Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Magdalena Zernicka-Goetz"'
Autor:
Joachim De Jonghe, Tomasz S. Kaminski, David B. Morse, Marcin Tabaka, Anna L. Ellermann, Timo N. Kohler, Gianluca Amadei, Charlotte E. Handford, Gregory M. Findlay, Magdalena Zernicka-Goetz, Sarah A. Teichmann, Florian Hollfelder
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Droplet microfluidic methods have massively increased the throughput of single-cell sequencing campaigns. The benefit of scale-up is, however, accompanied by increased background noise when processing challenging samples and the overall RNA
Externí odkaz:
https://doaj.org/article/2dff37ca2c9b446281d0fc46cf2e490a
Autor:
Binyamin Duethorn, Fabian Groll, Bettina Rieger, Hannes C. A. Drexler, Heike Brinkmann, Ludmila Kremer, Martin Stehling, Marie-Theres Borowski, Karina Mildner, Dagmar Zeuschner, Magdalena Zernicka-Goetz, Marc P. Stemmler, Karin B. Busch, Juan M. Vaquerizas, Ivan Bedzhov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
How pluripotency transcription factors regulate the cellular architecture and energetics has remained largely unknown. Here the authors identify Lima1 as a key effector that mediates the pluripotency control of membrane dynamics and cellular metaboli
Externí odkaz:
https://doaj.org/article/ec59b98c93f041c9b516251c4f4d904c
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Polarization of the mammalian embryo at the right developmental time is critical for its development to term and would be valuable in assessing the potential of human embryos. However, tracking polarization requires invasive fluorescence sta
Externí odkaz:
https://doaj.org/article/042f8f73edd9486bb39078694f3aee34
Autor:
Berna Sozen, Victoria Jorgensen, Bailey A. T. Weatherbee, Sisi Chen, Meng Zhu, Magdalena Zernicka-Goetz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Human early development remains largely inaccessible, owing to technical and ethical limitations of working with natural embryos. Here the authors assess the extent to which human expanded pluripotent stem cells can specify distinct cell lineages and
Externí odkaz:
https://doaj.org/article/61641a4f11414d829e6fb891fdcf2245
Autor:
Matteo A. Molè, Tim H. H. Coorens, Marta N. Shahbazi, Antonia Weberling, Bailey A. T. Weatherbee, Carlos W. Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Single cell analysis of early human embryos identifies key changes in pluripotency, the requirement of FGF signalling for embryo survival, and defines a putative anterior-like region of hypoblast cells, providing insights into how early human develop
Externí odkaz:
https://doaj.org/article/d05c168f6b314658b4ceb906295bcd8b
Autor:
Marta N. Shahbazi, Tianren Wang, Xin Tao, Bailey A. T. Weatherbee, Li Sun, Yiping Zhan, Laura Keller, Gary D. Smith, Antonio Pellicer, Richard T. Scott, Emre Seli, Magdalena Zernicka-Goetz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Aneuploidy, abnormal chromosome number, is a major cause of early pregnancy loss. Here the authors determine the extent of post-implantation development of human embryos with common aneuploidies in culture, finding developmental arrest of monosomy 21
Externí odkaz:
https://doaj.org/article/f7ed59a03a7948919b6f685226479c9b
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The mechanisms behind the plasticity of embryos and how they deal with aneuploid cells are unclear. Here, the authors show that aneuploid cells in a mouse embryo are preferentially eliminated during pre- and peri-implantation development in a p53-dep
Externí odkaz:
https://doaj.org/article/581a6aee0696437ca64ad121b80a3b63
Autor:
Chris F. Graham, Shane Windsor, Anna Ajduk, Thanh Trinh, Anna Vincent, Celine Jones, Kevin Coward, Dilraj Kalsi, Magdalena Zernicka-Goetz, Karl Swann, Adrian L. R. Thomas
Publikováno v:
Biology Open, Vol 10, Iss 12 (2021)
Mouse zygote morphokinetics were measured during interphase, the mitotic period, cytokinesis, and two-cell stage. Sequences of rounder–distorted–rounder shapes were revealed, as were changing patterns of cross section area. A calcium chelator and
Externí odkaz:
https://doaj.org/article/a9f678e82e85446ea82279f515fcf8b2
Autor:
Thomas M Rawlings, Komal Makwana, Deborah M Taylor, Matteo A Molè, Katherine J Fishwick, Maria Tryfonos, Joshua Odendaal, Amelia Hawkes, Magdalena Zernicka-Goetz, Geraldine M Hartshorne, Jan J Brosens, Emma S Lucas
Publikováno v:
eLife, Vol 10 (2021)
Decidual remodelling of midluteal endometrium leads to a short implantation window after which the uterine mucosa either breaks down or is transformed into a robust matrix that accommodates the placenta throughout pregnancy. To gain insights into the
Externí odkaz:
https://doaj.org/article/c6eb93a51cf149c9a1d9e132f792a02e
Autor:
Kirsty ML Mackinlay, Bailey AT Weatherbee, Viviane Souza Rosa, Charlotte E Handford, George Hudson, Tim Coorens, Lygia V Pereira, Sam Behjati, Ludovic Vallier, Marta N Shahbazi, Magdalena Zernicka-Goetz
Publikováno v:
eLife, Vol 10 (2021)
Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of relevant stem cell model
Externí odkaz:
https://doaj.org/article/d46d1d36a49c41069f7d0163bcdf9464