Výsledky vyhledávání - "Magdalena Legat"

Heme oxygenase-1 protects tumor cells against photodynamic therapy-mediated cytotoxicity

Autor: Alicja Jozkowicz, Magdalena Legat, Tadeusz Issat, Tomasz Stoklosa, S Nazarewski, Mariusz Adamek, Dominika Nowis, Marek Jakóbisiak, H Waś, Jakub Golab, Ewa Wilczek, Piotr Mrowka, Tomasz Grzela, Jozef Dulak, Justyna Niderla, Marcin Makowski, Eliza Glodkowska, Grzegorz M. Wilczynski, A Wrzosek

Publikováno v: Oncogene. 25:3365-3374

Photodynamic therapy is a promising antitumor treatment modality approved for the management of both early and advanced tumors. The mechanisms of its antitumor action include generation of singlet oxygen and reactive oxygen species that directly dama

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c2f81c31ddebef3190dedf0772a5b8
https://doi.org/10.1038/sj.onc.1209378

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The influence of photodynamic therapy on the immune response

Autor: Tomasz Stoklosa, Marek Jakóbisiak, Tadeusz Issat, Jakub Gołąb, Magdalena Legat, Dominika Nowis

Publikováno v: Photodiagnosis and Photodynamic Therapy. 2:283-298

Photodynamic therapy (PDT) is a clinically approved therapeutic modality used for the management of several types of tumors as well as non-malignant diseases. Most of the effects of this treatment regimen result from direct action of singlet oxygen a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d64a0a210d03fd9d37402f545008f60
https://doi.org/10.1016/s1572-1000(05)00098-0

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The possible role of factor H in colon cancer resistance to complement attack

Autor: Dominika Nowis, Barbara Górnicka, Aleksander Wasiutyński, Ewa Wilczek, Jakub Golab, Dariusz Sladowski, Magdalena Legat, Filip A. Konopacki, Grzegorz M. Wilczynski, Michał Mazurkiewicz, Marta Glab, Robert Rzepko, Adam Gorlewicz

Publikováno v: International journal of cancer. 122(9)

A soluble complement inhibitor factor H (FH) and its splice variant factor H-like protein (FHL) have been recently discovered to play a major role in malignant cell escape from complement-mediated cytotoxicity in lung-, ovarian- and glia-derived neop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7a848991113af904f1111239a975f9
https://pubmed.ncbi.nlm.nih.gov/18183578

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Ciglitazone, an agonist of peroxisome proliferator-activated receptor γ, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin

Autor: Tomasz Stoklosa, Magdalena Legat, Eliza Glodkowska, Marcin Makowski, Dominika Nowis, Jakub Golab, Marek Jakóbisiak, Angelika Szokalska, Sylwia Janowska, Tadeusz Issat, Piotr Mrowka

Publikováno v: Scopus-Elsevier

Thiazolidinediones are ligands of PPAR-gamma, a member of the nuclear receptor family. These drugs have shown promising pre-clinical activity in tumor models but clinical studies failed to confirm their beneficial effect. We have studied the in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b499a0f2fce8d96e90fc43514c46bc
https://doi.org/10.3892/ijo.32.1.249

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Ciglitazone, an agonist of peroxisome proliferator-activated receptor gamma, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin

Autor: Piotr, Mrówka, Eliza, Glodkowska, Dominika, Nowis, Magdalena, Legat, Tadeusz, Issat, Marcin, Makowski, Angelika, Szokalska, Sylwia, Janowska, Tomasz, Stoklosa, Marek, Jakóbisiak, Jakub, Golab

Publikováno v: International journal of oncology. 32(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55a1b1e496f2a53c2250c8cd0f73b3ff
https://pubmed.ncbi.nlm.nih.gov/18097565

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Cyclosporine A and its non-immunosuppressive derivative NIM811 induce apoptosis of malignant melanoma cells in in vitro and in vivo studies

Autor: Bozena Kaminska, Andrzej Mackiewicz, Zuzanna Kurzaj, Iwona A. Ciechomska, Aleksandra Wesołowska, Magdalena Legat, Jakub Golab

Publikováno v: International journal of cancer. 117(1)

Advanced melanoma is a highly malignant tumor with an increasing incidence that has a poor prognosis due to resistance to common therapeutic strategies. We have demonstrated previously that cyclosporine A (CsA) induces apoptosis of rat glioma cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739049db8e9b2dbf81e52b2f05d95212
https://pubmed.ncbi.nlm.nih.gov/15880533

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Potentiated antitumor effects of a combination therapy with a farnesyltransferase inhibitor L-744,832 and butyrate in vitro

Autor: Magdalena Legat, Marek Jakóbisiak, Marcin Makowski, Maciej Kopec, Jakub Golab, Katarzyna Strusinska

Publikováno v: ResearcherID
Europe PubMed Central

Farnesyltransferase inhibitors, butyrate and butyric acid derivatives have previously been reported to exert anti-tumor activity in experimental models in vitro and in vivo and have recently gained acceptance as potential anticancer agents. In our st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b0c929a302141b53bda41da456fbe5
https://doi.org/10.3892/or.11.5.1127

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Direct tumor damage mechanisms of photodynamic therapy

Autor: Jakub Golab, Marcin Makowski, Magdalena Legat, Tomasz Stoklosa, Tadeusz Issat, Dominika Nowis

Publikováno v: Europe PubMed Central
Scopus-Elsevier
ResearcherID

Photodynamic therapy (PDT) is a clinically approved and rapidly developing cancer treatment regimen. It is a minimally invasive two-stage procedure that requires administration of a photosensitizing agent followed by illumination of the tumor with vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93220e741a5f01fd1362a995c5028fc
http://europepmc.org/abstract/med/15990919

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Cerivastatin demonstrates enhanced antitumor activity against human breast cancer cell lines when used in combination with doxorubicin or cisplatin

Autor: Dominika Nowis, Janusz Skierski, Magdalena Legat, Mirosława Koronkiewicz, Marek Jakóbisiak, Katarzyna Kozar, Rafal Kaminski, Maciej Kopec, Jakub Golab

Publikováno v: Europe PubMed Central
Scopus-Elsevier
ResearcherID

Competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase are commonly used in the clinic to treat hypercholesterolemia and have been reported to exert antitumor effects. Cerivastatin is a novel, synthetic and the most pharm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d03df59a1987205a1c1a6e148ff8f7
http://europepmc.org/abstract/med/15067336

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Inhibition of Cyclooxygenase-2 Indirectly Potentiates Antitumor Effects of Photodynamic Therapy in Mice

Autor: Marcin Makowski, Tomasz Grzela, Justyna Niderla, Maciej Łazarczyk, Pawel Mroz, Maciej Kopeć, Magdalena Legat, Katarzyna Strusińska, Katarzyna Koziak, Dominika Nowis, Piotr Mrówka, Maria Wa̧sik, Marek Jakóbisiak, Jakub Goła̧b

Publikováno v: Scopus-Elsevier
Experts@Minnesota
Europe PubMed Central

The aim of the present study was to potentiate the antitumor effectiveness of photodynamic therapy (PDT). A cDNA microarray analysis was used to evaluate the gene expression pattern after Photofrin-mediated PDT to find more effective combination trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1baf0d42f17f1fda6fc17cfaf1032a23
http://www.scopus.com/inward/record.url?eid=2-s2.0-10744222642&partnerID=MN8TOARS

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