Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Magdalena Rowińska-Żyrek"'
Autor:
Justyna Kamińska, Aleksandra Hecel, Joanna Słowik, Agnieszka Rombel-Bryzek, Magdalena Rowińska-Żyrek, Danuta Witkowska
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The most common skin diseases include eczema, psoriasis, acne, and fungal infections. There is often no effective cure for them. Increasing antimicrobial drug resistance prompts us to search for new, safe, and effective therapeutics. Among such inter
Externí odkaz:
https://doaj.org/article/5c234ae20a6f4036a24d14f6d2f0e92c
Autor:
Maria D’Accolti, Denise Bellotti, Emilia Dzień, Carlotta Leonetti, Silvia Leveraro, Valentina Albanese, Erika Marzola, Remo Guerrini, Elisabetta Caselli, Magdalena Rowińska-Żyrek, Maurizio Remelli
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The main limitation to the use of antimicrobial peptides (AMPs) as regular drugs, against antibiotic and antifungal resistance, mainly relates to their rapid degradation by proteolytic enzymes. The introduction of suitable structural changes
Externí odkaz:
https://doaj.org/article/f55082abd99f44b7800720b35b0b10ad
Zn(II) binding to pramlintide results in a structural kink, fibril formation and antifungal activity
Autor:
Dorota Dudek, Emilia Dzień, Joanna Wątły, Agnieszka Matera-Witkiewicz, Aleksandra Mikołajczyk, Agata Hajda, Joanna Olesiak-Bańska, Magdalena Rowińska-Żyrek
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract The antimicrobial properties of amylin, a 37-amino acid peptide hormone, co-secreted with insulin from the pancreas, are far less known than its antidiabetic function. We provide insight into the bioinorganic chemistry of amylin analogues, s
Externí odkaz:
https://doaj.org/article/fe1dba4466b14709ab3c0b63075bc8bd
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Membrane environment often has an important effect on the structure, and therefore also on the coordination mode of biologically relevant metal ions. This is also true in the case of Cu(II) coordination to amylin analogues—rat amylin, amyl
Externí odkaz:
https://doaj.org/article/3e1d9268f0354a6fbf4b7085afb9a695
Autor:
Kinga Garstka, Valentyn Dzyhovskyi, Joanna Wątły, Kamila Stokowa-Sołtys, Jolanta Świątek-Kozłowska, Henryk Kozłowski, Miquel Barceló-Oliver, Denise Bellotti, Magdalena Rowińska-Żyrek
Publikováno v:
Molecules, Vol 28, Iss 10, p 3985 (2023)
Histidine and cysteine residues, with their imidazole and thiol moieties that deprotonate at approximately physiological pH values, are primary binding sites for Zn(II), Ni(II) and Fe(II) ions and are thus ubiquitous both in peptidic metallophores an
Externí odkaz:
https://doaj.org/article/b7d98239cd374c9898f28654db3629d5
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 121 (2022)
Zrt2 is a zinc transporter of the ZIP family. It is predicted to be located in the plasma membrane and it is essential for Candida albicans zinc uptake and growth at acidic pH. Zrt2 from C. albicans is composed of 370 amino acids and contains eight p
Externí odkaz:
https://doaj.org/article/b76ee3d1a4d342b19615b736c1edf6f4
Autor:
Aleksandra Hecel, Małgorzata Ostrowska, Kamila Stokowa-Sołtys, Joanna Wątły, Dorota Dudek, Adriana Miller, Sławomir Potocki, Agnieszka Matera-Witkiewicz, Alicia Dominguez-Martin, Henryk Kozłowski, Magdalena Rowińska-Żyrek
Publikováno v:
Pharmaceuticals, Vol 13, Iss 9, p 228 (2020)
Zn(II) is an inhibitor of SARS-CoV-2′s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores–this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquin
Externí odkaz:
https://doaj.org/article/9bf128aa1d5842bfb46cd1befcd105db
Akademický článek
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Autor:
Joanna Wa̧tły, Aleksandra Hecel, Robert Wieczorek, Magdalena Rowińska-Żyrek, Henryk Kozłowski
Publikováno v:
Inorganic Chemistry. 61:14247-14251
It is supposed that the presence of poly-His regions in close proximity to poly-Gly domains in snake venoms is related to their biological activity; poly-His/poly-Gly (pHpG) peptides inhibit the activity of metalloproteinases during venom storage via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ff572d131124796f0a94ba9e04eaaf
https://doi.org/10.1021/acs.inorgchem.2c02584
https://doi.org/10.1021/acs.inorgchem.2c02584
Publikováno v:
Metallomics. 14(7):1-10
Aspergillus fumigatus, one of the most widespread opportunistic human fungal pathogens, adapts to zinc limitation by secreting a 310 amino acid Aspf2 zincophore, able to specifically bind Zn(II) and deliver it to a transmembrane zinc transporter, Zrf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896f24d2532da5ba951293a0300d2b1a
https://academic.oup.com/metallomics/article/14/7/mfac042/6608364
https://academic.oup.com/metallomics/article/14/7/mfac042/6608364