Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Magdalena M Bajer"'
Autor:
Tobias Schmid, Johanna S Blees, Magdalena M Bajer, Janine Wild, Luca Pescatori, Giuliana Cuzzucoli Crucitti, Luigi Scipione, Roberta Costi, Curtis J Henrich, Bernhard Brüne, Nancy H Colburn, Roberto Di Santo
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151643 (2016)
The translation inhibitor and tumor suppressor Pdcd4 was reported to be lost in various tumors and put forward as prognostic marker in tumorigenesis. Decreased Pdcd4 protein stability due to PI3K-mTOR-p70S6K1 dependent phosphorylation of Pdcd4 follow
Externí odkaz:
https://doaj.org/article/7fbc4022cf6f408badd4a5fa6926f23f
Autor:
Daniela Rübsamen, Michael M Kunze, Victoria Buderus, Thilo F Brauß, Magdalena M Bajer, Bernhard Brüne, Tobias Schmid
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85314 (2014)
Rapid alterations in protein expression are commonly regulated by adjusting translation. In addition to cap-dependent translation, which is e.g. induced by pro-proliferative signaling via the mammalian target of rapamycin (mTOR)-kinase, alternative m
Externí odkaz:
https://doaj.org/article/0cd0cd9ca988417fa0cb27cf203a7209
Autor:
Johanna S Blees, Heidi R Bokesch, Daniela Rübsamen, Kathrin Schulz, Larissa Milke, Magdalena M Bajer, Kirk R Gustafson, Curtis J Henrich, James B McMahon, Nancy H Colburn, Tobias Schmid, Bernhard Brüne
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46567 (2012)
Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70(S
Externí odkaz:
https://doaj.org/article/d43e632908c94f309f8b3b80f01371d2
Autor:
Zigang Dong, Tobias Schmid, Nancy H. Colburn, James B. McMahon, Kirk R. Gustafson, Michael M. Kunze, Magdalena M. Bajer, Heidi R. Bokesch, Bernhard Brüne, Thilo F. Brauß, Ricardo M. Biondi, H. S. Chen, Johanna S. Blees, Curtis J. Henrich
Publikováno v:
Biochemical Pharmacology. 88:313-321
Deregulation of the phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR)-70kDa ribosomal protein S6 kinase 1 (p70(S6K)) pathway is commonly observed in many tumors. This pathway controls proliferation, survival, and translati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598606d981860f1eb7f0dd3095e65a61
https://doi.org/10.1016/j.bcp.2014.01.034
https://doi.org/10.1016/j.bcp.2014.01.034
Autor:
Janine Wild, Tobias Schmid, Magdalena M. Bajer, Johanna S. Blees, Giuliana Cuzzucoli Crucitti, Roberto Di Santo, Nancy H. Colburn, Roberta Costi, Bernhard Brüne, Luca Pescatori, Luigi Scipione, Curtis J. Henrich
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151643 (2016)
PLoS ONE
PLoS ONE
The translation inhibitor and tumor suppressor Pdcd4 was reported to be lost in various tumors and put forward as prognostic marker in tumorigenesis. Decreased Pdcd4 protein stability due to PI3K-mTOR-p70S6K1 dependent phosphorylation of Pdcd4 follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462f61d9bff317d75e8b7cd155d17d74
http://europepmc.org/articles/PMC4794182?pdf=render
http://europepmc.org/articles/PMC4794182?pdf=render
Autor:
Andreas Weigert, Alyson R. Baker, Daniela Rübsamen, Nancy H. Colburn, Bernhard Brüne, Kathrin Schulz, Larissa Milke, Tobias Schmid, Magdalena M. Bajer, Johanna S. Blees, Lisa K. Eifler
Publikováno v:
Carcinogenesis. 32:1427-1433
The tumor suppressor programmed cell death 4 (Pdcd4) is lost in various tumor tissues. Loss of Pdcd4 has been associated with increased tumorigenic potential and tumor progression. While various mechanisms of Pdcd4 regulation have been described, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d86f47d52646ce10636c6d82d1a29e5
https://doi.org/10.1093/carcin/bgr131
https://doi.org/10.1093/carcin/bgr131
Autor:
Magdalena M. Bajer, Johanna S. Blees, Bernhard Brüne, Kirk R. Gustafson, James B. McMahon, Kathrin Schulz, Curtis J. Henrich, Larissa Milke, Daniela Rübsamen, Heidi R. Bokesch, Nancy H. Colburn, Tobias Schmid
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e46567 (2012)
PLoS ONE, Vol 7, Iss 10, p e46567 (2012)
Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70(S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e0869707df74b6dfa70e259a4b9c82
https://doi.org/10.1371/journal.pone.0046567
https://doi.org/10.1371/journal.pone.0046567
Autor:
Magdalena M. Bajer, Johanna S. Blees, Kathrin Schulz, Tobias Schmid, James B. McMahon, Daniela Rübsamen, Larissa Milke, Curtis J. Henrich, Bernhard Brüne, Nancy H. Colburn
Publikováno v:
Cancer Research. 71:A15-A15
Tumor suppressor Pdcd4 was shown to inhibit the helicase activity of eIF4A and consequently to suppress the translation of mRNAs with structured 5′UTRs. As a result, Pdcd4 inhibits transformation, migration, and invasion in vitro and tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a81a1edc40b71e4f8d475ea96e40fe70
https://doi.org/10.1158/1538-7445.fbcr11-a15
https://doi.org/10.1158/1538-7445.fbcr11-a15