Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Magdalena R. Mejillano"'
Publikováno v:
Biochemistry. 39:10269-10274
We have determined the binding affinity for binding of the four purine nucleoside triphosphates GTP, ITP, XTP, and ATP to E-site nucleotide- and nucleoside diphosphate kinase-depleted tubulin. The relative binding affinities are 3000 for GTP, 10 for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172ba9c98055967130f6c188eb0bcda3
https://doi.org/10.1021/bi000966n
https://doi.org/10.1021/bi000966n
Autor:
Zacharia S. Cheruvallath, Gunda I. Georg, Magdalena R. Mejillano, Richard H. Himes, Charles T. Burke
Publikováno v:
ChemInform. 24
Taxol (1) is a highly potent antitumor agent, exerting its mechanism of action by promoting the assembly of stable microtubules in cells. We are reporting on the first synthesis and biological evaluation of taxol derivatives with substituted phenyl r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95a1239361afea7567068cdb2f352b5f
https://doi.org/10.1002/chin.199322249
https://doi.org/10.1002/chin.199322249
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1751-1754
The semisynthesis of the four novel taxol analogues baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-tolyl)isoserinate) ( 2 ), baccatin III 13-(N-(p-toluoyl)-(2′R,3′S)-3′-phenylisoserinate) ( 3 ), baccatin III 13-(N-benzoyl-(2′R,3′S)-3′(p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80333ac8760c8bcc3d297f7385c87d8d
https://doi.org/10.1016/s0960-894x(00)80469-2
https://doi.org/10.1016/s0960-894x(00)80469-2
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:735-738
An efficient semi-synthetic approach utilizing the appropriately functionalized (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone ( 4 ) and 7-(p-azidobenzoyl)baccatin III ( 3 ) is described which leads to the targeted biologically active taxol photoaffinity l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3de58f3b5b3c18c89e5ad8b67a5612ac
https://doi.org/10.1016/s0960-894x(00)80402-3
https://doi.org/10.1016/s0960-894x(00)80402-3
Publikováno v:
Biochemistry. 31:3478-3483
In a recent study, we demonstrated that the conversion of carboxyl residues in the C-termini of tubulin to neutral amides with glycine ethyl ester enhanced the ability of the protein to assemble into microtubules and decreased its interaction with mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406fceefb31321ca87257c9bb58ed2bf
https://doi.org/10.1021/bi00128a023
https://doi.org/10.1021/bi00128a023
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:295-298
Two novel taxol analogues, baccatin III 13-(N-(p-chlorobenzoyl)-(2′R,3′S)-phenylisoserinate) ( 2 ) and baccatin III 13-(N-benzoyl-(2′R,3′S)-3′(p-chlorophenyl)isoserinate) ( 3 ) were synthesized from 7-triethylsilyl baccatin III ( 4 ) and N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1093f118aaaf69513fccd483246a1aa
https://doi.org/10.1016/s0960-894x(01)80203-1
https://doi.org/10.1016/s0960-894x(01)80203-1
Publikováno v:
Archives of Biochemistry and Biophysics. 291:356-362
Binding of GTP and GDP to tubulin in the presence or absence of Mg2+ was measured following depletion of the exchangeable site--(E-site) nucleotide. The E-site nucleotide was displaced with a large molar excess of the nonhydrolyzable GTP analogue, GM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc31586f73de2b715aa99fa793490df
https://doi.org/10.1016/0003-9861(91)90146-a
https://doi.org/10.1016/0003-9861(91)90146-a
Autor:
Magdalena R. Mejillano, Zacharia S. Cheruvallath, Charles T. Burke, Gunda I. Georg, Richard H. Himes
Publikováno v:
Journal of medicinal chemistry. 35(22)
Taxol (1) is a highly potent antitumor agent, exerting its mechanism of action by promoting the assembly of stable microtubules in cells. We are reporting on the first synthesis and biological evaluation of taxol derivatives with substituted phenyl r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9163a203971832b158fbc2e7338301
https://pubmed.ncbi.nlm.nih.gov/1359143
https://pubmed.ncbi.nlm.nih.gov/1359143
Autor:
Jyoti P. Nath, Richard H. Himes, Abraham E. Mathew, Valentino J. Stella, Magdalena R. Mejillano
Publikováno v:
Journal of medicinal chemistry. 35(1)
The synthesis and evaluation of some 2'- and 7-amino acid derivatives of taxol (1) are reported. Reaction of taxol with N-protected amino acids gave 2'-N-protected amino acid esters of taxol. However, deprotection of the amino group and subsequent is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26abcc97dea1909aa265ebe9627f5e1
https://pubmed.ncbi.nlm.nih.gov/1346275
https://pubmed.ncbi.nlm.nih.gov/1346275
Publikováno v:
Biochemistry. 29(5)
The question of whether nonhydrolyzable nucleotide analogues and other nucleoside triphosphates support tubulin assembly was addressed. Tubulin which contained residual GTP at the exchangeable site polymerized in the absence of added GTP in the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fafdc44e1533f4c5b697ab8d3c19887
https://pubmed.ncbi.nlm.nih.gov/2108723
https://pubmed.ncbi.nlm.nih.gov/2108723