Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Magdy M. Gineinah"'
1
Akademický článek
Design, synthesis, molecular docking, and molecular dynamic studies of novel quinazoline derivatives as phosphodiesterase 7 inhibitors
Autor: Afaf A. El-Malah, Magdy M. Gineinah, Maan T. Khayat, Anfal S. Aljahdali, Marwa M. Safar, Hadeel A. Almazmumi, Roaa M. Khinkar
Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Phosphodiesterase 7 (PDE7) is a high-affinity cyclic AMP (cAMP)-specific PDE that is expressed in immune and proinflammatory cells. In this work, we explore the possibility that selective small molecule inhibitors of this enzyme family
Externí odkaz: https://doaj.org/article/217017829d4d45538e0140485c4c4db3
Zobrazit plný text záznamu
2
Akademický článek
Selective COX-2 Inhibitors: Road from Success to Controversy and the Quest for Repurposing
Autor: Afaf A. El-Malah, Magdy M. Gineinah, Pran Kishore Deb, Ahdab N. Khayyat, Monika Bansal, Katharigatta N. Venugopala, Anfal S. Aljahdali
Publikováno v: Pharmaceuticals, Vol 15, Iss 7, p 827 (2022)
The introduction of selective COX-2 inhibitors (so-called ‘coxibs’) has demonstrated tremendous commercial success due to their claimed lower potential of serious gastrointestinal adverse effects than traditional NSAIDs. However, following the re
Externí odkaz: https://doaj.org/article/8c7629413e8f42de88fed1fd3dfed592
Zobrazit plný text záznamu
3
Synthesis, biological screening, and molecular docking of quinazolinone and quinazolinethione as phosphodiesterase 7 inhibitors
Autor: Magdy M Gineinah, Nesreen S. Ahmed, Sherin M Elfeky, Tariq R. Sobahi
Publikováno v: Archiv der PharmazieREFERENCES. 353(1)
N-Substituted isatoic anhydrides were used as starting materials for the synthesis of compounds 5-16 through alkali hydrolysis, Schiff base reactions, and oxidation. Compounds 18-23 were obtained by thionation of their oxo isosteres using Lawesson's
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741081f2a6c73b4f93f741eb858288a7
https://pubmed.ncbi.nlm.nih.gov/31696968
Zobrazit plný text záznamu
4
Ultrasound one pot synthesis of fused quinazolinones and quinazolinediones, screening and molecular docking study as phosphodiesterase 7A inhibitors
Autor: Nesreen S. Ahmed, Tariq R. Sobahi, Sherin M Elfeky, Magdy M Gineinah
Publikováno v: Egyptian Journal of Chemistry.
Phosphodiesterase 7A enzyme is one the most recent targets for designing potent anti-inflammatory agents with minimal side effects. Quinazolinones are unique building blocks of wide biological activities. Different Quinazolinones were reported to act
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8766054b9d36dcb7cfa46b6bc6a6de8c
https://doi.org/10.21608/ejchem.2019.7130.1587
Zobrazit plný text záznamu
5
Synthesis and antitumor activity of new pyrido[2,3-d]pyrimidine derivatives
Autor: Walaa M. El-Husseiny, Sahar M. I. Badr, Magda N. A. Nasr, Magdy M. Gineinah
Publikováno v: Medicinal Chemistry Research. 22:3943-3952
New series of pyrido[2,3-d]pyrimidines such as; 5-(4-aryl-5-sulfanyl-4H-[1,2,4]triazol-3-yl) 1H,3H,8H-pyrido[2,3-d]pyrimidine-2,4,7-triones 6, 7; S-[3-(2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)-4-(4-substituted phenyl)-4H-[1,2,4]
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::600e0c6d64cfa417d7553b6af1dfb025
https://doi.org/10.1007/s00044-012-0396-0
Zobrazit plný text záznamu
6
6-, 7- AND 8-(5-ARY L-1-PHENYL-2-PYRAZOLIN-3-LY)IMIDAZO- AND PYRIMIDO[2,1-b]BENZOTHIAZOLES AS NOVEL ANTICONVULSANT AGENTS
Autor: Magdy M. Gineinah
Publikováno v: Scientia Pharmaceutica
Volume 69
Issue 1
Pages 53-61
Pages 52-60
Some new derivatives of 2-amino-5- and 6-(5-aryl-1-phenyl-2-pyrazolin-3-yl)benzothiazole were synthesized from the corresponding aminophenyl compounds by reaction with KSCN/Br2 to build up the benzothiazole ring. The aminophenyl derivatives of pyrazo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ded12098f09e1d40fd46d305277b9ea
https://doi.org/10.3797/scipharm.aut-01-06
Zobrazit plný text záznamu
9
ChemInform Abstract: Pyrido[2,3-d]pyrimidines and Pyrimido[5′,4′:5,6]pyrido[2,3-d]pyrimidines as New Antiviral Agents: Synthesis and Biological Activity
Autor: Magda N. A. Nasr, Magdy M. Gineinah
Publikováno v: ChemInform. 33
A series of 7-amino- and 7-oxo-5-aryl-6-cyanopyrido[2, 3-d]pyrimidines, 4 and 11, respectively, and pyrimido [5', 4':5, 6]pyrido[2, 3-d]pyrimidine derivatives 6 and 7 was synthesized and investigated as antiviral agents. Different synthetic strategie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf452a31071dde183f4950709c97d80b
https://doi.org/10.1002/chin.200250118
Zobrazit plný text záznamu
10
Mesoionic 1,2,4-triazolo[4,3-c]quinazolines
Autor: Abd M. Ismaiel, Mohamed M. El-Kerdawy, Richard A. Glennon, Magdy M. Gineinah
Publikováno v: Journal of Heterocyclic Chemistry. 27:723-726
Because of the close structural similarity between triazoloquinazolines and certain 5-membered ring mesoionic heterocycles, all of which possess antiinflammatory activity, we prepared several examples of the novel mesoionic 1,2,4-triazolo[4,3-c]quina
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::485156f08aeec79219e9602ada3a6e16
https://doi.org/10.1002/jhet.5570270346
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje