Skeletal Muscle Atrophy Induced by Diabetes Is Mediated by Non-Selective Channels and Prevented by Boldine

Autor: Luis A. Cea, Walter Vásquez, Romina Hernández-Salinas, Alejandra Z. Vielma, Mario Castillo-Ruiz, Victoria Velarde, Magdiel Salgado, Juan C. Sáez

Publikováno v: Biomolecules, Vol 13, Iss 4, p 708 (2023)

Individuals with diabetes mellitus present a skeletal muscle myopathy characterized by atrophy. However, the mechanism underlying this muscular alteration remains elusive, which makes it difficult to design a rational treatment that could avoid the n

Externí odkaz: https://doaj.org/article/9e39fb2e13d94391a179a6bf37f6ca23

When a Little Bit More Makes the Difference: Expression Levels of GKRP Determines the Subcellular Localization of GK in Tanycytes

Autor: Magdiel Salgado, Patricio Ordenes, Marcos Villagra, Elena Uribe, María de los Angeles García-Robles, Estefanía Tarifeño-Saldivia

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

Glucose homeostasis is performed by specialized cells types that detect and respond to changes in systemic glucose concentration. Hepatocytes, β-cells and hypothalamic tanycytes are part of the glucosensor cell types, which express several proteins

Externí odkaz: https://doaj.org/article/238bcbe0358940119fc79e9d71c1c642

Dynamic localization of glucokinase and its regulatory protein in hypothalamic tanycytes.

Autor: Magdiel Salgado, Estefanía Tarifeño-Saldivia, Patricio Ordenes, Carola Millán, María José Yañez, Paula Llanos, Marcos Villagra, Roberto Elizondo-Vega, Fernando Martínez, Francisco Nualart, Elena Uribe, María de Los Angeles García-Robles

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94035 (2014)

Glucokinase (GK), the hexokinase involved in glucose sensing in pancreatic β cells, is also expressed in hypothalamic tanycytes, which cover the ventricular walls of the basal hypothalamus and are implicated in an indirect control of neuronal activi

Externí odkaz: https://doaj.org/article/c4135376954c46f084aeda67e5ad742d

Lactate activates hypothalamic POMC neurons by intercellular signaling

Autor: Magdiel Salgado, María De Los Ángeles García-Robles, Patricio Ordenes, Estefanía Tarifeño-Saldivia, Ricardo C. Araneda, Pablo S. Villar, Roberto Elizondo-Vega

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Previous studies indicate that the activity of hypothalamic POMC neurons can be regulated by glucose via intracellular mechanisms, but its regulation by lactate is poorly understood. In addition to its energetic role, lactate acts as a signaling mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c0b0c861c573b89f7bdb0522526e0e
https://pubmed.ncbi.nlm.nih.gov/34737351

Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior

Autor: Fernando J. Sepúlveda, María De Los Ángeles García-Robles, Magdiel Salgado, Roberto Elizondo-Vega, Patricio Ordenes, Carola Millán, Elena Uribe, María José Barahona, Romina María Uranga, Antonia Recabal, Fernando Martínez

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V). Several lines of evidence suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0240b18508b0e9ecd42b5599a2a7e3
https://doaj.org/article/462393bf23864745b7aa4f27a3d1fc85