Co-grafts of Human Embryonic Stem Cell Derived Retina Organoids and Retinal Pigment Epithelium for Retinal Reconstruction in Immunodeficient Retinal Degenerate Royal College of Surgeons Rats

Autor: Biju B. Thomas, Bin Lin, Juan Carlos Martinez-Camarillo, Danhong Zhu, Bryce T. McLelland, Gabriel Nistor, Hans S. Keirstead, Mark S. Humayun, Magdalene J. Seiler

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

End-stage age-related macular degeneration (AMD) and retinitis pigmentosa (RP) are two major retinal degenerative (RD) conditions that result in irreversible vision loss. Permanent eye damage can also occur in battlefields or due to accidents. This s

Externí odkaz: https://doaj.org/article/e376a8ebe9c5472c8dce364154ef862d

Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models

Autor: Tai-Chi Lin, Magdalene J. Seiler, Danhong Zhu, Paulo Falabella, David R. Hinton, Dennis O. Clegg, Mark S. Humayun, Biju B. Thomas

Publikováno v: Stem Cells International, Vol 2017 (2017)

Dysfunction and death of retinal pigment epithelium (RPE) and or photoreceptors can lead to irreversible vision loss. The eye represents an ideal microenvironment for stem cell-based therapy. It is considered an “immune privileged” site, and the

Externí odkaz: https://doaj.org/article/0d5220df4138464a850e8e9a8a488293

Development of a protocol for maintaining viability while shipping organoid‐derived retinal tissue

Autor: Igor O. Nasonkin, Paige A. Winkler, Randolph D. Glickman, Ratnesh K. Singh, Francois Binette, Simon M. Petersen-Jones, Magdalene J. Seiler

Publikováno v: J Tissue Eng Regen Med

Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications. The high similarity of organoid-derived retinal tissue and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b006c3fdaa7e3f190904bdbca61474
https://doi.org/10.1002/term.2997

Tissue Engineering Strategies for Retina Regeneration

Autor: Mark S. Humayun, Kahini H. Patel, Magdalene J. Seiler, Deepthi S. Rajendran Nair, Vinoy Thomas, Juan Carlos Martinez Camarillo, Biju B. Thomas

Publikováno v: Applied Sciences, Vol 11, Iss 2154, p 2154 (2021)
Applied Sciences (Switzerland), vol 11, iss 5
Applied sciences (Basel, Switzerland), vol 11, iss 5

The retina is a complex and fragile photosensitive part of the central nervous system which is prone to degenerative diseases leading to permanent vision loss. No proven treatment strategies exist to treat or reverse the degenerative conditions. Rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63334619bddeda08d1420c92818c680f
https://www.mdpi.com/2076-3417/11/5/2154

Detailed Visual Cortical Responses Generated by Retinal Sheet Transplants in Rats with Severe Retinal Degeneration

Autor: David C. Lyon, Georgina A. Lean, Magdalene J. Seiler, Andrzej T. Foik, Bryce T McLelland, Robert B. Aramant, Leo R. Scholl, Anuradha Mathur

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 38, iss 50
Frontiers in Neuroscience

To combat retinal degeneration, healthy fetal retinal sheets have been successfully transplanted into both rodent models and humans, with synaptic connectivity between transplant and degenerated host retina having been confirmed. In rodent studies, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d690ffe7abaf8623d893c60d01221037
https://doi.org/10.1523/jneurosci.1279-18.2018