Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Magee Thomas Victor"'
Autor:
Gang Xing, David Price, Aaron C. Smith, Jayasankar Jasti, Kentaro Futatsugi, Steven B. Coffey, Meihua Tu, Kevin D. Parris, Yan Weng, Dilinie P. Fernando, Kay Ahn, Matthew S. Dowling, Kim Huard, Jayvardhan Pandit, Jeffrey A. Pfefferkorn, Benjamin A. Thuma, Brian Raymer, Tim F. Ryder, Gregory J. Tesz, Andre Shavnya, Amit S. Kalgutkar, Jun Zhou, Hanna M. Wisniewska, Jemy A. Gutierrez, John D. Knafels, Magee Thomas Victor, Ingrid A. Stock, Sylvie Perez, Tsai Andy
Publikováno v:
Journal of medicinal chemistry. 63(22)
Increased fructose consumption and its subsequent metabolism have been implicated in metabolic disorders such as nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH) and insulin resistance. Ketohexokinase (KHK) converts fructose to fruct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c107a413095d612ee94dff2632747e3a
https://pubmed.ncbi.nlm.nih.gov/32910646
https://pubmed.ncbi.nlm.nih.gov/32910646
Autor:
Gabriele E. Sonnenberg, Collin Crowley, Trenton T. Ross, Michelle Clasquin, Arthur Bergman, Anu Nigam, Yan Weng, Derek M. Erion, Kou Kou, Morris J. Birnbaum, Gang Xing, Nicholas B. Vera, Kristin Chidsey, Veena Somayaji, William P. Esler, Jemy A. Gutierrez, Richard Allen, Kendra K. Bence, Jeffrey A. Pfefferkorn, Magee Thomas Victor, Sylvie Perez, Matt Blatnik, Gregory J. Tesz, Melissa A. Fulham, Wei Liu
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 48, Iss, Pp 101196-(2021)
Molecular Metabolism, Vol 48, Iss, Pp 101196-(2021)
Objective Recent studies suggest that excess dietary fructose contributes to metabolic dysfunction by promoting insulin resistance, de novo lipogenesis (DNL), and hepatic steatosis, thereby increasing the risk of obesity, type 2 diabetes (T2D), non-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9832276149b62b82c13f9550e053414
https://doi.org/10.1016/j.molmet.2021.101196
https://doi.org/10.1016/j.molmet.2021.101196
Autor:
John D. Knafels, David Price, Matthew Gorgoglione, Aaron C. Smith, Kevin D. Parris, Jemy A. Gutierrez, Magee Thomas Victor, Erik Alphie Lachapelle, Yan Weng, Edward L. Conn, Jeffrey A. Pfefferkorn, Jane M. Withka, Kim Huard, Matthew S. Dowling, Timothy A. Subashi, Trenton T. Ross, Benjamin A. Thuma, Kris A. Borzilleri, Paul A. Amor, Jeffrey S. Culp, Meihua Tu, Sylvie Perez, Jayvardhan Pandit, Andre Shavnya, Boris A. Chrunyk, Gang Xing, John D. Weaver, Yang Cong, Kay Ahn, David A. Beebe, Brian Raymer, Gregory J. Tesz, Steven B. Coffey
Publikováno v:
Journal of Medicinal Chemistry. 60:7835-7849
Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b654213309542f5b2a14a9d23ebc4df8
https://doi.org/10.1021/acs.jmedchem.7b00947
https://doi.org/10.1021/acs.jmedchem.7b00947
Autor:
Michael Herr, Daniel P. Canterbury, Derek M. Erion, Janice A. Brown, Mark Niosi, Bhagyashree Khunte, Matthew Gorgoglione, Jaclyn Siderewicz, Jana Polivkova, Carmen N. Garcia-Irizarry, Nathan E. Genung, Adam M. Gilbert, Justin I. Montgomery, Daniel P. Uccello, Timothy P. Rolph, Adhiraj Lanba, Qifang Li, Nicholas B. Vera, Kentaro Futatsugi, Gary Erik Aspnes, Zhenhong Li, James R. Gosset, Kim Huard, Matthew Merrill Hayward, Shawn Cabral, Magee Thomas Victor, Julie Purkal, Kevin B. Bahnck
Publikováno v:
Journal of Medicinal Chemistry. 59:1165-1175
Inhibition of the sodium-coupled citrate transporter (NaCT or SLC13A5) has been proposed as a new therapeutic approach for prevention and treatment of metabolic diseases. In a previous report, we discovered dicarboxylate 1a (PF-06649298) which inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b4cd858c5eae974c53ce91c3e64131
https://doi.org/10.1021/acs.jmedchem.5b01752
https://doi.org/10.1021/acs.jmedchem.5b01752
Autor:
Michael Herr, James R. Gosset, Steven B. Coffey, Jana Polivkova, Timothy A. Subashi, Kay Ahn, Philip A. Carpino, Magee Thomas Victor, Brandon Pabst, Kevin B. Bahnck, Kim Huard, Kou Kou, David Hepworth, Kyuha Lee, Gregory J. Tesz, Allyn T. Londregan, Csilla C. Jorgensen, Anu Nigam, Hao Sun, Christian Perreault, Bryan Goodwin, Qifang Li, Markus Boehm, George T. Tkalcevic
Publikováno v:
Journal of Medicinal Chemistry. 58:7164-7172
Inhibition of triacylglycerol (TAG) biosynthetic enzymes has been suggested as a promising strategy to treat insulin resistance, diabetes, dyslipidemia, and hepatic steatosis. Monoacylglycerol acyltransferase 3 (MGAT3) is an integral membrane enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff3cfbe5a414f8fbc55e9bc5c4d6884
https://doi.org/10.1021/acs.jmedchem.5b01008
https://doi.org/10.1021/acs.jmedchem.5b01008
Autor:
Melissa S. Harris, Veerabahu Shanmugasundaram, Jae-Hyun Cho, Parag Sahasrabudhe, Kris A. Borzilleri, Anil Rane, H. Heaslet, Alex McColl, Boris A. Chrunyk, Henry Putz, Mark Edward Flanagan, Arthur G. Palmer, Brian M. Lacey, Chakrapani Subramanyam, Tim Subashi, Kelly C. Fahnoe, Magee Thomas Victor, Ron Sarver, George A. Karam, J. Richard Miller, Jane M. Withka
Publikováno v:
Applied Biophysics for Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b21d628db86c53d3c2e4007bbc52d101
https://doi.org/10.1002/9781119099512.ch13
https://doi.org/10.1002/9781119099512.ch13
Autor:
Magee Thomas Victor, Thuy-Trinh Nguyen, Joseph A. Abramite, Yue Shen, Jian Lin, Jiri Aubrecht, Fadia Dib-Hajj, Jeremy T. Starr, Alita A. Miller, Matthew Frank Brown, Shawn H. MacVane, Michael D. Huband, Li Zhang, Karl Granskog, Bryan Li, Jinshan Michael Chen, James M. McKim, John P. O'Donnell, Karen L. Leach, Paul C. Wilga, David P. Nicolau, Sandra P. McCurdy, Mark Edward Flanagan, Antonia F. Stepan, Andrew P. Tomaras, Mark C. Noe, Michael Kuhn, Scott B. Seibel, Rebecca Irvine, Jinfeng Xu, David C. Ackley, David R. Luke, Jared L. Crandon, Joel R. Hardink, Andrew Butler
Publikováno v:
Journal of Medicinal Chemistry. 56:5079-5093
We report novel polymyxin analogues with improved antibacterial in vitro potency against polymyxin resistant recent clinical isolates of Acinetobacter baumannii and Pseudomonas aeruginosa . In addition, a human renal cell in vitro assay (hRPTEC) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e495f860c984ae946db4940511966812
https://doi.org/10.1021/jm400416u
https://doi.org/10.1021/jm400416u
Autor:
Kuang Tongtao, Wang Zhibo, Yuanqiang Long, Jian Li, Xin Ran, Jinshan Chen, David W. Piotrowski, Hua Yi, Cristiano Ruch Werneck Guimarães, Chonggang Liu, Frank Rong, Shai Li, Heather N. Frost, Guoyun Bai, Junwei Shen, Jieyang Tan, James Federico, Hua Yu, Kexin Xu, Li Chen, Liu Bo, Ai Chaowu, Yingfu Li, Chen Yuanwei, Zhilong Jiang, Geng Xi, Hongyun Qiao, Carrie Whitney-Pickett, Magee Thomas Victor, Bo Shan, Kai Wu, Matthew D. Troutman, Mark C. Noe, Dale Gordon Mcleod, Youpei Chen, Jing Du, Gilles H. Goetz, Dapeng Zhao, Qiu Gao, Li Xiaoyong, Changqing Shi
Publikováno v:
Tetrahedron Letters. 54:3298-3301
We report novel syntheses of 12-membered macrocyclic templates and a library of 4000 macrocyclic analogs. The key macrocyclization step was performed at up to 100 g scale without resorting to syringe pumps, flow reactors or large volumes of solvent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54e188654e519db141ac2ddc51f9b94f
https://doi.org/10.1016/j.tetlet.2013.04.058
https://doi.org/10.1016/j.tetlet.2013.04.058
Autor:
Veerabahu Shanmugasundaram, Michael D. Huband, Jinshan Michael Chen, Thuy-Trinh Nguyen, Eric S. Marr, Karl Granskog, Bruce A. Maguire, Sandra P. McCurdy, Timothy A. Subashi, Seungil Han, Magee Thomas Victor
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1727-1731
A novel series of 3- O -carbamoyl erythromycin A derived analogs, labeled carbamolides, with activity versus resistant bacterial isolates of staphylococci (including macrolide and oxazolidinone resistant strains) and streptococci are reported. An ( R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1948e2c64bd3302a83b2649d49e83180
https://doi.org/10.1016/j.bmcl.2013.01.067
https://doi.org/10.1016/j.bmcl.2013.01.067
Autor:
Inish O'Doherty, Brandon Pabst, Adam M. Gilbert, Kimberly F. Fennell, Chris Limberakis, Jinshan Chen, Jayvardhan Pandit, Matthew Frank Brown, Markus Boehm, Rushi Patel, Jeffrey A. Pfefferkorn, Jemy A. Gutierrez, Robert M. Oliver, Jiangli Yan, Jeremy T. Starr, Kay Ahn, Brandon P. Schuff, Amit S. Kalgutkar, Kieran F. Geoghegan, Kevin D. Parris, Veerabahu Shanmugasundaram, Cecile Vernochet, Timothy P. Rolph, Ye Che, Nicholas B. Vera, Alison H. Varghese, Adhiraj Lanba, Magee Thomas Victor, Jessica Calloway
Publikováno v:
ACS chemical biology. 11(9)
Lysophospholipase-like 1 (LYPLAL1) is an uncharacterized metabolic serine hydrolase. Human genome-wide association studies link variants of the gene encoding this enzyme to fat distribution, waist-to-hip ratio, and nonalcoholic fatty liver disease. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8faf739c4bd62a7e0dc07d74faa9aee9
https://pubmed.ncbi.nlm.nih.gov/27391855
https://pubmed.ncbi.nlm.nih.gov/27391855