Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Magdalena Obieziurska-Fabisiak"'
1
Akademický článek
New insights in the mechanism of the SARS-CoV-2 Mpro inhibition by benzisoselenazolones and diselenides
Autor: Luca Sancineto, Francesca Mangiavacchi, Agnieszka Dabrowska, Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Cecilia Scimmi, Veronica Ceccucci, Juan Kong, Yao Zhao, Gianluca Ciancaleoni, Vanessa Nascimento, Bruno Rizzuti, Marco Bortoli, Laura Orian, Anna Kula-Pacurar, Haitao Yang, Jacek Ścianowski, Ying Lei, Krzysztof Pyrc, Claudio Santi
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Although global vaccination campaigns alleviated the SARS-CoV-2 pandemic in terms of morbidity and mortality, the ability of the virus to originate mutants may reduce the efficacy of vaccines, posing a serious risk of a renewed pandemic. The
Externí odkaz: https://doaj.org/article/226d7ea937b54aa098a61f09b34778cd
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2
Akademický článek
Synthesis of a New Class of β-Carbonyl Selenides Functionalized with Ester Groups with Antioxidant and Anticancer Properties—Part II
Autor: Anna Laskowska, Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Aneta Jastrzębska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Ścianowski
Publikováno v: Molecules, Vol 29, Iss 12, p 2866 (2024)
A series of phenyl β-carbonyl selenides with o-ester functionality substituted on the oxygen atom with chiral and achiral alkyl groups was synthesized. All compounds are the first examples of this type of organoselenium derivatives with an ester sub
Externí odkaz: https://doaj.org/article/5218e63f94214e17bdf16bc3d92229a9
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3
Akademický článek
Synthesis of New Chiral β-Carbonyl Selenides with Antioxidant and Anticancer Activity Evaluation—Part I
Autor: Anna Laskowska, Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Aneta Jastrzębska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Ścianowski
Publikováno v: Materials, Vol 17, Iss 4, p 899 (2024)
A series of unsymmetrical phenyl β-carbonyl selenides with o-amido function substituted on the nitrogen atom with chiral alkyl groups was obtained. The compounds form a series of enantiomeric and diastereomeric pairs and present the first examples o
Externí odkaz: https://doaj.org/article/495b6bdf8960448a9f6e2bd25885726c
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4
Akademický článek
The Influence of Long Carbon Chains on the Antioxidant and Anticancer Properties of N-Substituted Benzisoselenazolones and Corresponding Diselenides
Autor: Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Aneta Jastrzębska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Ścianowski
Publikováno v: Pharmaceuticals, Vol 16, Iss 11, p 1560 (2023)
Organoselenium compounds are well-known for their numerous biocapacities, which result from the uniqueness of the selenium atom and the possibility of constructing heterorganic molecules that can mimic the activity of selenoenzymes, crucial for a mul
Externí odkaz: https://doaj.org/article/d91228dcfd3a4535a238ddd8c50d02c0
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5
Akademický článek
Selected N-Terpenyl Organoselenium Compounds Possess Antimycotic Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
Autor: Xiuyi Liang, Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Richa Vartak, Ganming Mao, Ketankumar Patel, Natalya U. Fedosova, Jacek Ścianowski, Blase Billack
Publikováno v: Molecules, Vol 28, Iss 21, p 7377 (2023)
In the present work, a series of N-terpenyl organoselenium compounds (CHB1-6) were evaluated for antimycotic activity by determining the minimum inhibitory concentration (MIC) for each compound in fluconazole (FLU)-sensitive (S1) and FLU-resistant (S
Externí odkaz: https://doaj.org/article/e385197d90344e9a947b7182c2dbc7ca
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6
Akademický článek
Phenylselanyl Group Incorporation for 'Glutathione Peroxidase-Like' Activity Modulation
Autor: Magdalena Obieziurska-Fabisiak, Agata J. Pacuła, Lucia Capoccia, Joanna Drogosz-Stachowicz, Anna Janecka, Claudio Santi, Jacek Ścianowski
Publikováno v: Molecules, Vol 25, Iss 15, p 3354 (2020)
The ability of organoselenium molecules to mimic the activity of the antioxidant selenoenzyme glutathione peroxidase (GPx) allows for their use as antioxidant or prooxidant modulators in several diseases associated with the disruption of the cell red
Externí odkaz: https://doaj.org/article/05cae97af5d44f30b8894ada185d1186
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