Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Magdalena Sieprawska-Lupa"'
Autor:
Iain Anderson, Luke E Ulrich, Boguslaw Lupa, Dwi Susanti, Iris Porat, Sean D Hooper, Athanasios Lykidis, Magdalena Sieprawska-Lupa, Lakshmi Dharmarajan, Eugene Goltsman, Alla Lapidus, Elizabeth Saunders, Cliff Han, Miriam Land, Susan Lucas, Biswarup Mukhopadhyay, William B Whitman, Carl Woese, James Bristow, Nikos Kyrpides
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5797 (2009)
BACKGROUND:Methanomicrobiales is the least studied order of methanogens. While these organisms appear to be more closely related to the Methanosarcinales in ribosomal-based phylogenetic analyses, they are metabolically more similar to Class I methano
Externí odkaz:
https://doaj.org/article/630d89255bee4d5ab985f0e6c3751d9b
Autor:
Oleksandr Levenets, Anna Bartosik, Marta Sowińska, Karol Zuchowicz, Sujit Sasmal, Klara Korta-Piątek, Adam Radzimierski, Paulina Niedziejko, Oleksandr Popika, Mateusz Świrski, Agata Stachowicz, Maciej Mikulski, Magdalena Sieprawska-Lupa, Katarzyna Banaszak, Kinga Michalik, Kamil Kuś, Monika Madej, Adrian Podkowa, Karolina Gluza, Grzegorz Satała, Ewelina Cieluch, Dobrosława Krzemień, Andrzej Gondela, Grzegorz Ćwiertnia, Marek Wronowski, Nicolas Boutard, Aleksandra Więckowska, Joanna Zezula, Justyna Jabłońska, Mirosława Gładysz, Igor Tomczyk, Jacek Faber, Marcin Serocki, Eliza Drwal, Kamila Kozłowska-Tomczyk, Marta Skoda, Martin Swarbrick, Krzysztof Brzózka, Mateusz Nowak
Publikováno v:
Cancer Research. 82:1806-1806
Targeting PRMT5 in MTAP-deleted tumors in a synthetic lethal approach represents a promising antitumor strategy across many tumor types. Metabolic gene MTAP is localized at the 9p21 chromosome in the close proximity to CDKN2A tumor-suppressor locus.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08f276f2b9f1991124155b5824fbe3fb
https://doi.org/10.1158/1538-7445.am2022-1806
https://doi.org/10.1158/1538-7445.am2022-1806
Autor:
Nicolas Boutard, Arkadiusz Białas, Aleksandra Sabiniarz, Paweł Guzik, Katarzyna Banaszak, Artur Biela, Marcin Bień, Anna Buda, Barbara Bugaj, Ewelina Cieluch, Anna Cierpich, Łukasz Dudek, Hans-Michael Eggenweiler, Joanna Fogt, Monika Gaik, Andrzej Gondela, Krzysztof Jakubiec, Mirek Jurzak, Agata Kitlińska, Piotr Kowalczyk, Maciej Kujawa, Katarzyna Kwiecińska, Marcin Leś, Ralph Lindemann, Monika Maciuszek, Maciej Mikulski, Paulina Niedziejko, Alicja Obara, Henryk Pawlik, Tomasz Rzymski, Magdalena Sieprawska-Lupa, Marta Sowińska, Joanna Szeremeta-Spisak, Agata Stachowicz, Mateusz M. Tomczyk, Katarzyna Wiklik, Łukasz Włoszczak, Sylwia Ziemiańska, Adrian Zarębski, Krzysztof Brzózka, Mateusz Nowak, Charles-Henry Fabritius
In oncology, the "Warburg effect" describes the elevated production of energy by glycolysis in cancer cells. The ubiquitous and hypoxia-induced 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) plays a noteworthy role in the regulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef37f4c1c80edce81f72f55d3f7931e
https://ruj.uj.edu.pl/xmlui/handle/item/252764
https://ruj.uj.edu.pl/xmlui/handle/item/252764
Autor:
Marta Olszak-Płachta, Mateusz Nowak, Hugh Chapman, Magdalena Sieprawska-Lupa, Raymond Horvath, Klaudia Stefańska, Maciej Mikulski, Marcin Król, Katja Kuokkanen, Michal Galezowski, Mariusz Galek, Niina Jalava, Justyna Adamczyk, Joanna Szeremeta-Spisak, Ullamari Pesonen, Josef Messinger, Harri Salo, Radosław Obuchowicz, Charles-Henry Fabritius, Anna Buda, Peteris Prusis, Timo Korjamo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2610-2615
A series of 1-Sulfonyl-6-Piperazinyl-7-Azaindoles, showing strong antagonistic activity to 5-HT6 receptor (5-HT6R) was synthesized and characterized. The series was optimized to reduce activity on D2 receptor. Based on the selectivity against this of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0e7ddf2aebc8b11e2dc823531d7081
https://doi.org/10.1016/j.bmcl.2016.04.024
https://doi.org/10.1016/j.bmcl.2016.04.024
Autor:
K. Banaszak, M. Gaik, M. Maciuszek, A. Gondela, A. Stachowicz, A. Bialas, A. Kitlinska, K. Kwiecinska, H.M. Eggenweiler, M. Bien, L. Wloszczak, Mateusz Michał Tomczyk, P. Guzik, Magdalena Sieprawska-Lupa, Piotr Kowalczyk, M. Jurzak, Marta Sowinska, M. Les, Mateusz Nowak, Aleksandra Sabiniarz, S. Ziemianska, B. Bugaj, Maciej Mikulski, Nicolas Boutard, L. Dudek, Anna Cierpich, A. Biela, R. Lindemann, Adrian Zarebski, H. Pawlik, J. Fogt, E. Cieluch, Joanna Szeremeta-Spisak, Krzysztof Brzózka, T. Rzymski, M. Kujawa, K. Jakubiec, C.H. Fabritius, Katarzyna Wiklik, A. Obara, Anna Buda, P. Niedziejko
Publikováno v:
ChemMedChem. 14(1)
Energy and biomass production in cancer cells are largely supported by aerobic glycolysis in what is called the Warburg effect. The process is regulated by key enzymes, among which phosphofructokinase PFK-2 plays a significant role by producing fruct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4e2e375f345b45513bf24c44f0ee4c
https://pubmed.ncbi.nlm.nih.gov/30378281
https://pubmed.ncbi.nlm.nih.gov/30378281
Autor:
Karolina Gluza, Marcin Leś, Katarzyna Banaszak, Faustyna Gajdosz, Sylwia Sudoł, Lukasz Piotr Dudek, Krzysztof Brzózka, Magdalena Sieprawska-Lupa, Aleksandra Poczkaj, Luigi Stasi, Agnieszka Adamus, Michal Combik, Karolina Wiatrowska, Kinga Michalik, Federico Malusa, Magdalena Mroczkowska, Monika Dobrzańska, Katarzyna Wójcik-Jaszczyńska, Katarzyna Wiklik, Stefan Chmielewski, Grzegorz Witold Topolnicki, Izabela Dolata, Anna Rajda, Peter Littlewood, Magdalena Zawadzka, Adam Radzimierski, Maciej Kujawa, Agnieszka Gibas, Jolanta Mazurek, Grzegorz Ćwiertnia, Maciej Rogacki, Charles Fabritius, Jose Alvarez
Publikováno v:
Cancer Research. 79:4983-4983
Accumulating evidence highlights an important role of type I interferon response in the immune surveillance mechanisms. IFNβ release by antigen-presenting cells promotes spontaneous anti-tumor CD8+ T cell priming being largely dependent on activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::467ce55719f4e019bb17ca6c4e107a63
https://doi.org/10.1158/1538-7445.am2019-4983
https://doi.org/10.1158/1538-7445.am2019-4983
Autor:
Agnieszka Przybylowicz, Marta Sowinska, Krzysztof Brzózka, Agnieszka Adamus, Pawel Guzik, Marcin Król, Urszula Kulesza, Przemyslaw Golik, Mateusz Nowak, Tomasz Rzymski, Karolina Gluza, Justyna Wujkowska, Nicolas Boutard, Piotr Kowalczyk, Magdalena Sieprawska-Lupa, David J. Schultz, Anna Wrobel, Karolina Pyziak, Agnieszka Sroka-Porada, Magdalena Zastawna, Anna Bartosik, Agnieszka Dreas, Faustyna Iwanska
Publikováno v:
Cancer Research. 78:3516-3516
Over-activation of the serine synthesis pathway, upregulation of SHMT2 has been described in over 20% of solid tumors (e.g. breast, lung, colorectal cancers). Such cancer cells are highly dependent on serine. Serine hydroxymethyltransferase (SHMT) pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05aa50551ec7f3c7089566bb10d42e02
https://doi.org/10.1158/1538-7445.am2018-3516
https://doi.org/10.1158/1538-7445.am2018-3516
Autor:
Nikos C. Kyrpides, Kerrie Barry, William B. Whitman, Alex Copeland, Paul G. Richardson, Eugene Goltsman, Eileen Dalin, Miriam Land, Sam Pitluck, Tijana Glavina del Rio, Iain Anderson, Susan Lucas, Magdalena Sieprawska-Lupa, Alla Lapidus, Loren Hauser, Hope Tice
Publikováno v:
Standards in Genomic Sciences
Methanocorpusculum labreanum is a methanogen belonging to the order Methanomicrobiales within the archaeal kingdom Euryarchaeota. The type strain Z was isolated from surface sediments of Tar Pit Lake in the La Brea Tar Pits in Los Angeles, California
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aebf0b6fe11afd04b1f316068d5d742
https://doi.org/10.4056/sigs.35575
https://doi.org/10.4056/sigs.35575
Autor:
Fredrick J. Bohanon, Magdalena Sieprawska-Lupa, William B. Whitman, Iris Porat, Quincy Teng, Robert H. White
Publikováno v:
Molecular Microbiology. 62:1117-1131
Summary Methanococcus maripaludis is a strictly anaerobic, methane-producing archaeon and facultative autotroph capable of biosynthesizing all the amino acids and vitamins required for growth. In this work, the novel 6-deoxy-5-ketofructose-1-phosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958070127761ab5abe7a21026ffbda82
https://doi.org/10.1111/j.1365-2958.2006.05426.x
https://doi.org/10.1111/j.1365-2958.2006.05426.x
Autor:
Yitai Liu, Karl O. Stetter, David R. Boone, Melissa M. Kendall, William B. Whitman, Magdalena Sieprawska-Lupa
Publikováno v:
International Journal of Systematic and Evolutionary Microbiology. 56:1525-1529
Three strains of CO2-reducing methanogens were isolated from marine sediments. Strain PL-15/HP was isolated from marine sediments of the Lipari Islands, near Sicily and the other two strains, Nankai-2 and Nankai-3T, were isolated from deep marine sed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98eee74150a8968760082c73d6a3465
https://doi.org/10.1099/ijs.0.64216-0
https://doi.org/10.1099/ijs.0.64216-0