Natural Regulation of Immunity to Minor Histocompatibility Antigens

Autor: Emily Manktelow, Nathan J Robertson, Fazila Hashim, Julian Dyson, François A. Lemonnier, Diane Scott, Jian-Guo Chai, Maggie Millrain, Elizabeth Simpson

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2007, 178 (6), pp.3558-65. ⟨10.4049/jimmunol.178.6.3558⟩
Journal of Immunology, 2007, 178 (6), pp.3558-65. ⟨10.4049/jimmunol.178.6.3558⟩

MHC-matched hemopoietic stem cell transplantation is commonly used for the treatment of some forms of leukemia. Conditioning regimens before transplant act to reduce the burden of leukemic cells and the graft-vs-leukemia (GvL) effect can eliminate re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3622dc5793e525ea0a239640c4a7d74f
https://doi.org/10.4049/jimmunol.178.6.3558

TCR-α CDR3 Loop Audition Regulates Positive Selection

Autor: Elizabeth Simpson, Anna L. Furmanski, H. Robson MacDonald, Julian Dyson, Istvan Bartok, Maggie Millrain, Cristina Ferreira, R K Lees, Philippe Guillaume

Publikováno v: Scopus-Elsevier

How positive selection molds the T cell repertoire has been difficult to examine. In this study, we use TCR-β-transgenic mice in which MHC shapes TCR-α use. Differential AV segment use is directly related to the constraints placed on the compositio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbcdfe76e45781b2b1596ffad86b3dc
https://doi.org/10.4049/jimmunol.177.4.2477

HY peptides modulate transplantation responses to skin allografts

Autor: Elizabeth Simpson, Phillip Chandler, Jian-Guo Chai, Eddie A. James, Diane Scott, Maggie Millrain

Publikováno v: International immunology. 14(11)

Injection of female C57BL/6 mice with immature female bone marrow-derived dendritic cells (BMDC) pulsed with a single immunodominant HY(Db) Uty peptide, WMHHNMDLI, induces prolonged survival of syngeneic male skin grafts. In contrast, injection of im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3d8f6d520a41e649ff11bb4c8feaa9
https://pubmed.ncbi.nlm.nih.gov/12407024

Acceptance of skin grafts between mice bearing different allelic forms of beta 2-microglobulin

Autor: Phillip Chandler, Elizabeth Simpson, AN Antoniou, PJ Robinson, PJ Dyson, RA Hederer, Andrew L. Mellor, Maggie Millrain

Publikováno v: Transplantation. 61(2)

Single amino acid disparities in MHC class I molecules can elicit transplantation responses. Since beta 2 microglobulin (beta 2m) is noncovalently associated with class I antigens on the cell membrane we investigated whether the single amino acid pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46753618136a669b6bf21865f5e1f525
https://pubmed.ncbi.nlm.nih.gov/8600640

Role of immunoproteasomes in cross-presentation

Autor: Michael J. Palmowski, Maggie Millrain, Mariolina Salio, Julian Dyson, Edward James, Caroline Addey, Awen Gallimore, Elizabeth Simpson, Uzi Gileadi, Vincenzo Cerundolo, Diane Scott

Publikováno v: Scopus-Elsevier

The evidence that proteasomes are involved in the processing of cross-presented proteins is indirect and based on the in vitro use of proteasome inhibitors. It remains, therefore, unclear whether cross-presentation of MHC class I peptide epitopes can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3033e3a88ab8450a6ad65b30415b8502
http://www.scopus.com/inward/record.url?eid=2-s2.0-33745830160&partnerID=MN8TOARS