Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Magdalena S. Mroz"'
The bile acids, deoxycholic acid and ursodeoxycholic acid, regulate colonic epithelial wound healing
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 314:G378-G387
The intestinal epithelium constitutes an innate barrier which, upon injury, undergoes self-repair processes known as restitution. Although bile acids are known as important regulators of epithelial function in health and disease, their effects on wou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23e40723c22033769a80fdb5c4b32dd
https://doi.org/10.1152/ajpgi.00435.2016
https://doi.org/10.1152/ajpgi.00435.2016
Autor:
Magdalena S. Mroz (7951376)
Background: The epidermal growth factor receptor (EGFR) plays a critical role in regulating transport processes in the intestine. Since EGFR signalling can become dysregulated in several conditions of intestinal disease, the receptor may contribute t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e47772d8e911f020c5d04cee759c48e
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf22e6b4f50ede98c77d077fbe540f3e
https://doi.org/10.1096/fasebj.2018.32.1_supplement.873.15
https://doi.org/10.1096/fasebj.2018.32.1_supplement.873.15
Autor:
Rebecca Reilly, Eugene M. Dempsey, Christof Hiebel, Stephen J. Keely, Judith A. Coppinger, Christian Behl, Magdalena S. Mroz, Edward F. McKone, Kieran Wynne
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Deletion of phenylalanine 508 of the cystic fibrosis transmembrane conductance regulator (ΔF508 CFTR) is a major cause of cystic fibrosis (CF), one of the most common inherited childhood diseases. ΔF508 CFTR is a trafficking mutant that is retained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b64faa087ac07d4899e50c86542e66
https://doi.org/10.1038/s41598-017-06588-z
https://doi.org/10.1038/s41598-017-06588-z
Autor:
Siobhan M. Hendrick, Brian J. Harvey, Catherine M. Greene, Stephen J. Keely, Magdalena S. Mroz
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 307:L407-L418
Bile acids resulting from the aspiration of gastroesophageal refluxate are often present in the lower airways of people with cystic fibrosis and other respiratory distress diseases. Surprisingly, there is little or no information on the modulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1379ee719c650e667715d0210808184e
https://doi.org/10.1152/ajplung.00352.2013
https://doi.org/10.1152/ajplung.00352.2013
Publikováno v:
Neurogastroenterology & Motility. 25:708-711
Bile acids (BA) are becoming increasingly appreciated as enteric hormones that regulate many aspects of intestinal physiology. The BA receptor, TGR5, has been recently shown to be expressed on enteric nerves and enterochromaffin cells (ECs), where it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753c4216e2ee41c1ca6697540784e194
https://doi.org/10.1111/nmo.12148
https://doi.org/10.1111/nmo.12148
Autor:
Michael Scharl, Orlaith B. Kelly, Magdalena S. Mroz, Stephen J. Keely, Padraic G. Fallon, Alan F. Hofmann, Carolina Colliva, Frank E. Murray, Aldo Roda, John F. Gilmer, Roberto Pellicciari, Joseph B. J. Ward
Publikováno v:
The Journal of Physiology. 591:2307-2318
Dihydroxy bile acids, such as chenodeoxycholic acid (CDCA), are well known to promote colonic fluid and electrolyte secretion, thereby causing diarrhoea associated with bile acid malabsorption. However, CDCA is rapidly metabolised by colonic bacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c755c95e57fd792676c9c796a020e24
https://doi.org/10.1113/jphysiol.2013.252544
https://doi.org/10.1113/jphysiol.2013.252544
Autor:
Magdalena S. Mroz, Stephen J. Keely
Publikováno v:
The Journal of Physiology. 590:1907-1920
Dysregulated epithelial fluid and electrolyte transport is a common feature of many intestinal disorders. However, molecular mechanisms that regulate epithelial transport processes are still poorly understood, thereby limiting development of new ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9a419be1f678e85c786385f5936d113
https://doi.org/10.1113/jphysiol.2011.226126
https://doi.org/10.1113/jphysiol.2011.226126
Autor:
Christine Marsh, Alan F. Hofmann, Michael Scharl, Stephen J. Keely, Gail Ferguson, Niamh Keating, Magdalena S. Mroz
Publikováno v:
Journal of Cellular and Molecular Medicine
In patients with bile acid malabsorption, high concentrations of bile acids enter the colon and stimulate Cl(-) and fluid secretion, thereby causing diarrhoea. However, deoxycholic acid (DCA), the predominant colonic bile acid, is normally present at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd87b2ef5bc89460fba5c77170dd94a
https://doi.org/10.1111/j.1582-4934.2009.00838.x
https://doi.org/10.1111/j.1582-4934.2009.00838.x
Autor:
Orlaith B. Kelly, Magdalena S. Mroz, Joseph B. J. Ward, Michael Scharl, Roberto Pellicciari, John F. Gilmer, Padraic G. Fallon, Alan F. Hofmann, Frank E. Murray, Stephen J. Keely, COLLIVA, CAROLINA, RODA, ALDO
Dihydroxy bile acids, such as chenodeoxycholic acid (CDCA), are well known to promote colonic fluid and electrolyte secretion, thereby causing diarrhoea associated with bile acid malabsorption. However, CDCA is rapidly metabolised by colonic bacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e0ecae3d4307aadb47b5e546477b52e7
https://europepmc.org/articles/PMC3650696/
https://europepmc.org/articles/PMC3650696/