Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Maggie M. Calkins"'
Autor:
Jason Wallach, Andrew B. Cao, Maggie M. Calkins, Andrew J. Heim, Janelle K. Lanham, Emma M. Bonniwell, Joseph J. Hennessey, Hailey A. Bock, Emilie I. Anderson, Alexander M. Sherwood, Hamilton Morris, Robbin de Klein, Adam K. Klein, Bruna Cuccurazzu, James Gamrat, Tilka Fannana, Randy Zauhar, Adam L. Halberstadt, John D. McCorvy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Serotonergic psychedelics possess considerable therapeutic potential. Although 5-HT2A receptor activation mediates psychedelic effects, prototypical psychedelics activate both 5-HT2A-Gq/11 and β-arrestin2 transducers, making their respectiv
Externí odkaz:
https://doaj.org/article/30bf5d9d5f33452682a561177a856eb2
Autor:
Nicholas J. Malcolm, Barbara Palkovic, Daniel J. Sprague, Maggie M. Calkins, Janelle K. Lanham, Adam L. Halberstadt, Astrid G. Stucke, John D. McCorvy
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107121- (2023)
Summary: Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent and β-arre
Externí odkaz:
https://doaj.org/article/fc293bbf9b694c2ca0a05e1bba69bdbb
Autor:
Vern Lewis, Emma M. Bonniwell, Janelle K. Lanham, Abdi Ghaffari, Hooshmand Sheshbaradaran, Andrew B. Cao, Maggie M. Calkins, Mario Alberto Bautista-Carro, Emily Arsenault, Andre Telfer, Fatimeh-Frouh Taghavi-Abkuh, Nicholas J. Malcolm, Fatema El Sayegh, Alfonso Abizaid, Yasmin Schmid, Kathleen Morton, Adam L. Halberstadt, Argel Aguilar-Valles, John D. McCorvy
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112203- (2023)
Summary: Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) analog 2-bromo-LSD (2-Br-LSD) at more than 33 aminergic G protein-cou
Externí odkaz:
https://doaj.org/article/2c21b545191b4d11912819fd72041816
Autor:
Michael J. Cunningham, Hailey A. Bock, Inis C. Serrano, Benjamin Bechand, D. J. Vidyadhara, Emma M. Bonniwell, David Lankri, Priscilla Duggan, Antonina L. Nazarova, Andrew B. Cao, Maggie M. Calkins, Prashant Khirsariya, Christopher Hwu, Vsevolod Katritch, Sreeganga S. Chandra, John D. McCorvy, Dalibor Sames
Publikováno v:
ACS Chemical Neuroscience. 14:119-135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b9f93588a0f41fb42a8fed160f01c59
https://doi.org/10.1021/acschemneuro.2c00597
https://doi.org/10.1021/acschemneuro.2c00597
Autor:
Ahmed M. Elmansi, Nada H. Eisa, Sudharsan Periyasamy-Thandavan, Galina Kondrikova, Dmitry Kondrikov, Maggie M. Calkins, Alexandra Aguilar-Pérez, Jie Chen, Maribeth Johnson, Xing-ming Shi, Charles Reitman, Meghan E. McGee-Lawrence, Kyler S. Crawford, Michael B. Dwinell, Brian F. Volkman, Joe B. Blumer, Louis M. Luttrell, John D. McCorvy, William D. Hill
Publikováno v:
ACS Pharmacology & Translational Science. 6:22-39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7bea10d94ec42942c23db1f1c89ca93
https://doi.org/10.1021/acsptsci.2c00040
https://doi.org/10.1021/acsptsci.2c00040
Autor:
Andrew B. Kleist, Shawn Jenjak, Andrija Sente, Lauren J. Laskowski, Martyna Szpakowska, Maggie M. Calkins, Emilie I. Anderson, Lisa M. McNally, Raimond Heukers, Vladimir Bobkov, Francis C. Peterson, Monica A. Thomas, Andy Chevigné, Martine J. Smit, John D. McCorvy, M. Madan Babu, Brian F. Volkman
Publikováno v:
Kleist, A B, Jenjak, S, Sente, A, Laskowski, L J, Szpakowska, M, Calkins, M M, Anderson, E I, McNally, L M, Heukers, R, Bobkov, V, Peterson, F C, Thomas, M A, Chevigné, A, Smit, M J, McCorvy, J D, Babu, M M & Volkman, B F 2022, ' Conformational selection guides β-arrestin recruitment at a biased G protein–coupled receptor ', Science, vol. 377, no. 6602, pp. 222-228 . https://doi.org/10.1126/science.abj4922
Science
Science, 377(6602), 222-228. American Association for the Advancement of Science
Mol Cell
Science
Science, 377(6602), 222-228. American Association for the Advancement of Science
Mol Cell
G protein–coupled receptors (GPCRs) recruit β-arrestins to coordinate diverse cellular processes, but the structural dynamics driving this process are poorly understood. Atypical chemokine receptors (ACKRs) are intrinsically biased GPCRs that enga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f332ddb2bf54ac7f4866ac1e4d21fd39
https://research.vu.nl/en/publications/7f7010df-7f31-4109-8c52-e0d4b931570d
https://research.vu.nl/en/publications/7f7010df-7f31-4109-8c52-e0d4b931570d
