Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Magdalena Schacherl"'
Autor:
Timo Flügel, Magdalena Schacherl, Anett Unbehaun, Birgit Schroeer, Marylena Dabrowski, Jörg Bürger, Thorsten Mielke, Thiemo Sprink, Christoph A. Diebolder, Yollete V. Guillén Schlippe, Christian M. T. Spahn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Structural studies of translating ribosomes traditionally rely on in vitro assembly and stalling of ribosomes in defined states. To comprehensively visualize bacterial translation, we reactivated ex vivo-derived E. coli polysomes in the PURE
Externí odkaz:
https://doaj.org/article/a8b8bb6841e3415faf91a35352ba940b
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43863 (2012)
BACKGROUND: Archaemetzincins are metalloproteases occurring in archaea and some mammalia. They are distinct from all the other metzincins by their extended active site consensus sequence HEXXHXXGXXHCX(4)CXMX(17)CXXC featuring four conserved cysteine
Externí odkaz:
https://doaj.org/article/683d029b6c714758a9dab952248a4dc0
Autor:
Sarah Paisdzior, Jörg Bürger, Michal Szczepek, Daniel Hilger, Brian Bauer, Annette G. Beck-Sickinger, T. Hilal, Anja Koch, Nicolas A. Heyder, Christian M. T. Spahn, Magdalena Schacherl, Peter Kühnen, Heike Biebermann, Dennis Kwiatkowski, Andrea Schmidt, Monique Gallandi, David Speck, Peter W. Hildebrand, Thorsten Mielke, Brian K. Kobilka, Gunnar Kleinau, Patrick Scheerer
Publikováno v:
Cell Research
The melanocortin-4 receptor (MC4R), a hypothalamic master regulator of energy homeostasis and appetite, is a class A G-protein-coupled receptor and a prime target for the pharmacological treatment of obesity. Here, we present cryo-electron microscopy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3cac4619722e65c3857cb94f1c7078
https://doi.org/10.1038/s41422-021-00569-8
https://doi.org/10.1038/s41422-021-00569-8
Autor:
Magdalena Schacherl, Susann M Fragel, Anna Montada, Ulrich Baumann, Karin Schnetz, Ralf Heermann
Publikováno v:
Nucleic Acids Research
LeuO is a pleiotropic LysR-type transcriptional regulator (LTTR) and co-regulator of the abundant nucleoid-associated repressor protein H-NS in Gammaproteobacteria. As other LTTRs, LeuO is a tetramer that is formed by dimerization of the N-terminal D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0331ff43b13bfcc09a78912be1388969
http://europepmc.org/articles/PMC6698644
http://europepmc.org/articles/PMC6698644
Autor:
Thorsten Mielke, Magdalena Schacherl, Monique Gallandi, Heike Biebermann, Sarah Paisdzior, Michal Szczepek, Daniel Hilger, Andrea Schmidt, T. Hilal, David Speck, Dennis Kwiatkowski, Christian M. T. Spahn, Anja Koch, Jörg Bürger, Peter W. Hildebrand, Patrick Scheerer, Brian K. Kobilka, Nicolas A. Heyder, Annette G. Beck-Sickinger, Peter Kühnen, Brian Bauer, Gunnar Kleinau
SUMMARYThe melanocortin-4 receptor (MC4R), a hypothalamic master regulator of energy homeostasis and appetite, is a G-protein coupled receptor and a prime target for the treatment of obesity. Here, we present cryo-electron microscopy structures of MC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b48a87ce323a39d664c002fcbe0c86eb
https://doi.org/10.1101/2021.04.22.440868
https://doi.org/10.1101/2021.04.22.440868
Autor:
Emily J. Rundlet, Mikael Holm, Magdalena Schacherl, Kundhavai Natchiar, Roger B. Altman, Christian M.T. Spahn, Alexander G. Myasnikov, Scott C. Blanchard
Publikováno v:
Biophysical Journal. 121:32a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d090ab7786ef1877664b858b76585f3
https://doi.org/10.1016/j.bpj.2021.11.2545
https://doi.org/10.1016/j.bpj.2021.11.2545
Autor:
Magdalena Schacherl, Christian Pichlo, Denzel, Thomas Hermanns, Matthias Uthoff, Christine Toelzer, S. Ocal, S. Ruegenberg, K. Chojnacki, Kay Hofmann, Karsten Niefind, Ulrich Baumann
Publikováno v:
Acta Crystallogr F Struct Biol Commun
The identification of initial lead conditions for successful protein crystallization is crucial for structural studies using X-ray crystallography. In order to reduce the number of false-negative conditions, an emerging number of fluorescence-based m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bd7ce3e87f98a0c804f0262e7ff4f3
https://doi.org/10.1107/s2053230x18005253
https://doi.org/10.1107/s2053230x18005253
Autor:
Christian, Pichlo, Linda, Juetten, Fabian, Wojtalla, Magdalena, Schacherl, Dolores, Diaz, Ulrich, Baumann
Publikováno v:
J Biol Chem
Pro-Pro endopeptidase-1 (PPEP-1) is a secreted metalloprotease from the bacterial pathogen Clostridium difficile that cleaves two endogenous adhesion proteins. PPEP-1 is therefore important for bacterial motility and hence for efficient gut colonizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae8d9a346a96713ff523eb82b403a311
https://pubmed.ncbi.nlm.nih.gov/31182482
https://pubmed.ncbi.nlm.nih.gov/31182482
Autor:
Susanne de Boor, Antje Extra, Lukas Scislowski, Magdalena Schacherl, Linda Baldus, Michael Lammers, Ulrich Baumann, Nora Kuhlmann, Ines Neundorf, Philipp Knyphausen
Publikováno v:
Journal of Biological Chemistry. 291:14677-14694
Sirtuins are NAD(+)-dependent lysine deacylases, regulating a variety of cellular processes. The nuclear Sirt1, the cytosolic Sirt2, and the mitochondrial Sirt3 are robust deacetylases, whereas the other sirtuins have preferences for longer acyl chai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea1157c3ec1ea01fd676d5465dfa034
https://doi.org/10.1074/jbc.m116.726307
https://doi.org/10.1074/jbc.m116.726307
Autor:
Nora Kuhlmann, Gerrit J. K. Praefcke, Ulrich Baumann, Magdalena Schacherl, Jason W. Chin, Michael Lammers, Sarah Wroblowski, Leo C. James, Philipp Knyphausen, Hendrik Nolte, Anke Y. Zienert, Susanne de Boor, Marcus Krüger, Katrin Meyer-Teschendorf, Julian Brenig
Publikováno v:
Journal of Biological Chemistry. 291:5484-5499
Rho proteins are small GTP/GDP-binding proteins primarily involved in cytoskeleton regulation. Their GTP/GDP cycle is often tightly connected to a membrane/cytosol cycle regulated by the Rho guanine nucleotide dissociation inhibitor α (RhoGDIα). Rh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906d10a29c7f4fb41be41ff4ab3cab3b
https://doi.org/10.1074/jbc.m115.707091
https://doi.org/10.1074/jbc.m115.707091