Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Magdalene K. Sgagias"'
Publikováno v:
Journal of Biological Chemistry. 294:8309
Publikováno v:
Journal of Biomedical Science. 12:999-1011
Chemotherapy has been used for treatment of breast cancer but with limited success. We characterized the effects of bcl-2 antisense and cisplatin combination therapy in two human isogenic breast carcinoma cells p53(+)MCF-7 and p53(-)MCF-7/E6. The tra
Autor:
Min Kim, Kwangmoon Lee, Robert L. Kortum, Ying Yan, Magdalene K. Sgagias, Scott M. Stoeger, Robert E. Lewis, Kenneth H. Cowan
Publikováno v:
Cancer Research. 65:3986-3992
Kinase suppressor of Ras1 (KSR1) interacts with several mitogen-activated protein (MAP) kinase pathway components, including Raf, MAP/extracellular signal–regulated kinase (ERK) kinase (MEK), and ERK, and acts as a positive regulator of the Ras sig
Publikováno v:
Journal of Biological Chemistry. 277:33422-33430
Mutation in the BRCA1 gene is associated with an increased risk of breast and ovarian cancer. Recent studies have shown that the BRCA1 gene product may be important in mediating responses to DNA damage and genomic instability. Previous studies have i
Autor:
Gilbert H. Smith, Magdalene K. Sgagias, Ma Linda D. Henry, Corinne A. Boulanger, Lothar Hennighausen, Kay Uwe Wagner
Publikováno v:
Development. 129:1377-1386
Mammary gland biologists have long assumed that differentiated secretory epithelial cells undergo programmed cell death at the end of lactation and that the alveolar compartment is reconstituted from undifferentiated precursor cells in subsequent pre
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 11:177-185
This study was designed to determine whether in vitro exposure of isolated short-term human primary and metastatic breast tumor cell cultures to interferon-gamma (IFN-gamma) could enhance expression of the breast tumor associated DF3 antigen in assoc
Publikováno v:
Journal of Immunotherapy. 17:88-97
The effort to develop cell lines from surgical specimens has been a difficult goal for years. We derived short-term primary human mammary carcinoma cell lines from breast tumors in 20 of 23 patients. Morphologically, cultured cells showed small cells
Publikováno v:
Molecular Endocrinology. 5:1740-1747
We studied the effects of interleukin-1 alpha (IL-1) and tumor necrosis factor-alpha (TNF), alone and in combination, on MCF-7 breast cancer cells to determine whether these cytokines alter cell growth, TNF gene expression, and TNF secretion. We foun
Autor:
H. Shelton Earp, Karen E. Strunk, Rebecca S. Muraoka-Cook, Wesley McCall, Kenneth H. Cowan, Magdalene K. Sgagias, Melissa Sandahl, Laura S. Caskey, Debra Hunter, Carty Husted, Carolyn I. Sartor, William A. Rearick
Publikováno v:
Molecular and cellular biology. 26(17)
HER4 expression in human breast cancers correlates with a positive prognosis. While heregulin inhibits the growth of HER4-positive breast cancer cells, it does so by undefined mechanisms. We demonstrate that heregulin-induced HER4 activity inhibits c
Autor:
Kenneth H. Cowan, Magdalene K. Sgagias, Brad Hamik, Rebecca S. Spieker, Kay Uwe Wagner, L. Julie Huber, Lewis A. Chodosh, Scott M. Stoeger
Publikováno v:
Cell cycle (Georgetown, Tex.). 3(11)
In this report we describe the isolation of an isogenic pair of Brca1(++) and Brca1(-/-) murine mammary epithelial cells (MMECs). These cells were isolated from Brca1 conditional knock out mice which contained loxP sites flanking exon 11 of the Brca1