The Crystal Structure of Bacillus thuringiensis Tpp80Aa1 and Its Interaction with Galactose-Containing Glycolipids

Autor: Hannah L. Best, Lainey J. Williamson, Magdalena Lipka-Lloyd, Helen Waller-Evans, Emyr Lloyd-Evans, Pierre J. Rizkallah, Colin Berry

Publikováno v: Toxins, Vol 14, Iss 12, p 863 (2022)

Tpp80Aa1 from Bacillus thuringiensis is a Toxin_10 family protein (Tpp) with reported action against Culex mosquitoes. Here, we demonstrate an expanded target range, showing Tpp80Aa1 is also active against the larvae of Anopheles gambiae and Aedes ae

Externí odkaz: https://doaj.org/article/464c13bcf6e14c4481bcdbf83c7d7ac0

A 2.8 Å structure of zoliflodacin in a DNA-cleavage complex withStaphylococcus aureusDNA gyrase

Autor: Harry Morgan, Magdalena Lipka-Lloyd, Anna J. Warren, Naomi Hughes, John Holmes, Nicolas P. Burton, Eshwar Mahenthiralingam, Ben D. Bax

Since 2000 some thirteen quinolones/fluoroquinolones have been developed and come to market. The quinolones, one of the most successful classes of antibacterial drugs, stabilize DNA-cleavage complexes with DNA gyrase and topo IV, the two bacterial ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b4dc639b6fc795c5120547731237e51
https://doi.org/10.1101/2022.11.30.518515

ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome

Autor: Alexander T. Baker, Eric A. Wilson, Petra Fromme, Chloe D. Truong, Emily A. Bates, LeeAnn Machiesky, Alicia Teijeira-Crespo, Po-Lin Chiu, Daipayan Sarkar, Meike Heurich, Lynda Coughlan, Dewight Williams, Kasim Waraich, Alan L. Parker, Pierre J. Rizkallah, Scott Umlauf, John Vant, Ryan J. Boyd, Taylor S. Cohen, Magdalena Lipka-Lloyd, Chun Kit Chan, Abhishek Singharoy, Bolni Marius Nagalo, Mitesh J. Borad, Josh Vermaas

Publikováno v: Science Advances

Description
We observe previously unknown interactions between clinically important adenovirus vector capsids, platelet factor 4, and CAR.
Vaccines derived from chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26 (HAdV-D26), and h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3779c5167feb036c1a4ac2866731b384
https://orca.cardiff.ac.uk/id/eprint/145867/1/sciadv.abl8213.pdf

The role of streptavidin and its variants in catalysis by biotinylated secondary amines

Autor: Louis C. Morrill, Katarzyna Świderek, Nicolò Santi, Raquel Castillo, Magdalena Lipka-Lloyd, Alexander R. Nödling, Louis Yp Luk, Vicent Moliner, Yi Jin

Publikováno v: Repositori Universitat Jaume I
Universitat Jaume I
Organic & Biomolecular Chemistry
Nödling, A R, Santi, N, Castillo, R, Lipka-Lloyd, M, Jin, Y, Morrill, L C, Świderek, K, Moliner, V & Luk, L Y P 2021, ' The role of streptavidin and its variants in catalysis by biotinylated secondary amines ', Organic & biomolecular chemistry, vol. 19, no. 47, pp. 10424-10431 . https://doi.org/10.1039/d1ob01947c

Here, we combine the use of host screening, protein crystallography and QM/MM molecular dynamics simulations to investigate how the protein structure affects iminium catalysis by biotinylated secondary amines in a model 1,4 conjugate addition reactio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76ab33f16ee8ab6862ad4600d00010d
https://doi.org/10.1039/D1OB01947C

Crystal Structure and Mechanism of the Staphylococcus cohnii Virginiamycin B Lyase (Vgb)

Autor: Magdalena Lipka, Matthias Bochtler, Renata Filipek

Publikováno v: Biochemistry. 47:4257-4265

The semisynthetic streptogramin antibiotic quinupristin/dalfopristin (trade name Synercid, Aventis Pharma) is a mixture of the A-type streptogramin dalfopristin and the B-type streptogramin quinupristin, a capped hexapeptide macrolactone. Quinupristi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d101257129b33249cdc8f85ba7fd8fa1
https://doi.org/10.1021/bi7015266