Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Magdalena Latosińska"'
Publikováno v:
Viruses, Vol 16, Iss 7, p 1073 (2024)
The RNA viruses SARS-CoV, SARS-CoV-2 and MERS-CoV encode the non-structural Nsp16 (2′-O-methyltransferase) that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to the first ribonucleotide in mRNA. Recently, it has been foun
Externí odkaz:
https://doaj.org/article/191252f6f3984b96887dde3a5182f3b4
Publikováno v:
Molecules, Vol 29, Iss 13, p 3199 (2024)
Serine/threonine protein kinases (CK2, PIM-1, RIO1) are constitutively active, highly conserved, pleiotropic, and multifunctional kinases, which control several signaling pathways and regulate many cellular functions, such as cell activity, survival,
Externí odkaz:
https://doaj.org/article/45c50f8499a94a119a1a6f026842e07a
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 445 (2024)
Cytarabine (Ara-C) is a synthetic isomer of cytidine that differs from cytidine and deoxycytidine only in the sugar. The use of arabinose instead of deoxyribose hinders the formation of phosphodiester linkages between pentoses, preventing the DNA cha
Externí odkaz:
https://doaj.org/article/12d93809c9c345c39558a742bb228470
Publikováno v:
Molecules, Vol 29, Iss 2, p 441 (2024)
Our study was motivated by the urgent need to develop or improve antivirals for effective therapy targeting RNA viruses. We hypothesized that analogues of favipiravir (FVP), an inhibitor of RNA-dependent RNA polymerase (RdRp), could provide more effe
Externí odkaz:
https://doaj.org/article/4907f2386c1e4a95b3b8b0378f8b6662
Autor:
Jolanta Natalia Latosińska, Magdalena Latosińska, Janez Seliger, Veselko Žagar, Tomaž Apih, Paweł Grieb
Publikováno v:
Molecules, Vol 28, Iss 8, p 3308 (2023)
Favipiravir (6-fluoro-3-hydroxypyrazine-2-carboxamide, FPV), an active pharmaceutical component of the drug discovered and registered in March 2014 in Japan under the name Avigan, with an indication for pandemic influenza, has been studied. The study
Externí odkaz:
https://doaj.org/article/6eae6584041a4891a214ba6e06f5c504
Publikováno v:
Molecules, Vol 28, Iss 1, p 147 (2022)
A series of new congeners, 1-[2-(1-adamantyl)ethyl]-1H-benzimidazole (AB) and 1-[2-(1-adamantyl)ethyl]-4,5,6,7-tetrahalogeno-1H-benzimidazole (Hal=Cl, Br, I; tClAB, tBrAB, tIAB), have been synthesized and studied. These novel multi-target ligands com
Externí odkaz:
https://doaj.org/article/6116e938d7e84e378e9660f8d995abfa
Autor:
Veselko Žagar, Magdalena Latosińska, Tomaž Apih, Grzegorz Andrzej Olejniczak, Janez Seliger, A. Gregorovič, Jolanta Natalia Latosińska
Publikováno v:
European Journal of Pharmaceutical Sciences. 85:18-30
The polymorphism of anhydrous caffeine (1,3,7-trimethylxanthine; 1,3,7-trimethyl-1H-purine-2,6-(3H,7H)-dione) has been studied by (1)H-(14)N NMR-NQR (Nuclear Magnetic Resonance-Nuclear Quadrupole Resonance) double resonance and pure (14)N NQR (Nuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e60d964804ab332e27e8692e7bdeb4
https://doi.org/10.1016/j.ejps.2016.01.025
https://doi.org/10.1016/j.ejps.2016.01.025
Publikováno v:
Crystal Growth & Design. 15:5464-5475
The crystal structure of 1,4-di(2-phenyl-1H-imidazol-4-yl)benzene (DPI4B) is determined by X-ray diffraction with a final R-factor of 6.42% at room temperature. It crystallizes with a space group P21/c, Z = 4, a = 5.01790(10), b = 28.8971(6), and c =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::994e3ead8646f026abdf39aee7fb302c
https://doi.org/10.1021/acs.cgd.5b01104
https://doi.org/10.1021/acs.cgd.5b01104
Autor:
Magdalena Latosińska, Jolanta Natalia Latosińska, Marek Szafrański, Veselko Žagar, Dorota V. Burchardt, Janez Seliger
Publikováno v:
European Journal of Pharmaceutical Sciences. 77:141-153
Three experimental techniques 1H–14N NQDR, 13C CP/MAS NMR and X-ray and Density Functional Theory (GGA/BLYP with PBC) and Hirshfeld surfaces were applied for the structure–activity oriented studies of two phyto-antioxidants and anticarcinogens: i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c649b4732d1d8c134bee0cacef7cb41e
https://doi.org/10.1016/j.ejps.2015.06.003
https://doi.org/10.1016/j.ejps.2015.06.003
Publikováno v:
Aerospace Science and Technology. 43:301-313
UV radiation is an important problem in climatology, ecology but also has direct effect on human health. A novel method for analysis and prediction of global erythemal UV for clear-sky at noon at any localisation, expressed as the UV index, has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ac457372f8216cfc8ad73c81b9124ae
https://doi.org/10.1016/j.ast.2015.03.011
https://doi.org/10.1016/j.ast.2015.03.011