Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Maggie L. Bobbin"'
Autor:
Frank Seeliger, Jimmy A. Guo, Luca Pinello, Mohammad Bohlooly-Y, Roberto Nitsch, Lorenz M. Mayr, Shengdar Q. Tsai, Mick D. Fellows, Pinar Akcakaya, Marcello Maresca, Jose Malagon-Lopez, Alba Carreras, Mikael Bjursell, J. Keith Joung, Nhu T. Nguyen, Mike Firth, Sara P. Garcia, Kendell Clement, Martin J. Aryee, Michelle J. Porritt, Tania Baccega, Maggie L. Bobbin
Publikováno v:
Nature
CRISPR–Cas genome-editing nucleases hold substantial promise for developing human therapeutic applications1–6 but identifying unwanted off-target mutations is important for clinical translation7. A well-validated method that can reliably identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af450eb5d0a837ac895b4df97292f10b
http://europepmc.org/articles/PMC6194229
http://europepmc.org/articles/PMC6194229
Autor:
Luca Pinello, M. Kendell Clement, Mikael Bjursell, Michelle J. Porritt, Mohammad Bohlooly-Y, Lorenz M. Mayr, Tania Baccega, Jimmy A. Guo, Pinar Akcakaya, Martin J. Aryee, J. Keith Joung, Jose Malagon Lopez, Mick D. Fellows, Frank Seeliger, Maggie L. Bobbin, Marcello Maresca, Shengdar Q. Tsai, Roberto Nitsch, Nhu T. Nguyen, Alba Carreras, Mike Firth, Sara P. Garcia
CRISPR-Cas genome-editing nucleases hold substantial promise for human therapeutics1–5 but identifying unwanted off-target mutations remains an important requirement for clinical translation6, 7. For ex vivo therapeutic applications, previously pub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecbdcbc3134b6540f2cb620ed94cb75
https://doi.org/10.1101/272724
https://doi.org/10.1101/272724
Autor:
John J. Rossi, Maggie L. Bobbin
Publikováno v:
Annual review of pharmacology and toxicology. 56
A resurgence in clinical trials using RNA interference (RNAi) occurred in 2012. Although there were initial difficulties in achieving efficacious results with RNAi without toxic side effects, advances in delivery and improved chemistry made this resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16a618130756f80088a1fd8033eb05b
https://pubmed.ncbi.nlm.nih.gov/26738473
https://pubmed.ncbi.nlm.nih.gov/26738473
Publikováno v:
Genome Medicine
Genome medicine, vol 7, iss 1
Genome medicine, vol 7, iss 1
HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddf4bb9f502b7f6fa3dbe4024408dc9