF) diagnoses can be classified as HF with preserved ejection fraction (HFpEF). HFpEF is more prevalent in females compared with males, but the underlying mechanisms are unknown. We previously showed that press
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0533c0ec3093f75dbffdca87ff1e9495
https://pubmed.ncbi.nlm.nih.gov/36053749
https://pubmed.ncbi.nlm.nih.gov/36053749
Publikováno v:
Mol Omics
RNA and protein levels correlate only partially and some transcripts are better correlated with their protein counterparts than others. This suggests that in aging and disease studies, some transcriptomics markers may carry more information in predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6f27c63b42f8f9e359624daf9acdc3
https://doi.org/10.1039/d1mo00178g
https://doi.org/10.1039/d1mo00178g
The risks of heart diseases are significantly modulated by biological age and sex, but how these factors influence baseline cardiac gene expression remains incompletely understood. Here we characterized young adult and early aging mouse hearts using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b160d814cc1df18d84e795a8730da28
https://doi.org/10.1101/2022.05.11.491401
https://doi.org/10.1101/2022.05.11.491401