Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Maged Zeineldin"'
Autor:
Tiane Chen, Maged Zeineldin, Blake A. Johnson, Yi Dong, Akshay Narkar, Taibo Li, Jin Zhu, Rong Li, Tatianna C. Larman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 5, Pp 488-501 (2021)
Although much is known about the gene mutations required to drive colorectal cancer (CRC) initiation, the tissue-specific selective microenvironments in which neoplasia arises remains less characterized. Here, we determined whether modulation of inte
Externí odkaz:
https://doaj.org/article/2c3385a9b6cd4a049c1bce90c34c17fd
Autor:
Maged Zeineldin, Sara Federico, Xiang Chen, Yiping Fan, Beisi Xu, Elizabeth Stewart, Xin Zhou, Jongrye Jeon, Lyra Griffiths, Rosa Nguyen, Jackie Norrie, John Easton, Heather Mulder, Donald Yergeau, Yanling Liu, Jianrong Wu, Collin Van Ryn, Arlene Naranjo, Michael D. Hogarty, Marcin M. Kamiński, Marc Valentine, Shondra M. Pruett-Miller, Alberto Pappo, Jinghui Zhang, Michael R. Clay, Armita Bahrami, Peter Vogel, Seungjae Lee, Anang Shelat, Jay F. Sarthy, Michael P. Meers, Rani E. George, Elaine R. Mardis, Richard K. Wilson, Steven Henikoff, James R. Downing, Michael A. Dyer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.
Externí odkaz:
https://doaj.org/article/08a87c1bf95d4f798e9e0d5a7daabd61
Autor:
Maged Zeineldin, Kristi Neufeld
Publikováno v:
Bio-Protocol, Vol 2, Iss 22 (2012)
The gastrointestinal (GI) tract is lined by a single layer of epithelial cells which function in secretion, absorption, and digestion. In addition, most GI tract tumors develop from epithelial cells (carcinomas). This protocol describes isolation of
Externí odkaz:
https://doaj.org/article/57c0e452f2b34ab997bdc59e22af3e02
Autor:
Maged Zeineldin, Tatianna C. Larman
Publikováno v:
bioRxiv
Epithelial metaplasia is a common adaptation to chronic inflammatory processes and can be associated with increased risk of dysplasia and cancer. The distal colon of patients with inflammatory bowel disease (IBD) commonly shows crypt architectural di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caebfa3c8fc627aae6352501222df176
https://doi.org/10.1101/2023.02.01.526729
https://doi.org/10.1101/2023.02.01.526729
Autor:
Blake A. Johnson, Taibo Li, Tatianna Larman, Yi Dong, Tiane Chen, Jin Zhu, Akshay Narkar, Maged Zeineldin, Rong Li
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 5, Pp 488-501 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 5, Pp 488-501 (2021)
Although much is known about the gene mutations required to drive colorectal cancer (CRC) initiation, the tissue-specific selective microenvironments in which neoplasia arises remains less characterized. Here, we determined whether modulation of inte
Publikováno v:
Cancer Research. 82:B026-B026
Epithelial metaplasia, or the histologically evident replacement of one differentiated somatic cell type with another, offers insights into mucosal homeostasis as an adaptation to diverse inflammatory pathogenic stimuli. The cellular framework for me
Publikováno v:
Neuron. 110(18)
Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage contributes to neuroblastoma formation. The developmental arrest of these c
Autor:
Heather L. Mulder, Peter Vogel, Steven Henikoff, Marcin Kamiński, Richard K. Wilson, Jinghui Zhang, Anang A. Shelat, James R. Downing, Marc Valentine, Yanling Liu, Xin Zhou, Yiping Fan, Armita Bahrami, Arlene Naranjo, Collin Van Ryn, Rani E. George, Sara M. Federico, Beisi Xu, Jongrye Jeon, Seungjae Lee, Xiang Chen, Elizabeth Stewart, John Easton, Donald Yergeau, Shondra M. Pruett-Miller, Jay F. Sarthy, Michael P. Meers, Maged Zeineldin, Michael A. Dyer, Lyra Griffiths, Michael R. Clay, Jackie L. Norrie, Elaine R. Mardis, Rosa Nguyen, Alberto S. Pappo, Michael D. Hogarty, Jianrong Wu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correlate
Autor:
Christie B. Nguyen, Mary Fowkes, Anqi Ma, Zulekha A. Qadeer, Zhen Sun, Emily Bernstein, David Meni, April Cook, Armita Bahrami, Aroa Soriano, Jian Jin, Asif Chowdhury, Xiang Chen, Fumiko Dekio, Miguel F. Segura, Elizabeth Stewart, Sara M. Federico, Orla Deevy, Stephen S. Roberts, Maged Zeineldin, Luz Jubierre, Michael A. Dyer, Dan Filipescu, Soledad Gallego, William A. Weiss, Nai-Kong V. Cheung, Lyra Griffiths, David Valle-Garcia, Dan Hasson, John M. Maris, David B. Finkelstein
Publikováno v:
Cancer Cell
ATRX alterations occur at high frequency in neuroblastoma of adolescents and young adults. Particularly intriguing are the large N-terminal deletions of ATRX (Alpha Thalassemia/Mental Retardation, X-linked) that generate in-frame fusion (IFF) protein
Autor:
Seungjae Lee, Elizabeth Stewart, James R. Downing, Armita Bahrami, Heather L. Mulder, Marc Valentine, Jianrong Wu, Rani E. George, Donald Yergeau, Michael D. Hogarty, Maged Zeineldin, Elaine R. Mardis, Xin Zhou, Sara M. Federico, Beisi Xu, Anang A. Shelat, Richard K. Wilson, Yanling Liu, Jinghui Zhang, Jongrye Jeon, Arlene Naranjo, Shondra M. Pruett-Miller, John Easton, Michael R. Clay, Collin Van Ryn, Lyra Griffiths, Xiang Chen, Yiping Fan, Marcin Kamiński, Alberto S. Pappo, Michael A. Dyer
SUMMARYAggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9c9691bc389d4e691e3cbd0c5b70af
https://doi.org/10.1101/379636
https://doi.org/10.1101/379636